Simulation, phantom validation, and clinical evaluation of fast pH-weighted molecular imaging using amine chemical exchange saturation transfer echo planar imaging (CEST-EPI) in glioma at 3 T

2016 ◽  
Vol 29 (11) ◽  
pp. 1563-1576 ◽  
Author(s):  
Robert J. Harris ◽  
Timothy F. Cloughesy ◽  
Linda M. Liau ◽  
Phioanh L. Nghiemphu ◽  
Albert Lai ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Clinical Evaluation ◽  
Chemical Exchange ◽  
Echo Planar Imaging ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Planar Imaging ◽  
Echo Planar ◽  
Phantom Validation

scholarly journals Responsive ParaCEST Contrast Agents

Inorganics ◽  
2019 ◽  
Vol 7 (5) ◽  
pp. 68 ◽  
Author(s):  
Éva Tóth ◽  
Célia S. Bonnet
Keyword(s):  
Magnetic Resonance Imaging ◽  
Coordination Chemistry ◽  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
New Type ◽  
Paramagnetic Complexes

This article aimed at reviewing the advances on the development of paramagnetic complexes used as chemical exchange saturation transfer agents in magnetic resonance imaging. This relatively new type of contrast opens new avenues in the development of MRI probes for molecular imaging, and coordination chemistry lies at the center of such advances. Strategies to detect important biomarkers such as pH, cations, anions, metabolites, enzyme, and O2 were described. The current challenges, limitations, and opportunities in this field of research were discussed.

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