scholarly journals Hemodynamic and Hematologic Profile of Healthy Adults Ingesting Dietary Supplements Containing 1,3-Dimethylamylamine and Caffeine

2011 ◽  
Vol 5 ◽  
pp. NMI.S8568 ◽  
Author(s):  
Tyler M. Farney ◽  
Cameron G. McCarthy ◽  
Robert E. Canale ◽  
Rick J. Allman ◽  
Richard J. Bloomer
Keyword(s):  
Blood Glucose ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Fasting Blood Glucose ◽  
Daily Intake ◽  
Rate Pressure Product ◽  
Hemodynamic Effects ◽  
Lipid Panel ◽  
Oxyelite Pro ◽  
Hematologic Profile

Background 1,3-dimethylamylamine (a constituent of geranium), alone and in combination with caffeine, is widely used within dietary supplements. We have recently determined the hemodynamic effects of 1,3-dimethylamylamine and caffeine alone and in combination, using a single ingestion study. However, no study has determined the hemodynamic effects of these ingredients following chronic use. Moreover, no study has determined the effects of these ingredients on bloodborne variables related to health and safety. Therefore, the purpose of this investigation was to assess the hemodynamic and hematologic profile of two different dietary supplements containing 1,3-dimethylamylamine and caffeine (in addition to other ingredients), before and after two weeks of daily intake. Methods 7 men (24.9 ± 4.2 yrs) ingested the dietary supplement Jack3d™, while 4 men and 2 women (22.5 ± 1.8 yrs) ingested the dietary supplement OxyELITE Pro™ once per day for two weeks. On days 1 and 15, resting heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure were measured and rate pressure product (RPP) was calculated. Fasting blood samples were analyzed for complete blood counts, comprehensive metabolic panel, and lipid panel. These tests were done prior to ingestion of supplement. On days 1 and 15 following blood collection, subjects ingested the assigned supplement (2 servings) and HR, SBP, DBP, and RPP were recorded at 30, 60, 90, and 120 minutes post-ingestion. Results After 14 days of treatment, resting HR, SBP, DBP, and RPP were not increased ( P > 0.05). No significant changes were noted in any measured bloodborne variable, with the exception of an increase in fasting blood glucose with ingestion of Jack3d™ ( P = 0.02). In response to acute intake of the supplements, HR, DBP, and RPP were not increased statistically ( P > 0.05). SBP was increased with OxyELITE Pro™ ( P = 0.03), but not with Jack3d™ ( P = 0.09). Compared to pre-ingestion and in general, both supplements resulted in an increase in SBP, DBP, and RPP from 5%-15%, with a peak occurring at the 60 or 90 minute post-ingestion time. Conclusion Acute ingestion of OxyELITE Pro™, but not Jack3d™, results in an increase in SBP. Chronic intake of two servings per day of OxyELITE Pro™ or Jack3d™ over a 14 day period does not result in an elevation in resting HR, SBP, DBP, or RPP. No significant changes are noted in any measured bloodborne variable following 14 days of ingestion, with the exception of blood glucose with Jack3d™. Longer term intervention studies inclusive of larger sample sizes are needed to extend these findings.

scholarly journals The Role of Bioactive Compounds from Dietary Spices in the Management of Metabolic Syndrome: An Overview

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 175
Author(s):  
Dana Hasan Alkhatib ◽  
Abdul Jaleel ◽  
Maryam Naveed Muhammad Tariq ◽  
Jack Feehan ◽  
Vasso Apostolopoulos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Dietary Supplements ◽  
Bioactive Compounds ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Preventive Measure ◽  
Blood Lipid ◽  
Lifestyle Changes

Metabolic syndrome (MetS) is a combination of physiologically dysregulated parameters that can include elevated fasting blood glucose, high blood pressure, central obesity, increased triglyceride levels, insulin resistance, diabetes, elevated low density lipoprotein levels, and reduced high density lipoprotein levels in the blood. Effective clinical management of MetS is critical as it is strongly associated with long lasting and fatal complications in patients. Alongside standard care of lifestyle changes and medication, dietary supplements derived from herbal resources could be an alternative therapeutic strategy that is safe, efficient, culturally acceptable, and has few side effects. Of the dietary supplements, spicy foods have always been considered a great source of functional bioactive compounds. Herbal therapy is broadly used in many countries as a treatment or as a preventive measure in the management of MetS risk factors, including blood glucose, blood pressure, and blood lipid levels. Herein, an attempt is made to evaluate the recent studies in the management of MetS with herbal alternatives, and to explore the possibility of their use as therapeutic treatments or supplements.

scholarly journals A Finished Dietary Supplement Stimulates Lipolysis and Metabolic Rate in Young Men and Women

