scholarly journals Sensitivity-enhanced chemical exchange saturation transfer (CEST) MRI with least squares optimization of Carr Purcell Meiboom Gill multi-echo echo planar imaging

2014 ◽  
Vol 9 (2) ◽  
pp. 177-181 ◽  
Author(s):  
Phillip Zhe Sun ◽  
Yu Wang ◽  
Jie Lu
Keyword(s):  
Least Squares ◽  
Chemical Exchange ◽  
Echo Planar Imaging ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Planar Imaging ◽  
Cest Mri ◽  
Least Squares Optimization ◽  
Echo Planar

scholarly journals Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents

2021 ◽  
Vol 14 (2) ◽  
pp. 79 ◽  
Author(s):  
Martin Kunth ◽  
Christopher Witte ◽  
Leif Schröder
Keyword(s):  
Spin Exchange ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Planar Imaging ◽  
Internal Reference ◽  
Cest Mri ◽  
Exchange Kinetics ◽  
Magnetic Resonance Imaging Mri ◽  
Echo Planar

Xenon magnetic resonance imaging (MRI) provides excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST). To this end, molecular hosts such as cryptophane-A or cucurbit[n]urils provide unique opportunities to design switchable MRI reporters. The concentration determination of such xenon binding sites in samples of unknown dilution remains, however, challenging. Contrary to 1H CEST agents, an internal reference of a certain host (in this case, cryptophane-A) at micromolar concentration is already sufficient to resolve the entire exchange kinetics information, including an unknown host concentration and the xenon spin exchange rate. Fast echo planar imaging (EPI)-based Hyper-CEST MRI in combination with Bloch–McConnell analysis thus allows quantitative insights to compare the performance of different emerging ultra-sensitive MRI reporters.

scholarly journals A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol

2017 ◽  
Vol 79 (3) ◽  
pp. 1553-1558 ◽  
Author(s):  
Yin Wu ◽  
Iris Y. Zhou ◽  
Takahiro Igarashi ◽  
Dario L. Longo ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Mri
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