Self-Assembling Polymer–Peptide Conjugates: Nanostructural Tailoring

2004 ◽  
Vol 16 (11) ◽  
pp. 907-910 ◽  
Author(s):  
J. H. Collier ◽  
P. B. Messersmith
Keyword(s):  
Peptide Conjugates ◽  
Self Assembling

scholarly journals Diphenylalanine Motif Drives Self‐assembling in Hybrid PNA‐peptide Conjugates

2021 ◽  
Author(s):  
Carlo Diaferia ◽  
Concetta Avitabile ◽  
Marilisa Leone ◽  
Enrico Gallo ◽  
Michele Saviano ◽  
...  
Keyword(s):  
Peptide Conjugates ◽  
Self Assembling

An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

2019 ◽  
Vol 55 (98) ◽  
pp. 14852-14855 ◽  
Author(s):  
Can Wu ◽  
Jing Liu ◽  
Xuan Tang ◽  
Ziran Zhai ◽  
Keming Xu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Delivery System ◽  
Peptide Conjugates ◽  
Self Assembling

A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells.

Thiol coupling based synthesis of temperature-sensitive polymer–peptide conjugates with controlled architecture.

2012 ◽  
Vol 1418 ◽  
Author(s):  
Jean-Baptiste Guilbaud ◽  
Aline F. Miller ◽  
Alberto Saiani
Keyword(s):  
Phase Transition ◽  
Molecular Weight ◽  
Low Temperature ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Temperature Sensitive ◽  
Thermoresponsive Polymer ◽  
Peptide Conjugates ◽  
Synthetic Strategy ◽  
Self Assembling

ABSTRACTA synthetic strategy to couple selectively an ionic complementary thiol modified octapeptide, that is able to gel at low temperature, to the thermoresponsive polymer poly(N-isopropylacrylamide) (pNIPAAm) with controlled molecular weight and narrow polydispersity is described. The polymer was synthesized by atom transfer radical polymerization (ATRP) affording halogen functionalized chain ends. This allowed subsequent coupling to a thiol terminated ionic complementary octapeptide via nucleophile substitution. Results indicated that the peptide was covalently attached to the polymer and that both the coil-globule phase transition of pNIPAAm and the gelation properties of the peptide were retained in the conjugated product. This method provides a versatile route for the synthesis of a range of bioconjugate materials with controlled architecture and dual self-assembling and thermoresponsive behavior.

Self-assembling peptide-based nanodrug delivery systems

2019 ◽  
Vol 7 (12) ◽  
pp. 4888-4911 ◽  
Author(s):  
Qian Wang ◽  
Nan Jiang ◽  
Bo Fu ◽  
Fan Huang ◽  
Jianfeng Liu
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Delivery Systems ◽  
Present Review ◽  
Peptide Conjugates ◽  
Nanodrug Delivery ◽  
Self Assembling ◽  
Small Molecule Drugs ◽  
Delivery Strategies

The present review outlines the methods designing self-assembling peptide-based NDDs for small molecule drugs, with an emphasis on the different drug delivery strategies and their applications in using peptides and peptide conjugates.

Co-assembled supramolecular hydrogels of doxorubicin and indomethacin-derived peptide conjugates for synergistic inhibition of cancer cell growth

2019 ◽  
Vol 55 (30) ◽  
pp. 4411-4414 ◽  
Author(s):  
Leixia Mei ◽  
Suyun He ◽  
Ziqi Liu ◽  
Keming Xu ◽  
Wenying Zhong
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Peptide Conjugates ◽  
Synergistic Inhibition ◽  
Self Assembling

Co-assembly of doxorubicin and a NSAID-based self-assembling peptide conjugate promotes synergistic inhibition of cancer cell growth.

scholarly journals Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials

2017 ◽  
Vol 15 (28) ◽  
pp. 5867-5876 ◽  
Author(s):  
Charlotte J. C. Edwards-Gayle ◽  
Ian W. Hamley
Keyword(s):  
Self Assembly ◽  
Bioactive Peptides ◽  
Peptide Conjugates ◽  
Amphiphilic Peptides ◽  
Peptide Mimetic ◽  
Self Assembling ◽  
Potential Applications

Self-assembling peptide and peptide conjugates have attracted great attention due to their biocompatibility, biodegradability and biofunctionality. This review covers self-assembly of amphiphilic peptides and peptide mimetic materials, as well as their potential applications.

Supramolecular control of self-assembling terthiophene–peptide conjugates through the amino acid side chain

2012 ◽  
Vol 48 (78) ◽  
pp. 9711 ◽  
Author(s):  
Jessica A. Lehrman ◽  
Honggang Cui ◽  
Wei-Wen Tsai ◽  
Tyson J. Moyer ◽  
Samuel I. Stupp
Keyword(s):  
Amino Acid ◽  
Side Chain ◽  
Amino Acid Side Chain ◽  
Peptide Conjugates ◽  
Self Assembling ◽  
Supramolecular Control

Torus Circumference and Thickness Parameters From a Linear DNA Size Series Suggest How Toruses Self-Assemble

1985 ◽  
Vol 43 ◽  
pp. 522-523
Author(s):  
George C. Ruben ◽  
Kenneth A. Marx
Keyword(s):  
Tertiary Structure ◽  
Dna Complexes ◽  
Tertiary Structures ◽  
Self Assembling ◽  
Double Stranded Dna ◽  
Calf Thymus ◽  
Dna Organization ◽  
Condensed Dna ◽  
Dna Size

Certain double stranded DNA bacteriophage and viruses are thought to have their DNA organized into large torus shaped structures. Morphologically, these poorly understood biological DNA tertiary structures resemble spermidine-condensed DNA complexes formed in vitro in the total absence of other macromolecules normally synthesized by the pathogens for the purpose of their own DNA packaging. Therefore, we have studied the tertiary structure of these self-assembling torus shaped spermidine- DNA complexes in a series of reports. Using freeze-etch, low Pt-C metal (10-15Å) replicas, we have visualized the microscopic DNA organization of both calf Thymus( CT) and linear 0X-174 RFII DNA toruses. In these structures DNA is circumferentially wound, continuously, around the torus into a semi-crystalline, hexagonal packed array of parallel DNA helix sections.

Structure–property studies of self-assembling [n.n]paracyclophanes

2020 ◽  
Author(s):  
Will R Henderson ◽  
Danielle E. Fagnani ◽  
Yu Zhu ◽  
Guancen Liu ◽  
Ronald K. Castellano
Keyword(s):  
Structure Property ◽  
Self Assembling
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