Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

2017 ◽  
Vol 110 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Zhiwen Shi ◽  
Xueyan Yang ◽  
Bin-Bin Li ◽  
Shuxia Chen ◽  
Luming Yang ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Novel Mutation ◽  
Chinese Han Population ◽  
Canonical Wnt Signaling ◽  
Chinese Han ◽  
Han Population ◽  
Canonical Wnt

scholarly journals Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities

genesis ◽  
2021 ◽  
Author(s):  
Alexandra J. Palmer ◽  
Dawn Savery ◽  
Valentina Massa ◽  
Andrew J. Copp ◽  
Nicholas D. E. Greene
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Interaction ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Association Study of PARD3 Gene Polymorphisms With Neural Tube Defects in a Chinese Han Population

2012 ◽  
Vol 19 (7) ◽  
pp. 764-771 ◽  
Author(s):  
Yonghui Gao ◽  
Xiaoli Chen ◽  
Shaofang Shangguan ◽  
Yihua Bao ◽  
Xiaoli Lu ◽  
...  
Keyword(s):  
Association Study ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association between ALDH1L1 gene polymorphism and neural tube defects in the Chinese Han population

2016 ◽  
Vol 37 (7) ◽  
pp. 1049-1054 ◽  
Author(s):  
Lihua Wu ◽  
Xiaolin Lu ◽  
Jin Guo ◽  
Ting Zhang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT

2018 ◽  
Vol 217 (10) ◽  
pp. 3683-3697 ◽  
Author(s):  
Erica J. Hutchins ◽  
Marianne E. Bronner
Keyword(s):  
Wnt Signaling ◽  
Neural Crest ◽  
Neural Tube ◽  
Epithelial To Mesenchymal Transition ◽  
Cranial Neural Crest ◽  
Canonical Wnt Signaling ◽  
Mesenchymal Transition ◽  
Molecular Rheostat ◽  
Timing Of Initiation ◽  
Canonical Wnt

Neural crest cells undergo a spatiotemporally regulated epithelial-to-mesenchymal transition (EMT) that proceeds head to tailward to exit from the neural tube. In this study, we show that the secreted molecule Draxin is expressed in a transient rostrocaudal wave that mirrors this emigration pattern, initiating after neural crest specification and being down-regulated just before delamination. Functional experiments reveal that Draxin regulates the timing of cranial neural crest EMT by transiently inhibiting canonical Wnt signaling. Ectopic maintenance of Draxin in the cranial neural tube blocks full EMT; while cells delaminate, they fail to become mesenchymal and migratory. Loss of Draxin results in premature delamination but also in failure to mesenchymalize. These results suggest that a pulse of intermediate Wnt signaling triggers EMT and is necessary for its completion. Taken together, these data show that transient secreted Draxin mediates proper levels of canonical Wnt signaling required to regulate the precise timing of initiation and completion of cranial neural crest EMT.

scholarly journals Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure

EBioMedicine ◽  
2015 ◽  
Vol 2 (6) ◽  
pp. 513-527 ◽  
Author(s):  
Chiharu Kimura-Yoshida ◽  
Kyoko Mochida ◽  
Kristina Ellwanger ◽  
Christof Niehrs ◽  
Isao Matsuo
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Neural Plate ◽  
Neural Tube Closure ◽  
Canonical Wnt Signaling ◽  
Fate Specification ◽  
Neural Plate Border ◽  
Canonical Wnt ◽  
Tube Closure

scholarly journals Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population

Oncotarget ◽  
2016 ◽  
Vol 7 (33) ◽  
pp. 52740-52750 ◽  
Author(s):  
Jing Tao ◽  
Yong-tao Wang ◽  
Mayila Abudoukelimu ◽  
Yi-ning Yang ◽  
Xiao-mei Li ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Genetic Variations ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association of Genetic Variants in Wnt Signaling Pathway with Tuberculosis in Chinese Han Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93841 ◽  
Author(s):  
Xuejiao Hu ◽  
Mengqiao Shang ◽  
Juan Zhou ◽  
Yuanxin Ye ◽  
Xiaojun Lu ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathway ◽  
Genetic Variants ◽  
Wnt Signaling Pathway ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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