Co-assembled supramolecular hydrogels of doxorubicin and indomethacin-derived peptide conjugates for synergistic inhibition of cancer cell growth

2019 ◽  
Vol 55 (30) ◽  
pp. 4411-4414 ◽  
Author(s):  
Leixia Mei ◽  
Suyun He ◽  
Ziqi Liu ◽  
Keming Xu ◽  
Wenying Zhong
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Peptide Conjugates ◽  
Synergistic Inhibition ◽  
Self Assembling

Co-assembly of doxorubicin and a NSAID-based self-assembling peptide conjugate promotes synergistic inhibition of cancer cell growth.

scholarly journals Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2061
Author(s):  
Cecilia Pozzi ◽  
Matteo Santucci ◽  
Gaetano Marverti ◽  
Domenico D’Arca ◽  
Lorenzo Tagliazucchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Thymidylate Synthase ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cells ◽  
Preclinical Research ◽  
Cancer Cell Growth ◽  
X Ray ◽  
Synergistic Inhibition

Combining drugs represent an approach to efficiently prevent and overcome drug resistance and to reduce toxicity; yet it is a highly challenging task, particularly if combinations of inhibitors of the same enzyme target are considered. To show that crystallographic and inhibition kinetic information can provide indicators of cancer cell growth inhibition by combinations of two anti-human thymidylate synthase (hTS) drugs, we obtained the X-ray crystal structure of the hTS:raltitrexed:5-fluorodeoxyuridine monophosphate (FdUMP) complex. Its analysis showed a ternary complex with both molecules strongly bound inside the enzyme catalytic cavity. The synergistic inhibition of hTS and its mechanistic rationale were consistent with the structural analysis. When administered in combination to A2780 and A2780/CP ovarian cancer cells, the two drugs inhibited ovarian cancer cell growth additively/synergistically. Together, these results support the idea that X-ray crystallography can provide structural indicators for designing combinations of hTS (or any other target)-directed drugs to accelerate preclinical research for therapeutic application.

Role of gene regulation in the anticancer activity of carotenoids

2002 ◽  
Vol 74 (8) ◽  
pp. 1469-1477 ◽  
Author(s):  
Yoav Sharoni ◽  
Michael Danilenko ◽  
Shlomo Walfisch ◽  
Hadar Amir ◽  
Amit Nahum ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Fruits And Vegetables ◽  
Cancer Cell Proliferation ◽  
Inhibitory Effects ◽  
Cancer Cell Growth ◽  
Cyclin Dependent Kinases ◽  
Synergistic Inhibition ◽  
Powerful Means

There is extensive evidence that high intake of fruits and vegetables is associated with decreased risk of many types of cancers. Thus, it is widely accepted that diet changes are a powerful means to prevent cancer. Although there is a growing interest in the role of the tomato carotenoid lycopene in cancer prevention and treatment, we hypothesize that a single micronutrient cannot replace the power of the concerted action of multiple agents derived from a diet rich in fruits and vegetables. Indeed, we found that lycopene can synergize with other phytonutrients in the inhibition of cancer cell growth. The mechanism underlying the inhibitory effects of lycopene and other carotenoids involves interference in several pathways related to cancer cell proliferation and includes changes in the expression of many proteins participating in these processes, such as connexins, cyclins, cyclin-dependent kinases, and their inhibitors. These changes in protein expression suggest that the initial effect involves modulation of transcription by ligand-activated nuclear receptors or by other transcription factors. It is feasible to suggest that carotenoids and their oxidized derivatives interact with a network of transcription systems that are activated by different ligands at low affinity and specificity and that this activation leads to the synergistic inhibition of cell growth.

scholarly journals Synergistic Inhibition of Lung Cancer Cell Growth by Nobiletin and Atorvastatin in Combination

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Noppawat Charoensinphon ◽  
Jinkai Zheng ◽  
Peiju Qiu ◽  
Perline Ngauv ◽  
Hang Xiao
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Synergistic Inhibition

scholarly journals Synergistic Inhibition of Lung Cancer Cell Growth by Tangeretin and Atorvastatin

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Noppawat Charoensinphon ◽  
Peiju Qiu ◽  
Ping Dong ◽  
Jinkai Zheng ◽  
Pearline Ngauv ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Synergistic Inhibition

scholarly journals Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

2013 ◽  
Vol 49 (18) ◽  
pp. 3936-3944 ◽  
Author(s):  
Karen E. Sheppard ◽  
Carleen Cullinane ◽  
Katherine M. Hannan ◽  
Meaghan Wall ◽  
Joanna Chan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Erk Pathway ◽  
Cancer Cell Growth ◽  
Synergistic Inhibition

Supramolecular nanofibers of self-assembling peptides and DDP to inhibit cancer cell growth

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 56903-56906 ◽  
Author(s):  
Xiaoli Zhang ◽  
Can Li ◽  
Youzhi Wang ◽  
Caiwen Ou ◽  
Shenglu Ji ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Peptide Amphiphile ◽  
Self Assembling

The addition of cis-dichlorodiamineplatinum(ii) to a taxol-peptide amphiphile results in hydrogelations.

Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth

2019 ◽  
Vol 63 ◽  
pp. 109381 ◽  
Author(s):  
Xuanhao Li ◽  
Shanshan He ◽  
Ye Tian ◽  
Robert M. Weiss ◽  
Darryl T. Martin
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Erk Signaling ◽  
Cancer Cell Growth ◽  
Synergistic Inhibition
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