2011 ◽  
Vol 5 ◽  
pp. NMI.S8567 ◽  
Author(s):  
Cameron G. McCarthy ◽  
Tyler M. Farney ◽  
Robert E. Canale ◽  
Rick J. Alleman ◽  
Richard J. Bloomer
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Metabolic Rate ◽  
Dietary Supplement ◽  
Body Fat ◽  
Rate Pressure Product ◽  
Healthy Human ◽  
Men And Women ◽  
Fat Loss ◽  
Oxyelite Pro

Background Dietary supplements are often marketed to increase lipolysis and thermogenesis, with the proposed end result being weight loss and body fat reduction. It was the purpose of the present investigation to study the acute effects of a weight/fat loss supplement within a sample of healthy human subjects. Methods Twelve subjects (men 24.8 ± 4.3 yrs; women 22.8 ± 0.4 yrs) ingested a dietary supplement (OxyELITE Pro™) or a placebo, on two separate days in a double-blind, cross-over design. Blood samples were collected immediately before ingestion, and at 60 and 120 minutes post ingestion, and analyzed for plasma glycerol and free fatty acids (FFA). Breath samples were collected immediately before ingestion and at 30, 60, 90, and 120 minutes post ingestion, for a measure of kilocalorie expenditure using indirect calorimetry. Area under the curve (AUC) was calculated. Heart rate and blood pressure were recorded at all times and rate pressure product (RPP) was calculated. Results AUC was greater for supplement compared to placebo for glycerol (22.74 ± 1.98 μg · mL-1 · 2 hr-1 vs. 15.76 ± 1.36 μg · mL-1 · 2 hr-1; P = 0.001), FFA(1.62 ± 0.07 mmol · L-1 · 2 hr-1 vs. 0.78 ± 0.12 mmol · L-1 · 2 hr-1; P < 0.0001), and kilocalorie expenditure (149 ± 7 kcal · 2 hr-1 vs. 122 ± 8 kcal · 2 hr-1; P = 0.005). Heart rate ( P = 0.02), systolic blood pressure ( P < 0.0001), and RPP ( P = 0.002) were higher for supplement compared to placebo. Conclusion Ingestion of OxyELITE Pro™ resulted in an increase in blood markers of lipolysis, as well as metabolic rate, during a two-hour post ingestion time period. An increase in hemodynamic variables was also observed. These findings are in reference to a sample of healthy men and women who were naïve to treatment with the dietary supplement. Additional work is needed to determine if the acute changes observed here would persist with chronic use of the supplement and possibly lead to weight/body fat loss over time.

scholarly journals Vitamin Dietary Supplement: Changes and Challenges with the New ANVISA Regulations

2021 ◽  
Author(s):  
Lucile Tiemi Abe-Matsumoto ◽  
Viviane de Paula Acosta Iglesia ◽  
Regina Sorrentino Minazzi-Rodrigues
Keyword(s):  
Vitamin D ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Daily Intake ◽  
Fold Increase ◽  
Health Surveillance ◽  
Food Supplements ◽  
Extensive Discussion ◽  
The Impact ◽  
The Ideal

AbstractIn July 2018, the Brazilian National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária, ANVISA, in Portuguese) published new regulations for food supplements, leading to changes both in the sales denomination and labeling statements, and in the composition of these products. Among dietary supplements, those containing vitamins are the most consumed by the population. The objective of the present work is to discuss the changes in the parameters established for the products containing vitamins, mainly in relation to the required and allowed concentrations of micronutrients, and to verify the impact of these changes for the population since the publication of the new standards. Until July 2018, vitamin-based products containing between 15% and 100% of the recommended daily intake (RDI) of these micronutrients were classified as vitamin supplements; above this dosage, they were considered medicines. The new legislation changed the minimum and maximum limits allowed for vitamin food supplements. Taking into account the maximum vitamin limits established for adults, the most relevant differences were the increase in these limits in a proportion of 100, 76 and 43 times in regarding vitamins E, B6 and C respectively, when compared to those previously established. For the required minimum limits, the major difference was observed for vitamin D, with a four-fold increase in its concentration. In conclusion, changes in legislation can influence the health of the population, so the ideal amounts of vitamin in supplements and the recommendation to consume these products require extensive discussion and reflection.

scholarly journals Heavy Metal contamination of Dietary Supplements products available in the UAE markets and the associated risk

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ammar Abdulrahman Jairoun ◽  
Moyad Shahwan ◽  
Sa’ed H. Zyoud
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Metal Contamination ◽  
Inductively Coupled Plasma ◽  
Heavy Metal Contamination ◽  
Safety Concern ◽  
Daily Intake ◽  
Acceptable Daily Intake

