Thermal and Photo Dual-Responsive Core–Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release

2019 ◽  
Vol 123 (16) ◽  
pp. 10658-10665 ◽  
Author(s):  
Xiaotao Wang ◽  
Chuang Liu ◽  
Zhenhua Li ◽  
Chak-Yin Tang ◽  
Wing-Cheung Law ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Upconversion Nanoparticles ◽  
Core Shell ◽  
Polymeric Nanocarriers ◽  
Dual Responsive

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

Smart pH/Redox Dual-Responsive Nanogels for On-Demand Intracellular Anticancer Drug Release

2016 ◽  
Vol 8 (12) ◽  
pp. 7729-7738 ◽  
Author(s):  
Hao Yang ◽  
Qin Wang ◽  
Shan Huang ◽  
Ai Xiao ◽  
Fuying Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
On Demand ◽  
Dual Responsive

Targeted Drug Delivery of Teniposide by Magnetic Nanocarrier

2020 ◽  
Vol 16 (4) ◽  
pp. 608-616
Author(s):  
Saeed Kakaei ◽  
Elham Sattarzadeh Khameneh ◽  
Effat Ghasemi ◽  
Mustafa Aghazadeh
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Drug Release ◽  
Anticancer Drug ◽  
Amide Bond ◽  
Cancer Drug ◽  
Core Shell ◽  
Magnetic Stimulus ◽  
Systemic Spread ◽  
Ester Formation

Background:: Drug delivery technologies adjust drug release profile, absorption, distribution, and elimination for benefiting to the improvement of product efficacy, effectiveness, and safety. The IONPs release drugs via enzymatic activity, changes in physiological conditions such as pH, osmolality radiation, or temperature. In the case of nanoparticles that respond to the magnetic stimulus, the drug directs its action towards the site of a detected magnetic field. Objective:: In this study, the synthesis of a specific drug-delivery system based on magnetic nanocarrier for teniposide as an anticancer drug is reported. The iron oxide@SiO2 core-shell nanoparticles were functionalized with APTS as a spacer then coupling to the DOTA molecules. Anticancer drug of teniposide conjugated to the acidic group of DOTA via an amide bond. Multi-purpose magnetic nanoparticles were synthesized for targeted delivery of teniposide. Methods: Iron oxide nanoparticles were firstly coated with silica and their surface was then modified with aminopropyltriethoxysilane (APTES) through an in situ method. DOTA-NHS was also coupled to Fe3O4@SiO2-APTES via an amide bond formation. In the final step, teniposide as an anti-cancer drug was conjugated with DOTA through ester bonds, and the final compound of Fe3O4@SiO2- APTES-DOTA-Teniposide was obtained. The obtained nanocarrier was evaluated by various analyses. Results:: The multifunctional Fe3O4@SiO2-APTES-DOTA nanocarriers were successfully synthesized and characterized by XRD, FTIR, TGA, and UV-vis techniques. The silica-coated magnetic nanoparticle functionalized with aminopropyl triethoxysilane (APTES) was reacted with an acid group of DOTA, and teniposide was then coupled to DOTA through ester formation bonds. Drug release experiments showed that most of the conjugated teniposide were released within the first 12h. Conclusion:: The fabricated nano-carriers exhibited pH-sensitive drug release behavior, which can minimize the non-specific systemic spread of toxic drugs during circulation whilst maximizing the efficiency of tumor-targeted anticancer drug delivery for this purpose. The prepared teniposidegrafted Fe3O4@SiO2-APTES-DOTA core–shell structure nanoparticles showed a magnetic property with exposure to magnetic fields, indicating a great potential application in the treatment of cancer using magnetic targeting drug-delivery technology and multimodal imaging techniques.

Core/Shell Dual‐Responsive Nanocarriers via Iron‐Mineralized Electrostatic Self‐Assembly for Precise Pesticide Delivery

2021 ◽  
pp. 2102027
Author(s):  
Da‐xia Zhang ◽  
Jiang Du ◽  
Rui Wang ◽  
Jian Luo ◽  
Tong‐fang Jing ◽  
...  
Keyword(s):  
Self Assembly ◽  
Core Shell ◽  
Dual Responsive

scholarly journals Anticancer Drug Release System Based on Hollow Silica Nanocarriers Triggered by Tumor Cellular Microenvironments

ACS Omega ◽  
2020 ◽  
Author(s):  
Shaoxin Deng ◽  
Cheng-Xing Cui ◽  
Lingyao Duan ◽  
Linfeng Hu ◽  
Xiaoxun Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Hollow Silica ◽  
Release System ◽  
Drug Release System ◽  
Cellular Microenvironments
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