scholarly journals Computed Regioselectivity and Conjectured Biological Activity of Ene Reactions of Singlet Oxygen with the Natural Product Hyperforin

2017 ◽  
Vol 93 (2) ◽  
pp. 626-631 ◽  
Author(s):  
Inna Abramova ◽  
Benjamin Rudshteyn ◽  
Joel F. Liebman ◽  
Alexander Greer
Keyword(s):  
Biological Activity ◽  
Singlet Oxygen ◽  
Natural Product ◽  
Ene Reactions

Effects of Singlet Oxygen on the Biological Activity of DNA and Its Involvement in Single Strand-Break Formation

1988 ◽  
pp. 473-477
Author(s):  
Heribert Wefers ◽  
Paolo Di Mascio ◽  
Hong-Phuc Do-Thi ◽  
Dietrich Schulte-Frohlinde ◽  
Helmut Sies
Keyword(s):  
Biological Activity ◽  
Singlet Oxygen ◽  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Break Formation

Intermediates in the ene reactions of singlet oxygen and N-phenyl-1,2,4-triazoline-3,5-dione with olefins

1990 ◽  
Vol 112 (9) ◽  
pp. 3607-3614 ◽  
Author(s):  
M. Orfanopoulos ◽  
I. Smonou ◽  
Christopher S. Foote
Keyword(s):  
Singlet Oxygen ◽  
Ene Reactions

The diverse bioactivity of α-mangostin and its therapeutic implications

2021 ◽  
Vol 13 (19) ◽  
pp. 1679-1694
Author(s):  
Tejashri Chavan ◽  
Aaron Muth
Keyword(s):  
Biological Activity ◽  
Natural Product ◽  
Secondary Metabolite ◽  
Bacterial Growth ◽  
Biological Effects ◽  
Structural Features ◽  
Therapeutic Implications ◽  
Specific Disease ◽  
Disease States ◽  
Key Pathways

α-Mangostin is a xanthone natural product isolated as a secondary metabolite from the mangosteen tree. It has attracted a great deal of attention due to its wide-ranging effects on certain biological activity, such as apoptosis, tumorigenesis, proliferation, metastasis, inflammation, oxidation, bacterial growth and metabolism. This review focuses on the key pathways directly affected by α-mangostin and how this varies between disease states. Insight is also provided, where investigated, into the key structural features of α-mangostin that produce these biological effects. The review then sheds light on the utility of α-mangostin as a investigational tool for certain diseases and demonstrate how future derivatives may increase selectivity and potency for specific disease states.

Mechanism of Ene Reactions of Singlet Oxygen. A Two-Step No-Intermediate Mechanism

2003 ◽  
Vol 125 (5) ◽  
pp. 1319-1328 ◽  
Author(s):  
Daniel A. Singleton ◽  
Chao Hang ◽  
Michael J. Szymanski ◽  
Matthew P. Meyer ◽  
Andrew G. Leach ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Ene Reactions ◽  
Intermediate Mechanism

scholarly journals Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

2011 ◽  
Vol 7 ◽  
pp. 1475-1485 ◽  
Author(s):  
Charles Dylan Turner ◽  
Marco A Ciufolini
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Fredericamycin A

This is a review of our efforts toward the synthesis of a group of natural products that display noteworthy biological activity: Fredericamycin A, nothapodytine B, and topopyrones B and D. In each case, directed aromatic functionalization methodology greatly facilitated the assembly of the key molecular subunits.

Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a

2014 ◽  
Vol 18 (03) ◽  
pp. 188-199 ◽  
Author(s):  
Áron Roxin ◽  
Thomas D. MacDonald ◽  
Gang Zheng
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Photodynamic Therapy ◽  
Natural Product ◽  
Synthesis And Characterization ◽  
Facile Synthesis ◽  
H Nmr ◽  
F Ring ◽  
C Nmr

Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is an analog of previously described natural exocyclic F-ring-containing porphyrins (1–4) and chlorins (5–10). The structure of 12 was confirmed using a combination of 1D 1 H NMR, 2D COSY 1 H NMR, Jmod 13 C NMR and HRMS analysis. The biological activity of 12 was explored, and we found that this compound does not possess strong antioxidant activity like its natural product counterparts, but is a capable photosensitizer for photodynamic therapy.

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