scholarly journals pH-Dependent Anticancer Drug Release from Silk Nanoparticles

2013 ◽  
Vol 2 (12) ◽  
pp. 1606-1611 ◽  
Author(s):  
F. Philipp Seib ◽  
Gregory T. Jones ◽  
Jelena Rnjak-Kovacina ◽  
Yinan Lin ◽  
David L. Kaplan
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Ph Dependent

Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity

Nanoscale ◽  
2012 ◽  
Vol 4 (18) ◽  
pp. 5744 ◽  
Author(s):  
Xiao-Ming Zhu ◽  
Jing Yuan ◽  
Ken Cham-Fai Leung ◽  
Siu-Fung Lee ◽  
Kathy W. Y. Sham ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Superparamagnetic Iron Oxide ◽  
Ph Dependent

scholarly journals In situ protein-templated porous protein–hydroxylapatite nanocomposite microspheres for pH-dependent sustained anticancer drug release

2017 ◽  
Vol 5 (21) ◽  
pp. 3945-3954 ◽  
Author(s):  
Yajun Shuai ◽  
Shuxu Yang ◽  
Chenlin Li ◽  
Liangjun Zhu ◽  
Chuanbin Mao ◽  
...  
Keyword(s):  
Drug Release ◽  
Porous Structure ◽  
Anticancer Drug ◽  
Release Profile ◽  
Drug Release Profile ◽  
P Protein ◽  
Ph Dependent ◽  
Sbf Solution

Protein–hydroxylapatite microspheres with a porous structure and a pH-dependent drug release profile are fabricated by incubating sericin in 1.5 SBF solution.

scholarly journals Anticancer Drug Release System Based on Hollow Silica Nanocarriers Triggered by Tumor Cellular Microenvironments

ACS Omega ◽  
2020 ◽  
Author(s):  
Shaoxin Deng ◽  
Cheng-Xing Cui ◽  
Lingyao Duan ◽  
Linfeng Hu ◽  
Xiaoxun Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Hollow Silica ◽  
Release System ◽  
Drug Release System ◽  
Cellular Microenvironments

scholarly journals A novel microwave stimulus remote-controlled anticancer drug release system based on Janus TiO2-&mSiO2 nanocarriers

2021 ◽  
Vol 123 ◽  
pp. 111968
Author(s):  
Ye Liu ◽  
Yangying Si ◽  
Mingyu Di ◽  
Dejian Tang ◽  
Li Meng ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Release System ◽  
Drug Release System

Enhanced Analytic Approach for Describing pH Triggered Fast Drug Release Systems

2021 ◽  
Vol 18 ◽  
Author(s):  
Aykut Elmas ◽  
Guliz Akyuz ◽  
Ayhan Bergal ◽  
Muberra Andac ◽  
Omer Andac
Keyword(s):  
Drug Release ◽  
Ph Dependence ◽  
Slope Angle ◽  
Ph Sensitive ◽  
Analytic Model ◽  
Two Dimensional ◽  
Analytic Equation ◽  
One Dimensional ◽  
Ph Dependent ◽  
Fast Release

Background: pH sensitive dendrimers attached to nanocarriers, as one of the drug release systems, has become quite popular due to their ease of manufacture in experimental conditions and ability to generate fast drug release in the targeted area. This kind of fast release behavior cannot be represented properly most of the existing kinetic mathematical models. Besides, these models have either no pH dependence or pH dependence added separately. So, they have remained one dimensional. Objective: The aim of this study was to establish the proper analytic equation to describe the fast release of drugs from pH sensitive nanocarrier systems. Then, to combine it with the pH dependent equation for establishing a two-dimensional model for whole system. Methods: We used four common kinetic models for comparison and we fitted them to the release data. Finding that, only Higuchi and Korsmeyer-Peppas models show acceptable fit results. None of these models have pH dependence. To get a better description for pH triggered fast release, we observed the behavior of the slope angle of the release curve. Then we puroposed a new analytic equation by using relation between the slope angle and time. Result: To add a pH dependent equation, we assumed the drug release is “on” or “off” above/below specific pH value and we modified a step function to get a desired behavior. Conclusion: Our new analytic model shows good fitting, not only one-dimensional time dependent release, but also two-dimensional pH dependent release, that provides a useful analytic model to represent release profiles of pH sensitive fast drug release systems.

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

Smart pH/Redox Dual-Responsive Nanogels for On-Demand Intracellular Anticancer Drug Release

2016 ◽  
Vol 8 (12) ◽  
pp. 7729-7738 ◽  
Author(s):  
Hao Yang ◽  
Qin Wang ◽  
Shan Huang ◽  
Ai Xiao ◽  
Fuying Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
On Demand ◽  
Dual Responsive
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