Biomedical Applications: Multifunctional Cationic Poly(p-phenylene vinylene) Polyelectrolytes for Selective Recognition, Imaging, and Killing of Bacteria Over Mammalian Cells (Adv. Mater. 41/2011)

2011 ◽  
Vol 23 (41) ◽  
pp. 4804-4804
Author(s):  
Chunlei Zhu ◽  
Qiong Yang ◽  
Libing Liu ◽  
Fengting Lv ◽  
Shayu Li ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Biomedical Applications ◽  
Selective Recognition ◽  
Phenylene Vinylene ◽  
Recognition Imaging

Multifunctional Cationic Poly(p-phenylene vinylene) Polyelectrolytes for Selective Recognition, Imaging, and Killing of Bacteria Over Mammalian Cells

2011 ◽  
Vol 23 (41) ◽  
pp. 4805-4810 ◽  
Author(s):  
Chunlei Zhu ◽  
Qiong Yang ◽  
Libing Liu ◽  
Fengting Lv ◽  
Shayu Li ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Selective Recognition ◽  
Phenylene Vinylene ◽  
Recognition Imaging

Bifunctionally engineered polyethylenimines as efficient DNA carriers and antibacterials against resistant pathogens

2018 ◽  
Vol 33 (3) ◽  
pp. 363-379
Author(s):  
Z Ahmadi ◽  
D Jha ◽  
B Kumar ◽  
HK Gautam ◽  
Pradeep Kumar
Keyword(s):  
Gel Electrophoresis ◽  
Mammalian Cells ◽  
Biomedical Applications ◽  
Pathogenic Bacteria ◽  
Low Molecular Weight ◽  
High Cell ◽  
Gene Delivery Vectors ◽  
Efficient Gene ◽  
Resistant Strains ◽  
Better Than

In this study, we have designed and developed two series of bifunctional conjugates by tethering polyethylenimine with streptomycin. By varying the amount of streptomycin, conjugates, polyethylenimine-streptomycin, have been synthesized and characterized spectroscopically. Gel electrophoresis assay revealed a slight decrease in the cationic charge density on the conjugates as these retarded the mobility of pDNA at higher w/w ratios. Further, transfection studies showed that both the series of conjugates transfected the mammalian cells efficiently with low-molecular weight polyethylenimine-streptomycin conjugates were more competent (∼9-fold enhancement with respect to native bPEI) exhibiting high cell viability too. Besides, both the series of conjugates displayed excellent antibacterial activity on pathogenic bacteria, even better than native streptomycin on resistant strains. Altogether, these results ensure the promising potential of the projected bifunctional conjugates as safe and efficient gene delivery vectors as well as antibacterials for future biomedical applications.

scholarly journals Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 789 ◽  
Author(s):  
Regina Menezes ◽  
Alexandre Foito ◽  
Carolina Jardim ◽  
Inês Costa ◽  
Gonçalo Garcia ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Biomedical Applications ◽  
Therapeutic Potential ◽  
Integrative Approach ◽  
Natural Sources ◽  
Analysis And Evaluation ◽  
Cellular Assays ◽  
Health Promoting ◽  
Rubus Species ◽  
Anti Inflammatory

Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols’ bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin–hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin–hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.

scholarly journals Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System

2019 ◽  
Vol 9 (5) ◽  
pp. 825 ◽  
Author(s):  
Nemany Hanafy ◽  
Stefano Leporatti ◽  
Maged El-Kemary
Keyword(s):  
Drug Delivery ◽  
Biological Activity ◽  
Mammalian Cells ◽  
Biomedical Applications ◽  
Biological Fluids ◽  
Medical Applications ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Hydrogel Formulation

Hydrogels are widely used materials which have many medical applications. Their ability to absorb aqueous solutions and biological fluids gives them innovative characterizations resulting in increased compatibility with biological activity. In this sense, they are used extensively for encapsulation of several targets such as biomolecules, viruses, bacteria, and mammalian cells. Indeed, many methods have been published which are used in hydrogel formulation and biomedical encapsulations involving several cross-linkers. This system is still rich with the potential of undiscovered features. The physicochemical properties of polymers, distinguished by their interactions with biological systems into mucoadhesive, gastro-adhesive, and stimuli responsive polymers. Hydrogel systems may be assembled as tablets, patches, gels, ointments, and films. Their potential to be co-formulated as nanoparticles extends the limits of their assembly and application. In this review, mucoadhesive nanoparticles and their importance for biomedical applications are highlighted with a focus on mechanisms of overcoming mucosal resistance.

Bioorthogonal chemistry for selective recognition, separation and killing bacteria over mammalian cells

2016 ◽  
Vol 52 (17) ◽  
pp. 3482-3485 ◽  
Author(s):  
Zhenhua Li ◽  
Zhen Liu ◽  
Zhaowei Chen ◽  
Enguo Ju ◽  
Wei Li ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Mammalian Cells ◽  
Selective Recognition ◽  
Bioorthogonal Chemistry ◽  
New Strategy

We report a new strategy for selective recognition, separation and killing bacteria using metabolic engineering and bioorthogonal chemistry.

