scholarly journals Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

2005 ◽  
Vol 37 (5) ◽  
pp. 537-543 ◽  
Author(s):  
Matias Simons ◽  
Joachim Gloy ◽  
Athina Ganner ◽  
Axel Bullerkotte ◽  
Mikhail Bashkurov ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Gene Product ◽  
Molecular Switch ◽  
Type Ii

Genetic studies ofANKRD6as a molecular switch between Wnt signaling pathways in human neural tube defects

2014 ◽  
Vol 103 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Redouane Allache ◽  
Mingqin Wang ◽  
Patrizia De Marco ◽  
Elisa Merello ◽  
Valeria Capra ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Molecular Switch ◽  
Genetic Studies

scholarly journals IUGR disrupts the PPARγ‐Setd8‐H4K20me 1 and Wnt signaling pathways in the juvenile rat hippocampus

2014 ◽  
Vol 38 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Xingrao Ke ◽  
Bohan Xing ◽  
Baifeng Yu ◽  
Xing Yu ◽  
Amber Majnik ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Rat Hippocampus

scholarly journals Genetic Polymorphism in Extracellular Regulators of Wnt Signaling Pathway

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Garima Sharma ◽  
Ashish Ranjan Sharma ◽  
Eun-Min Seo ◽  
Ju-Suk Nam
Keyword(s):  
Genetic Polymorphism ◽  
Wnt Signaling ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
The Other ◽  
Present Review ◽  
Receptor Complex ◽  
Related Proteins ◽  
Related Association

The Wnt signaling pathway is mediated by a family of secreted glycoproteins through canonical and noncanonical mechanism. The signaling pathways are regulated by various modulators, which are classified into two classes on the basis of their interaction with either Wnt or its receptors. Secreted frizzled-related proteins (sFRPs) are the member of class that binds to Wnt protein and antagonizes Wnt signaling pathway. The other class consists of Dickkopf (DKK) proteins family that binds to Wnt receptor complex. The present review discusses the disease related association of various polymorphisms in Wnt signaling modulators. Furthermore, this review also highlights that some of the sFRPs and DKKs are unable to act as an antagonist for Wnt signaling pathway and thus their function needs to be explored more extensively.

ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster

Development ◽  
2001 ◽  
Vol 128 (15) ◽  
pp. 3001-3015 ◽  
Author(s):  
Pamela L. Bradley ◽  
Deborah J. Andrew
Keyword(s):  
Cell Migration ◽  
Wnt Signaling ◽  
Signaling Pathways ◽  
Egf Receptor ◽  
Tracheal System ◽  
Directed Cell Migration ◽  
Posterior Migration ◽  
And Function ◽  
Dorsal Epidermis ◽  
Anterior Posterior

During development, directed cell migration is crucial for achieving proper shape and function of organs. One well-studied example is the embryonic development of the larval tracheal system of Drosophila, in which at least four signaling pathways coordinate cell migration to form an elaborate branched network essential for oxygen delivery throughout the larva. FGF signaling is required for guided migration of all tracheal branches, whereas the DPP, EGF receptor, and Wingless/WNT signaling pathways each mediate the formation of specific subsets of branches. Here, we characterize ribbon, which encodes a BTB/POZ-containing protein required for specific tracheal branch migration. In ribbon mutant tracheae, the dorsal trunk fails to form, and ventral branches are stunted; however, directed migrations of the dorsal and visceral branches are largely unaffected. The dorsal trunk also fails to form when FGF or Wingless/WNT signaling is lost, and we show that ribbon functions downstream of, or parallel to, these pathways to promote anterior-posterior migration. Directed cell migration of the salivary gland and dorsal epidermis are also affected in ribbon mutants, suggesting that conserved mechanisms may be employed to orient cell migrations in multiple tissues during development.

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