A new synthetic approach to asymmetric amphiphilic ABA′ block copolymers by ATRP and click reactions

2009 ◽  
Vol 111 (1) ◽  
pp. 560-565 ◽  
Author(s):  
Xiaohua He ◽  
Liyuan Liang ◽  
Kai Wang ◽  
Shaoliang Lin ◽  
Deyue Yan ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Synthetic Approach ◽  
Click Reactions

Click Reactions in Chemistry of Triterpenes - Advances Towards Development of Potential Therapeutics

2018 ◽  
Vol 25 (5) ◽  
pp. 636-658 ◽  
Author(s):  
Jan Pokorny ◽  
Lucie Borkova ◽  
Milan Urban
Keyword(s):  
Biological Activities ◽  
Synthetic Approach ◽  
Clinical Use ◽  
New Approach ◽  
Click Reactions ◽  
Drug Candidates ◽  
The Past ◽  
Low Toxicity ◽  
New Compounds ◽  
Potential Therapeutics

Triterpenoids are natural compounds with a large variety of biological activities such as anticancer, antiviral, antibacterial, antifungal, antiparazitic, antiinflammatory and others. Despite their low toxicity and simple availability from the natural resources, their clinical use is still severely limited by their higher IC50 and worse pharmacological properties than in the currently used therapeutics. This fact encouraged a number of researchers to develop new terpenic derivatives more suitable for the potential clinical use. This review summarizes a new approach to improve both, the activity and ADME-Tox properties by connecting active terpenes to another modifying molecules using click reactions. Within the past few years, this synthetic approach was well explored yielding a lot of great improvements of the parent compounds along with some less successful attempts. A large quantity of the new compounds presented here are superior in both activity and ADME-Tox properties to their parents. This review should serve the researchers who need to promote their hit triterpenic structures towards their clinical use and it is intended as a guide for the chemical synthesis of better drug candidates.

Selective Cell Adhesion and Biosensing Applications of Bio-Active Block Copolymers Prepared by CuAAC/Thiol-ene Double Click Reactions

2015 ◽  
Vol 15 (9) ◽  
pp. 1233-1241 ◽  
Author(s):  
Gizem Oyman Eyrilmez ◽  
Sean Doran ◽  
Eljesa Murtezi ◽  
Bilal Demir ◽  
Dilek Odaci Demirkol ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Block Copolymers ◽  
Click Reactions ◽  
Active Block

An easy way to the preparation of multi-miktoarm star block copolymers via sequential double click reactions

2010 ◽  
Vol 1 (5) ◽  
pp. 621 ◽  
Author(s):  
Aydan Dag ◽  
Hakan Durmaz ◽  
Volkan Kirmizi ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
Click Reactions ◽  
Miktoarm Star ◽  
Star Block Copolymers

A Versatile Synthetic Approach to Polypeptide Based Rod−Coil Block Copolymers by Click Chemistry

2007 ◽  
Vol 40 (16) ◽  
pp. 5653-5661 ◽  
Author(s):  
Willy Agut ◽  
Daniel Taton ◽  
Sébastien Lecommandoux
Keyword(s):  
Block Copolymers ◽  
Click Chemistry ◽  
Synthetic Approach

Rod-coil block copolymers: An iterative synthetic approach via living free-radical procedures

2003 ◽  
Vol 41 (22) ◽  
pp. 3640-3656 ◽  
Author(s):  
Padma Gopalan ◽  
Xuefa Li ◽  
Mingqi Li ◽  
Christopher K. Ober ◽  
Chad P. Gonzales ◽  
...  
Keyword(s):  
Free Radical ◽  
Block Copolymers ◽  
Synthetic Approach

scholarly journals Novel Synthetic Approach to the Blocksil Siloxane Copolymers

INEOS OPEN ◽  
2021 ◽  
Author(s):  
N. V. Sergienko ◽  
◽  
N. V. Polshchikova ◽  
M. I. Buzin ◽  
V. M. Kotov ◽  
...  
Keyword(s):  
Thermal Properties ◽  
Block Copolymers ◽  
Synthetic Approach

A novel synthetic approach to the block copolymers bearing diorganosiloxane and organosilsesquioxane blocks is suggested that obviates the need for using organochlorosilane precursors. A series of the polymers with different combinations of oligodimethylsiloxane and oligomethylphenylsiloxane flexible blocks with methylsilsesquioxane and phenylsilsesquioxane rigid blocks is prepared. The thermal properties of the films obtained from these polymers are explored.

scholarly journals Rational linkage of magnetic molecules using click chemistry

2015 ◽  
Vol 51 (30) ◽  
pp. 6524-6527 ◽  
Author(s):  
Christian Plenk ◽  
Jasmin Krause ◽  
Martin Beck ◽  
Eva Rentschler
Keyword(s):  
Quantum Computing ◽  
Click Chemistry ◽  
Synthetic Approach ◽  
Click Reactions ◽  
Magnetic Molecules ◽  
Molecular Arrangement ◽  
First Time

Established CuAAC click reactions are used for the first time to assemble magnetic molecules to an extended molecular arrangement. This novel synthetic approach is expected to be a general approach to link SMMs as an important precondition to realize quantum computing.

Cyclic homo and block copolymers through sequential double click reactions

2010 ◽  
Vol 48 (22) ◽  
pp. 5083-5091 ◽  
Author(s):  
Hakan Durmaz ◽  
Aydan Dag ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
Click Reactions

Modular Synthesis of Polyferrocenylsilane Block Copolymers by Cu-Catalyzed Alkyne/Azide “Click” Reactions

2013 ◽  
Vol 46 (4) ◽  
pp. 1296-1304 ◽  
Author(s):  
Meng Zhang ◽  
Paul A. Rupar ◽  
Chun Feng ◽  
Kaixiang Lin ◽  
David J. Lunn ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Click Reactions ◽  
Modular Synthesis

Synthesis and properties of clickable A(B-b-C)20 miktoarm star-shaped block copolymers with a terminal alkyne group

2015 ◽  
Vol 6 (21) ◽  
pp. 3913-3917 ◽  
Author(s):  
Bing Huang ◽  
Min Chen ◽  
Shuxue Zhou ◽  
Limin Wu
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Terminal Alkyne ◽  
Click Reactions ◽  
Miktoarm Star

A novel and reactive A(B-b-C)20 miktoarm star-shaped block copolymer has been successfully synthesized through ATRP reaction combined with click reactions.

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