Polymer matrix controlled release systems: Influence of polymer carrier and temperature on water uptake and protein release

1992 ◽  
Vol 46 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Norman F. Sheppard ◽  
M. Yvette Madrid ◽  
Robert Langer
Keyword(s):  
Controlled Release ◽  
Water Uptake ◽  
Polymer Matrix ◽  
Protein Release ◽  
Polymer Carrier

Lysozyme Release from Lipid-Based Implants

2014 ◽  
Vol 1060 ◽  
pp. 83-86
Author(s):  
Joana Portugal Mota ◽  
Alexandre Campos ◽  
Duangratana Shuwisitkul ◽  
Nuno Saraiva ◽  
Marisa Nicolai
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Smooth Surface ◽  
Surface Protein ◽  
Protein Release ◽  
Protein Loading ◽  
Loading Efficiency ◽  
Model Protein ◽  
Preparation Techniques ◽  
Potential Use

To better understand lipid-based implants applied to proteins, lysozyme was used as a model protein and was loaded into lipid-based implants in different contents. Cylindrical and spherical implants loaded with lysozyme presented a smooth surface. Protein loading efficiency decreased with increasing lysozyme loading. Lysozyme kept its activity after different implant preparation techniques. Drug release tremendously increased by increasing protein loading from 8.9 to 13.7% (w/w), for cylindrical implants. Lysozyme release was faster from cylindrical implants when compared with the spherical ones. Furthermore, by increasing the hydrophobicity of the lipid, protein release decreased. This study demonstrates the potential use of lipid-based implants for the controlled release of proteins.

scholarly journals Degradable Controlled Release Fertilizer Composite Prepared via Extrusion: Fabrication, Characterization, and Release Mechanisms

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 301 ◽  
Author(s):  
Siwen Bi ◽  
Vincenzo Barinelli ◽  
Margaret J. Sobkowicz
Keyword(s):  
Controlled Release ◽  
Biodegradable Polymers ◽  
Polymer Matrix ◽  
Phosphorus Deficiency ◽  
Release Kinetics ◽  
Phosphate Fertilizer ◽  
Water Soluble ◽  
Butylene Succinate ◽  
Urea Phosphate ◽  
Erosion Mechanisms

In this work, biodegradable polymers were melt compounded with urea phosphate to fabricate “smart fertilizers” for sustainable agriculture. Urea phosphate (UP) is typically applied as a water-soluble fertilizer to treat phosphorus deficiency in high pH soils. Due to the low diffusion rate of phosphate through slow-release fertilizer coatings, phosphate supply has been considered the “bottleneck” for nitrogen–phosphorous–potassium (NPK) nutrients supply. We study the influence of polymer matrix structure on release kinetics in deionized water using novel polyesters including poly (hexamethylene succinate) (PHS), poly (30% butylene succinate-co-70% hexamethylene succinate) (PBHS 30/70), and PBHS 70/30. Melt processed composites of UP and polyester were analyzed to determine UP loading efficiency and dispersion and distribution of the salt in the polymer matrix. A combined empirical model involving diffusion and erosion mechanisms was found have a good agreement with the experimental release curve. This work provides a solution for environmentally friendly controlled release phosphate fertilizer with good release performance using bio-based and biodegradable polymers.

Micromachined silicon structures for modelling polymer matrix controlled release systems

1996 ◽  
Vol 42 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Norman F. Sheppard ◽  
David J. Mears ◽  
Scott W. Straka
Keyword(s):  
Controlled Release ◽  
Polymer Matrix ◽  
Silicon Structures

Prolonged Regional Nerve Blockade by Controlled Release of Local Anesthetic from a Biodegradable Polymer Matrix

1993 ◽  
Vol 79 (2) ◽  
pp. 340-346 ◽  
Author(s):  
David B. Masters ◽  
Charles B. Berde ◽  
Sanjoy K. Dutta ◽  
Chauncey T. Griggs ◽  
Delphine Hu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymer Matrix ◽  
Local Anesthetic ◽  
Biodegradable Polymer ◽  
Nerve Blockade

scholarly journals Dually degradable click hydrogels for controlled degradation and protein release

2014 ◽  
Vol 2 (34) ◽  
pp. 5511-5521 ◽  
Author(s):  
Prathamesh M. Kharkar ◽  
April M. Kloxin ◽  
Kristi L. Kiick
Keyword(s):  
Controlled Release ◽  
Bond Cleavage ◽  
Ester Hydrolysis ◽  
Protein Release

Crosslinks that can undergo click bond cleavage and ester hydrolysis were incorporated to design glutathione-sensitive, dually degradable hydrogels for degradation-mediated, controlled release of cargo molecules.

Mechanical deformation of polymer matrix controlled release devices modulates drug release

1992 ◽  
Vol 26 (12) ◽  
pp. 1619-1631 ◽  
Author(s):  
Elazer R. Edelman ◽  
Anthony Fiorino ◽  
Alan Grodzinsky ◽  
Robert Langer
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Polymer Matrix ◽  
Mechanical Deformation ◽  
Release Devices

Photothermal triggered protein release from an injectable polycaprolactone-based microspherical depot

2017 ◽  
Vol 5 (20) ◽  
pp. 3634-3639
Author(s):  
Chunling Ge ◽  
Johan S. Basuki ◽  
Jacinta White ◽  
Ruixia Hou ◽  
Yong Peng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Visible Light ◽  
Protein Release ◽  
Biologically Active

Visible light mediated controlled release of biologically active enzymes was confirmed by released horseradish peroxidase's ability to ameliorate H2O2 cytotoxicity in vitro.

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