Biomimetic Principles to Develop Blood Compatible Surfaces

2017 ◽  
Vol 40 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Vladislav Semak ◽  
Michael B. Fischer ◽  
Viktoria Weber
Keyword(s):  
Surface Functionalization ◽  
Mammalian Cells ◽  
Membrane Structure ◽  
Biomedical Applications ◽  
Nonspecific Adsorption ◽  
Biomaterial Surface ◽  
Biomaterial Surfaces ◽  
Biomedical Technologies ◽  
Surface Patterns ◽  
Over Time

Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans – both of which are inspired by the membrane structure of mammalian cells – and discuss their potential for biomedical applications.

Synthesis Fe-Ni Alloy Magnetic Nanoparticles for Biomedical Applications

2006 ◽  
Author(s):  
Ming-Fong Tai ◽  
Jong-Kai Hsiao ◽  
Hon-Man Liu ◽  
Shio-Chao Lee ◽  
Shin-Tai Chen
Keyword(s):  
Magnetic Nanoparticles ◽  
Saturation Magnetization ◽  
Mammalian Cells ◽  
Biomedical Applications ◽  
Magnetic Beads ◽  
Combustion Method ◽  
Chemical Precipitation ◽  
Mri Contrast Agent ◽  
Precipitation Method

In this investigation, we synthesize FeNi alloy magnetic nanoparticles (MNPs) by using both chemical precipitation and combustion methods. The FeNi MNPs prepared by combustion method have a rather high saturation magnetization Ms of ∼180 emu/g and a coercivity field Hc of near zero. The functionalized FeNi MNPs which were coated with biocompatible polyethyleneimine (PEI) polymer have also been synthesized. We demonstrated that the PEI coated FeNi MNPs can enter the mammalian cells in vitro and can be used as a magnetic resonance imagine (MRI) contrast agent. The results demonstrated that FeNi MNPs potentially could be applied in the biomedical field. To prepare a higher quality and well controlled Fe-Ni MNPs, we also developed a thermal reflux chemical precipitation method to synthesize FeNi3 alloy MNPs. The precursor chemicals of Fe(acac)3 and Ni(acac)2 in a molecular ratio of 1:3 reacted in octyl ether solvent at the boiling point of solvent (∼300°C) by the thermal reflux process. The 1,2-hexadecandiol and tri-n-octylphosphine oxide (TOPO) were used as reducer and surfactant, respectively. The chemically precipitated FeNi3 MNPs are well dispensed and have well-controlled particle sizes around 10–20 nm with a very narrow size distribution (± 1.2 nm). The highly monodispersive FeNi3 NPs present good uniformity in particle shape and crystallinity on particle surfaces. The MNPs exhibit well soft magnetism with saturation magnetization of ∼61 emu/g and Hc ∼ 0. The functionalized magnetic beads with biocompatible polymer coated on MNPs are also generated completed for biomedical applications.

3D hierarchical tubular micromotors with highly selective recognition and capture for antibiotics

2020 ◽  
Vol 8 (5) ◽  
pp. 2809-2819 ◽  
Author(s):  
Xingmei Bing ◽  
Xiaolei Zhang ◽  
Jia Li ◽  
Dickon H. L. Ng ◽  
Wenning Yang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Scientific Community ◽  
Selective Recognition

Self-propelled micro/nanomotors attract a great deal of attention from the scientific community due to their great potential in environmental and biomedical applications.

Quantum dots modified with quaternized poly(dimethylaminoethyl methacrylate) for selective recognition and killing of bacteria over mammalian cells

The Analyst ◽  
2016 ◽  
Vol 141 (11) ◽  
pp. 3328-3336 ◽  
Author(s):  
Qin Tu ◽  
Chao Ma ◽  
Chang Tian ◽  
Maosen Yuan ◽  
Xiang Han ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Click Chemistry ◽  
Mammalian Cells ◽  
Selective Recognition ◽  
Dimethylaminoethyl Methacrylate

Quantum dots modified with quaternized poly(dimethylaminoethyl methacrylate) were prepared by simple copper-free click chemistry for the selective recognition and killing of bacterial over mammalian cells.

scholarly journals Selective recognition of anionic cell membranes using targeted liposomes coated with zinc(ii)-bis(dipicolylamine) affinity units

2014 ◽  
Vol 12 (30) ◽  
pp. 5645-5655 ◽  
Author(s):  
Serhan Turkyilmaz ◽  
Douglas R. Rice ◽  
Rachael Palumbo ◽  
Bradley D. Smith
Keyword(s):  
Mammalian Cells ◽  
Cell Membranes ◽  
Selective Recognition ◽  
Membrane Surfaces

Liposomes containing phospholipid-PEG conjugates with terminal zinc(ıı)-bis(dipicolylamine) affinity units selectively target anionic membrane surfaces including the exterior of bacterial and dead/dying mammalian cells.

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