Abstract A specific safety concern is the possibility that a dietary supplement could be contaminated with heavy metals. This research was undertaken to investigate the daily exposure levels of heavy metals in dietary supplements available in the UAE and to explore the factors associated with the contamination of dietary supplements with heavy metals. A total of 277 dietary supplement samples were collected from the UAE market and prepared for the analysis of selected heavy metal contamination. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the presence of heavy metals. The average daily intake of cadmium was 0.73 μg [95% CI 0.61–0.85], compared to the acceptable daily intake (ADI) of 6 μg; the daily intake of lead was 0.85 μg [95% CI 0.62–1.07], compared to the acceptable daily intake (ADI) of 20 μg; and the daily intake of arsenic was 0.67 μg [95% CI 0.57–0.78], compared to the acceptable daily intake of 10 μg. Although the dietary supplements available in the UAE have low levels of heavy metal contamination, numerous individuals are consuming a number of different dietary supplements every day and thereby may experience a cumulative level of toxic exposure. Dietary supplements formulations (Categories), dosage forms and country of origin are strong determents of heavy metal contamination in dietary supplements products.

scholarly journals Hyperandrogenism Does Not Influence Metabolic Parameters in Adolescent Girls with PCOS

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Kim Forrester-Dumont ◽  
Ovidiu Galescu ◽  
Andrey Kolesnikov ◽  
Nouhad Raissouni ◽  
Amrit Bhangoo ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Adolescent Girls ◽  
Fasting Blood Glucose ◽  
Metabolic Parameters ◽  
Control Group ◽  
Total Testosterone ◽  
Test Analysis ◽  
Lipid Panel ◽  
Pcos Group

Background.Underlying insulin resistance and/or obesity has clearly been implicated in the development of metabolic syndrome in adolescents and young adults with polycystic ovarian syndrome (PCOS). It is not clear however what role hyperandrogenism has on the development of metabolic syndrome or its role on those metabolic parameters associated with metabolic syndrome.Methods.We studied 107 adolescent girls; 54 had PCOS according to NIH criteria. Data was obtained for systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI), total testosterone (T), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, fasting lipid profile, and glucose. The PCOS group was divided initially into subgroups according to BMI (kg/m2), then based on T (ng/dL) levels as follows: High Testosterone PCOS (HT), Intermediate Testosterone PCOS (IT), Obese and Normal Testosterone (ONT), and lean and normal T (Control, C).t-test analysis was performed in between all the groups.Results.There was no statistical difference between HT and IT, HT and ONT, or IT and ONT in SBP, DBP, fasting blood glucose, lipid panel, LH, FSH, and prolactin levels. The control group had lower SBP and BMI comparing with ONT, IT, and HT groups. There were no statistical differences found in DBP, fasting blood glucose, lipid panel, LH, FSH, or Prolactin.Conclusion.Metabolic profile in adolescent girls with PCOS is not affected by either the presence of hyperandrogenism or the degree of hyperandrogenism.

scholarly journals Comparison of Serum MOTS-c Levels in Patients with Multiple Sclerosis and Healthy Controls

2021 ◽  
Author(s):  
Selma Tekin ◽  
Levent Sinan Bir ◽  
Esin Avci ◽  
Hande Senol ◽  
Işık Tekin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Glucose ◽  
Protective Factor ◽  
Fasting Blood Glucose ◽  
Multivariate Logistic Regression Analysis ◽  
Therapeutic Options ◽  
Great Promise ◽  
Healthy Controls ◽  
Reading Frame ◽  
Lipid Panel

Abstract Background Multiple sclerosis (MS) is a major global problem as its pathogenesis is understood more clearly, therapeutic options expand accordingly. Mitochondrial open-reading-frame of the twelve S rRNA–c (MOTS-c) is a novel mitochondria-derived protein acting on metabolic homeostasis. Objective The main objectives of this report are giving an idea of the role of serum MOTS-c in the pathophysiology of the disease in MS patients, investigating whether the mechanism of MOTS-c. Methods Forty-three patients diagnosed with relapsing-remitting MS and 41 healthy controls were enrolled in the study. MOTS-c, fasting blood glucose, insulin, HOMA-IR, lipid panel, and body-mass index were assessed. Results The patients’ MOTS-c levels remained significantly lower than the controls, while their fasting blood glucose and HOMA-IR values were higher. Our multivariate logistic regression analysis established that increased MOTS-c levels could be a protective factor from the development of MS disease. The area under the ROC curve for MOTS-c was calculated as 0.782 (95% CI: 0.684–0.879, p = 0.0001). Conclusions Our study is the first to scrutinize MOTS-c levels in MS patients. We tried to provide clinical evidence that MOTS-c could act as a highly discriminative biomarker between MS patients and controls and hold great promise for new therapeutic options.

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

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