Discovery of Natural Product‐Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3‐Phenylisoxazolines as Antifungal Agents

2020 ◽  
Vol 17 (12) ◽  
Author(s):  
Zhiyan Liu ◽  
Jiangping Cao ◽  
Xiaoting Yan ◽  
Wanqing Cheng ◽  
Xiaoguang Wang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Natural Product ◽  
Antifungal Agents

The diverse bioactivity of α-mangostin and its therapeutic implications

2021 ◽  
Vol 13 (19) ◽  
pp. 1679-1694
Author(s):  
Tejashri Chavan ◽  
Aaron Muth
Keyword(s):  
Biological Activity ◽  
Natural Product ◽  
Secondary Metabolite ◽  
Bacterial Growth ◽  
Biological Effects ◽  
Structural Features ◽  
Therapeutic Implications ◽  
Specific Disease ◽  
Disease States ◽  
Key Pathways

α-Mangostin is a xanthone natural product isolated as a secondary metabolite from the mangosteen tree. It has attracted a great deal of attention due to its wide-ranging effects on certain biological activity, such as apoptosis, tumorigenesis, proliferation, metastasis, inflammation, oxidation, bacterial growth and metabolism. This review focuses on the key pathways directly affected by α-mangostin and how this varies between disease states. Insight is also provided, where investigated, into the key structural features of α-mangostin that produce these biological effects. The review then sheds light on the utility of α-mangostin as a investigational tool for certain diseases and demonstrate how future derivatives may increase selectivity and potency for specific disease states.

scholarly journals Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

2011 ◽  
Vol 7 ◽  
pp. 1475-1485 ◽  
Author(s):  
Charles Dylan Turner ◽  
Marco A Ciufolini
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Fredericamycin A

This is a review of our efforts toward the synthesis of a group of natural products that display noteworthy biological activity: Fredericamycin A, nothapodytine B, and topopyrones B and D. In each case, directed aromatic functionalization methodology greatly facilitated the assembly of the key molecular subunits.

Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a

2014 ◽  
Vol 18 (03) ◽  
pp. 188-199 ◽  
Author(s):  
Áron Roxin ◽  
Thomas D. MacDonald ◽  
Gang Zheng
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Photodynamic Therapy ◽  
Natural Product ◽  
Synthesis And Characterization ◽  
Facile Synthesis ◽  
H Nmr ◽  
F Ring ◽  
C Nmr

Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is an analog of previously described natural exocyclic F-ring-containing porphyrins (1–4) and chlorins (5–10). The structure of 12 was confirmed using a combination of 1D 1 H NMR, 2D COSY 1 H NMR, Jmod 13 C NMR and HRMS analysis. The biological activity of 12 was explored, and we found that this compound does not possess strong antioxidant activity like its natural product counterparts, but is a capable photosensitizer for photodynamic therapy.

scholarly journals Recovery of pure C-phycoerythrin from a limestone drought tolerant cyanobacterium Nostoc sp. and evaluation of its biological activity

2020 ◽  
pp. 115-128
Author(s):  
Bahareh Nowruzi ◽  
Hossein Fahimi ◽  
Adriana Sturion Lorenzi
Keyword(s):  
Biological Activity ◽  
Antifungal Agents ◽  
Extreme Environments ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Biotechnological Applications ◽  
Drought Tolerant ◽  
Drought Conditions ◽  
Antibacterial And Antifungal ◽  
First Time

