An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

2019 ◽  
Vol 55 (98) ◽  
pp. 14852-14855 ◽  
Author(s):  
Can Wu ◽  
Jing Liu ◽  
Xuan Tang ◽  
Ziran Zhai ◽  
Keming Xu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Delivery System ◽  
Peptide Conjugates ◽  
Self Assembling

A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

scholarly journals Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 858
Author(s):  
Kyriaki-Marina Lyra ◽  
Archontia Kaminari ◽  
Katerina N. Panagiotaki ◽  
Konstantinos Spyrou ◽  
Sergios Papageorgiou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Delivery System ◽  
Colloidal Stability ◽  
Triggered Release ◽  
Selective Toxicity ◽  
Molecular Transporters ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

scholarly journals Diphenylalanine Motif Drives Self‐assembling in Hybrid PNA‐peptide Conjugates

2021 ◽  
Author(s):  
Carlo Diaferia ◽  
Concetta Avitabile ◽  
Marilisa Leone ◽  
Enrico Gallo ◽  
Michele Saviano ◽  
...  
Keyword(s):  
Peptide Conjugates ◽  
Self Assembling

Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1

2015 ◽  
Vol 12 (5) ◽  
pp. 1422-1430 ◽  
Author(s):  
Masaharu Murata ◽  
Sayoko Narahara ◽  
Takahito Kawano ◽  
Nobuhito Hamano ◽  
Jing Shu Piao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pancreatic Cancer Cells ◽  
Neuropilin 1 ◽  
And Function

An Acid-Triggered Degradable and Fluorescent Nanoscale Drug Delivery System with Enhanced Cytotoxicity to Cancer Cells

2015 ◽  
Vol 16 (8) ◽  
pp. 2444-2454 ◽  
Author(s):  
Jinxia An ◽  
Xiaomei Dai ◽  
Zhongming Wu ◽  
Yu Zhao ◽  
Zhentan Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System

Novel “ruthenium cyclopentadienyl”–peptide conjugate complexes against human FGFR(+) breast cancer

2020 ◽  
Vol 49 (18) ◽  
pp. 5974-5987
Author(s):  
João Franco Machado ◽  
Miguel Machuqueiro ◽  
Fernanda Marques ◽  
M. Paula Robalo ◽  
M. Fátima M. Piedade ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Evaluation ◽  
Peptide Conjugates ◽  
Half Sandwich

Synthesis of the first half-sandwich ruthenium(ii)-cyclopentadienyl peptide conjugates and their biological evaluation against human FGFR(+) and FGFR(−) breast cancer cells.

scholarly journals Targeting EGFR Overexpression at the Surface of Colorectal Cancer Cells by Exploiting Amidated BODIPY‐Peptide Conjugates

2020 ◽  
Vol 96 (3) ◽  
pp. 581-595
Author(s):  
Tyrslai M. Williams ◽  
Zehua Zhou ◽  
Sitanshu S. Singh ◽  
Martha Sibrian‐Vazquez ◽  
Seetharama D. Jois ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Peptide Conjugates ◽  
Colorectal Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document