Self-assembling peptide-based nanodrug delivery systems

2019 ◽  
Vol 7 (12) ◽  
pp. 4888-4911 ◽  
Author(s):  
Qian Wang ◽  
Nan Jiang ◽  
Bo Fu ◽  
Fan Huang ◽  
Jianfeng Liu
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Delivery Systems ◽  
Present Review ◽  
Peptide Conjugates ◽  
Nanodrug Delivery ◽  
Self Assembling ◽  
Small Molecule Drugs ◽  
Delivery Strategies

The present review outlines the methods designing self-assembling peptide-based NDDs for small molecule drugs, with an emphasis on the different drug delivery strategies and their applications in using peptides and peptide conjugates.

Cancer Nanotechnology-An Excursion on Drug Delivery Systems

2019 ◽  
Vol 18 (15) ◽  
pp. 2078-2092 ◽  
Author(s):  
Mala Sharma ◽  
Chitranshu Pandey ◽  
Neha Sharma ◽  
Mohammad A. Kamal ◽  
Usman Sayeed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Cancer Chemoprevention ◽  
Delivery Systems ◽  
Nanostructured Lipid Carrier ◽  
Nanodrug Delivery ◽  
Drug Conjugates ◽  
Drug Nanoparticles ◽  
Cancer Nanotechnology

Background: Nanotechnology pictures a breakthrough in the domain of cancer therapy owing to its novel properties and functions. This technology is quite amendable as it allows the scientists to engineer drug nanoparticles of dimensions 10nm – 500nm permitting them to pass via leaky vasculature of tumorigenic microenvironment with higher specificity, reduced cytotoxicity and effective release without any after effects. The central part of the review zooms onto the role of nanoparticles and their targeted delivery for the cure of cancer. Methods: The novel and various versatile nanoparticle platforms viz. polymeric (drug-conjugates, micelles, dendrimers), Lipid-based (liposomes, solid nanoparticle, nanostructured lipid carrier, lipid-polymer hybrid), and stimuli-sensitive (thermoresponsive, ultrasound, pH-responsive, hydrogel) etc. have been designed for a persistent, précised nanodrug delivery and the co-delivery of collegial drug conjugates leading to the formation of safer release of myriad of drugs for cancer chemoprevention. Results: The review concerns about tracing and detailing the drug delivery systems of cancer nanotechnology. Conclusion: Nanotechnology is bestowed with the design, depiction, fabrication, and application of nanostructures, and devices with their controlled delivery together with the imaging of the selected target site and drug release at the specific site of action.

scholarly journals GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS

2017 ◽  
Vol 4 (2) ◽  
pp. 10 ◽  
Author(s):  
Harshil P. Shah ◽  
Shailesh T. Prajapati ◽  
C. N. Patel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Route ◽  
Delivery Systems ◽  
Present Review ◽  
Gastric Residence Time ◽  
In Vivo Characterization ◽  
Absorption Window

Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

scholarly journals Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1803
Author(s):  
Vivek Puri ◽  
Ameya Sharma ◽  
Pradeep Kumar ◽  
Inderbir Singh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Efficient Method ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Review Article ◽  
Present Review ◽  
Tabular Form ◽  
Thiolated Polymers ◽  
Drug Delivery Applications

Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.

scholarly journals Extracellular Vesicles as Natural Nanosized Delivery Systems for Small-Molecule Drugs and Genetic Material: Steps towards the Future Nanomedicines

2015 ◽  
Vol 18 (3) ◽  
pp. 396 ◽  
Author(s):  
Mustafa Kotmakçı ◽  
Vildan Bozok Çetintaş
Keyword(s):  
Extracellular Vesicles ◽  
Small Molecule ◽  
Protein Delivery ◽  
Drug Loading ◽  
Genetic Material ◽  
Delivery Systems ◽  
Small Molecule Drugs ◽  
The Common ◽  
Therapeutic Protocols ◽  
Targeting Ability

A new platform for drug, gene and peptide-protein delivery is emerging, under the common name of “extracellular vesicles”. Extracellular vesicles (EVs) are 30-1000 nm-sized cell-derived, liposome-like vesicles. Current research on EVs as nano-delivery systems for small-molecule drugs and genetic material, reveal that these tiny, biologically-derived vesicles carry a great potential to boost the efficacy of many therapeutic protocols. Several features of EVs; from efficacy to safety, from passive to active targeting ability, the opportunity to be biologically or chemically labelled, and most importantly, their eobiotic origin make them promising candidate for development of the next generation personalized nanomedicines. The aim of this article is to provide a view on the current research in which EVs are used as drug/genetic material delivery systems. Their application areas, drug loading and targeting strategies, and biodistribution properties are discussed.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Matrix metalloproteinase-sensitive hydrogel microparticles for pulmonary drug delivery of small molecule drugs or proteins

2015 ◽  
Vol 3 (27) ◽  
pp. 5629-5634 ◽  
Author(s):  
Emilie Secret ◽  
Kelsey E. Crannell ◽  
Stefan J. Kelly ◽  
Maria Villancio-Wolter ◽  
Jennifer S. Andrew
Keyword(s):  
Drug Delivery ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Small Molecule ◽  
Pulmonary Drug Delivery ◽  
Hydrogel Microparticles ◽  
Small Molecule Drugs

Hydrogel microparticles sensitive to matrix metalloproteinases are studied for release of drugs and proteins into the lungs.

scholarly journals Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Polymers ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 779-811 ◽  
Author(s):  
Giulia Bonacucina ◽  
Marco Cespi ◽  
Giovanna Mencarelli ◽  
Gianfabio Giorgioni ◽  
Giovanni Filippo Palmieri
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling

Engineered Polymer–Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems

2017 ◽  
Vol 18 (5) ◽  
pp. 1532-1543 ◽  
Author(s):  
Hiteshri Makwana ◽  
Francesca Mastrotto ◽  
Johannes P. Magnusson ◽  
Darrell Sleep ◽  
Joanna Hay ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems
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