Comments on “Modeling the controlled release of drug embedded in a plate-like polymer matrix” by Lin et al.

2005 ◽  
Vol 60 (24) ◽  
pp. 7172-7173 ◽  
Author(s):  
Ping I. Lee
Keyword(s):  
Controlled Release ◽  
Polymer Matrix

scholarly journals Degradable Controlled Release Fertilizer Composite Prepared via Extrusion: Fabrication, Characterization, and Release Mechanisms

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 301 ◽  
Author(s):  
Siwen Bi ◽  
Vincenzo Barinelli ◽  
Margaret J. Sobkowicz
Keyword(s):  
Controlled Release ◽  
Biodegradable Polymers ◽  
Polymer Matrix ◽  
Phosphorus Deficiency ◽  
Release Kinetics ◽  
Phosphate Fertilizer ◽  
Water Soluble ◽  
Butylene Succinate ◽  
Urea Phosphate ◽  
Erosion Mechanisms

In this work, biodegradable polymers were melt compounded with urea phosphate to fabricate “smart fertilizers” for sustainable agriculture. Urea phosphate (UP) is typically applied as a water-soluble fertilizer to treat phosphorus deficiency in high pH soils. Due to the low diffusion rate of phosphate through slow-release fertilizer coatings, phosphate supply has been considered the “bottleneck” for nitrogen–phosphorous–potassium (NPK) nutrients supply. We study the influence of polymer matrix structure on release kinetics in deionized water using novel polyesters including poly (hexamethylene succinate) (PHS), poly (30% butylene succinate-co-70% hexamethylene succinate) (PBHS 30/70), and PBHS 70/30. Melt processed composites of UP and polyester were analyzed to determine UP loading efficiency and dispersion and distribution of the salt in the polymer matrix. A combined empirical model involving diffusion and erosion mechanisms was found have a good agreement with the experimental release curve. This work provides a solution for environmentally friendly controlled release phosphate fertilizer with good release performance using bio-based and biodegradable polymers.

Micromachined silicon structures for modelling polymer matrix controlled release systems

1996 ◽  
Vol 42 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Norman F. Sheppard ◽  
David J. Mears ◽  
Scott W. Straka
Keyword(s):  
Controlled Release ◽  
Polymer Matrix ◽  
Silicon Structures

Prolonged Regional Nerve Blockade by Controlled Release of Local Anesthetic from a Biodegradable Polymer Matrix

1993 ◽  
Vol 79 (2) ◽  
pp. 340-346 ◽  
Author(s):  
David B. Masters ◽  
Charles B. Berde ◽  
Sanjoy K. Dutta ◽  
Chauncey T. Griggs ◽  
Delphine Hu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymer Matrix ◽  
Local Anesthetic ◽  
Biodegradable Polymer ◽  
Nerve Blockade

Mechanical deformation of polymer matrix controlled release devices modulates drug release

1992 ◽  
Vol 26 (12) ◽  
pp. 1619-1631 ◽  
Author(s):  
Elazer R. Edelman ◽  
Anthony Fiorino ◽  
Alan Grodzinsky ◽  
Robert Langer
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Polymer Matrix ◽  
Mechanical Deformation ◽  
Release Devices

scholarly journals Biodegradable Blends of Grafted Dextrin with PLGA-block-PEG Copolymer as a Carrier for Controlled Release of Herbicides into Soil

Materials ◽  
2020 ◽  
Vol 13 (4) ◽  
pp. 832 ◽  
Author(s):  
Kamila Lewicka ◽  
Piotr Rychter ◽  
Małgorzata Pastusiak ◽  
Henryk Janeczek ◽  
Piotr Dobrzynski
Keyword(s):  
Controlled Release ◽  
Polymer Matrix ◽  
Enzymatic Degradation ◽  
Plant Protection ◽  
Degradation Products ◽  
The Matrix ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Unchanged Form ◽  
Potential Use

The presented work aimed to test influence of poly(L-lactide-co-glycolide)-block-poly (ethylene oxide) copolymer modification by blending with grafted dextrin or maltodextrin on the course of degradation in soil and the usefulness of such material as a matrix in the controlled release of herbicides. The modification should be to obtain homogenous blends with better susceptibility to enzymatic degradation. Among all tested blends, which were proposed as a carrier for potential use in the controlled release of plant protection agents, PLGA-block-PEG copolymer blended with grafted dextrin yielded very promising results for their future applications, and what is very importantly proposed formulations provide herbicides in unchanged form into soil within few months of release. The modification PLAGA/PEG copolymer by blending with modificated dextrins affects the improvement of the release profile. The weekly release rates for both selected herbicides (metazachlor and pendimethalin) were constant for a period of 12 weeks. Enzymatic degradation of modified dextrin combined with leaching of the degradation products into medium caused significant erosion of the polymer matrix, thereby leading to acceleration of water diffusion into the polymer matrix and allowing for easier leaching of herbicides outside the matrix.

Controlled Release of Tebuconazole from a Polymer Matrix Microparticle:  Release Kinetics and Length of Efficacy

2004 ◽  
Vol 52 (15) ◽  
pp. 4814-4820 ◽  
Author(s):  
Jawed Asrar ◽  
Yiwei Ding ◽  
Rita E. La Monica ◽  
Linda C. Ness
Keyword(s):  
Controlled Release ◽  
Polymer Matrix ◽  
Release Kinetics

Modeling the controlled release of drug embedded in a plate-like polymer matrix

2005 ◽  
Vol 60 (5) ◽  
pp. 1295-1301 ◽  
Author(s):  
Sung-Hwa Lin ◽  
Jyh-Ping Hsu ◽  
Shiojenn Tseng
Keyword(s):  
Controlled Release ◽  
Polymer Matrix
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