Se realizó la caracterización de ficoeritrina de la cepa A5 de Nostoc sp., seguida de investigación de su actividad biológica para aplicaciones biotecnológicas. Para la extracción de ficoeritrina, el uso de tampón acetato (pH 5.1) produjo 65.04 µg mL-1, y se identificó como C-ficoeritrina. Los resultados de su actividad antioxidante sugirieron su acción como un potente eliminador de radicales libres. Además, la C-ficoeritrina de Nostoc mostró una capacidad notable como agente antibacteriano y antifúngico, con estabilidad significativa de hasta 10 días. La glucosa (4 mg mL-1) fue un buen conservante para la C-ficoeritrina a 25 y 4 ºC. Se obtuvo por primera vez una C-ficoeritrina estable de Nostoc sp. en condiciones de sequía en piedra caliza, lo que demuestra la necesidad de estudiar microorganismos de ambientes extremos. The phycoerythrin characterization from Nostoc sp. strain A5 was done, followed by investigation of its biological activity for biotechnological applications. For phycoerythrin extraction, the use of acetate buffer (pH 5.1) resulted in 65.04 µg mL-1, and C-phycoerythrin was identified. Results of its antioxidant activity suggested action as a potent free radical scavenger. In addition, Nostoc's C-phycoerythrin showed noteworthy ability for antibacterial and antifungal agents with significant stability up to 10 days. Glucose (4 mg mL-1) was a good preservative for C-phycoerythrin at 25 and 4 ºC. A stable C-phycoerythrin from Nostoc sp. was obtained for the first time from limestone drought conditions, showing the need of studying microorganisms from extreme environments.

ChemInform Abstract: Neocryptolepine (Cryprotackieine), a Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity.

ChemInform ◽  
2015 ◽  
Vol 46 (10) ◽  
pp. no-no
Author(s):  
Andrea B. J. Bracca ◽  
Daniel A. Heredia ◽  
Enrique L. Larghi ◽  
Teodoro S. Kaufman
Keyword(s):  
Biological Activity ◽  
Natural Product ◽  
Bioactive Natural Product

STEROIDS PRESENT IN THE FOLLICULAR FLUID OF THE MARE

1960 ◽  
Vol 20 (2) ◽  
pp. 147-156 ◽  
Author(s):  
R. V. SHORT
Keyword(s):  
Biological Activity ◽  
Natural Product ◽  
Follicular Fluid ◽  
Physiological Significance ◽  
Chromatographic Techniques ◽  
First Time

SUMMARY Using paper chromatographic techniques, it has been possible to identify the following steroids in the follicular fluid of the mare (results expressed as μg/1.): oestradiol-17β, 460 μg; oestrone, 34 μg; cortisol, 12 μg; progesterone, 124 μg; 17α-hydroxyprogesterone, 66 μg; epitestosterone, 24 μg; androstenedione, 136 μg. In addition to these seven compounds, 136 μg of an unidentified oestrogen-like substance and 52 μg of an unidentified 17-ketosteroid were also present. This is the first time that epitestosterone has been identified as a natural product, and the possible significance of this compound is discussed. 19-Hydroxyandrostenedione, the postulated intermediate in the formation of oestrone from androstenedione, was not detected in this study, and some doubt is therefore cast on the theory that it is an essential intermediate in the biosynthesis of the ovarian oestrogens. The presence of relatively large amounts of an unidentified polar oestrogen in follicular fluid suggests that it may be of some physiological significance, although at the present time no information is available on the biological activity of this compound.

ChemInform Abstract: New Antifungal Agents: Synthesis and Biological Activity

ChemInform ◽  
2010 ◽  
Vol 24 (46) ◽  
pp. no-no
Author(s):  
V. GIRIJAVALLABHAN ◽  
A. K. GANGULY ◽  
A. K. SAKSENA ◽  
A. B. COOPER ◽  
R. LOVEY ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antifungal Agents

scholarly journals Computed Regioselectivity and Conjectured Biological Activity of Ene Reactions of Singlet Oxygen with the Natural Product Hyperforin

2017 ◽  
Vol 93 (2) ◽  
pp. 626-631 ◽  
Author(s):  
Inna Abramova ◽  
Benjamin Rudshteyn ◽  
Joel F. Liebman ◽  
Alexander Greer
Keyword(s):  
Biological Activity ◽  
Singlet Oxygen ◽  
Natural Product ◽  
Ene Reactions

scholarly journals Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. I. Discovery, isolation and biological activity.

1992 ◽  
Vol 45 (3) ◽  
pp. 306-312 ◽  
Author(s):  
JOSEPH O''SULLIVAN ◽  
DOUGLAS W. PHILLIPSON ◽  
DONALD R. KIRSCH ◽  
SUSAN M. FISHER ◽  
MARGARET H. LAI ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antifungal Agents
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