scholarly journals Association between Tumor Acidity and Hypervascularity in Human Gliomas Using pH-Weighted Amine Chemical Exchange Saturation Transfer Echo-Planar Imaging and Dynamic Susceptibility Contrast Perfusion MRI at 3T

2019 ◽  
Vol 40 (6) ◽  
pp. 979-986 ◽  
Author(s):  
Y.-L. Wang ◽  
J. Yao ◽  
A. Chakhoyan ◽  
C. Raymond ◽  
N. Salamon ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Dynamic Susceptibility ◽  
Saturation Transfer ◽  
Planar Imaging ◽  
Dynamic Susceptibility Contrast ◽  
Human Gliomas ◽  
Tumor Acidity ◽  
Susceptibility Contrast ◽  
Echo Planar

scholarly journals Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents

2021 ◽  
Vol 14 (2) ◽  
pp. 79 ◽  
Author(s):  
Martin Kunth ◽  
Christopher Witte ◽  
Leif Schröder
Keyword(s):  
Spin Exchange ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Planar Imaging ◽  
Internal Reference ◽  
Cest Mri ◽  
Exchange Kinetics ◽  
Magnetic Resonance Imaging Mri ◽  
Echo Planar

Xenon magnetic resonance imaging (MRI) provides excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST). To this end, molecular hosts such as cryptophane-A or cucurbit[n]urils provide unique opportunities to design switchable MRI reporters. The concentration determination of such xenon binding sites in samples of unknown dilution remains, however, challenging. Contrary to 1H CEST agents, an internal reference of a certain host (in this case, cryptophane-A) at micromolar concentration is already sufficient to resolve the entire exchange kinetics information, including an unknown host concentration and the xenon spin exchange rate. Fast echo planar imaging (EPI)-based Hyper-CEST MRI in combination with Bloch–McConnell analysis thus allows quantitative insights to compare the performance of different emerging ultra-sensitive MRI reporters.

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