Pharmacokinetics of drugs in blood VII: Unusual distribution and blood storage effect of vancomycin

1992 ◽  
Vol 13 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Wan G. Shin ◽  
Myung G. Lee ◽  
Min H. Lee ◽  
Nak D. Kim
Keyword(s):  
Storage Effect ◽  
Blood Storage ◽  
Unusual Distribution ◽  
Drugs In Blood

Pharmacokinetics of drugs in blood I. Unusual distribution of gentamicin

1981 ◽  
Vol 2 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Myung G. Lee ◽  
Mei-Ling Chen ◽  
Shiew-Mei Huang ◽  
Win L. Chiou
Keyword(s):  
Unusual Distribution ◽  
Drugs In Blood

Genomic insights from Monoglobus pectinilyticus: a pectin-degrading specialist bacterium in the human colon

2020 ◽  
Author(s):  
CC Kim ◽  
GR Healey ◽  
WJ Kelly ◽  
ML Patchett ◽  
Z Jordens ◽  
...  
Keyword(s):  
Cell Surface ◽  
Degradation Products ◽  
Model Organism ◽  
Human Colon ◽  
Surface Proteins ◽  
Human Gut ◽  
Pectate Lyases ◽  
Unusual Distribution ◽  
Degrading Bacteria ◽  
Acetyl Esterases

© 2019, International Society for Microbial Ecology. Pectin is abundant in modern day diets, as it comprises the middle lamellae and one-third of the dry carbohydrate weight of fruit and vegetable cell walls. Currently there is no specialized model organism for studying pectin fermentation in the human colon, as our collective understanding is informed by versatile glycan-degrading bacteria rather than by specialist pectin degraders. Here we show that the genome of Monoglobus pectinilyticus possesses a highly specialized glycobiome for pectin degradation, unique amongst Firmicutes known to be in the human gut. Its genome encodes a simple set of metabolic pathways relevant to pectin sugar utilization, and its predicted glycobiome comprises an unusual distribution of carbohydrate-active enzymes (CAZymes) with numerous extracellular methyl/acetyl esterases and pectate lyases. We predict the M. pectinilyticus degradative process is facilitated by cell-surface S-layer homology (SLH) domain-containing proteins, which proteomics analysis shows are differentially expressed in response to pectin. Some of these abundant cell surface proteins of M. pectinilyticus share unique modular organizations rarely observed in human gut bacteria, featuring pectin-specific CAZyme domains and the cell wall-anchoring SLH motifs. We observed M. pectinilyticus degrades various pectins, RG-I, and galactan to produce polysaccharide degradation products (PDPs) which are presumably shared with other inhabitants of the human gut microbiome (HGM). This strain occupies a new ecological niche for a primary degrader specialized in foraging a habitually consumed plant glycan, thereby enriching our understanding of the diverse community profile of the HGM.

scholarly journals Effects of whole blood storage in a polyolefin blood bag on platelets for acute normovolemic hemodilution

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yutaka Murata ◽  
Eriko Kusudo ◽  
Shuji Kawamoto ◽  
Kazuhiko Fukuda
Keyword(s):  
Polyvinyl Chloride ◽  
Conventional Method ◽  
Whole Blood ◽  
Gas Permeability ◽  
Acute Normovolemic Hemodilution ◽  
Blood Storage ◽  
Cell Parameters ◽  
Storage Method ◽  
Normovolemic Hemodilution ◽  
Induced Aggregation

AbstractAcute normovolemic hemodilution (ANH) is a potential transfusion method for platelets, as well as for red blood cells. However, previous studies have shown that whole blood storage in ANH decreases platelet aggregability by 14.7–76.3% and that this decrease is not recovered by reinfusion. We investigated whether a new whole blood storage method for 6 h using a polyolefin bag, based on the platelet concentrates storage method, would maintain platelet function better than the conventional method using a polyvinyl chloride bag. We demonstrated that storage of whole blood in a polyolefin bag maintained ADP-induced aggregation rates at more than twofold higher than those in a polyvinyl chloride bag, and also significantly suppressed P-selectin expression, a platelet activation marker (ADP-induced aggregation rates: 24.6 ± 5.1% vs. 51.7 ± 11.5%, p = 0.002; P-selectin expression; 50.3 ± 8.4MFI vs. 31.6 ± 9.3MFI, p = 0.018). These results could be attributed to the high gas permeability of polyolefin, which lowered PCO2 and maintained a high pH with or without agitation. There were no significant changes in platelet count and red blood cell parameters due to the storage methods. Our results suggest that ANH using polyolefin bags is advantageous in improving hemostatic function compared to the conventional method.

Maternal understanding of commercial cord blood storage for their offspring - a survey among pregnant women in Hong Kong

2011 ◽  
Vol 90 (9) ◽  
pp. 1005-1009 ◽  
Author(s):  
STEPHEN SIK HUNG SUEN ◽  
TERENCE T LAO ◽  
OI KA CHAN ◽  
THOMAS KAM ON KOU ◽  
SAMMY CHUNG SUM CHAN ◽  
...  
Keyword(s):  
Hong Kong ◽  
Cord Blood ◽  
Pregnant Women ◽  
Blood Storage
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