Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity

Nanoscale ◽  
2012 ◽  
Vol 4 (18) ◽  
pp. 5744 ◽  
Author(s):  
Xiao-Ming Zhu ◽  
Jing Yuan ◽  
Ken Cham-Fai Leung ◽  
Siu-Fung Lee ◽  
Kathy W. Y. Sham ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Superparamagnetic Iron Oxide ◽  
Ph Dependent

scholarly journals Superparamagnetic Iron Oxide Nanotheranostics for Targeted Cancer Cell Imaging and pH-Dependent Intracellular Drug Release

2010 ◽  
Vol 7 (6) ◽  
pp. 1974-1984 ◽  
Author(s):  
Peng Zou ◽  
Yanke Yu ◽  
Y. Andrew Wang ◽  
Yanqiang Zhong ◽  
Amanda Welton ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Cancer Cell ◽  
Cell Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Cancer Cell Imaging ◽  
Ph Dependent

scholarly journals Real-Time Monitoring of Anticancer Drug Release with Highly Fluorescent Star-Conjugated Copolymer as a Drug Carrier

2014 ◽  
Vol 15 (4) ◽  
pp. 1355-1364 ◽  
Author(s):  
Feng Qiu ◽  
Dali Wang ◽  
Qi Zhu ◽  
Lijuan Zhu ◽  
Gangsheng Tong ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Real Time Monitoring ◽  
Conjugated Copolymer

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

Targeted Drug Delivery of Teniposide by Magnetic Nanocarrier

2020 ◽  
Vol 16 (4) ◽  
pp. 608-616
Author(s):  
Saeed Kakaei ◽  
Elham Sattarzadeh Khameneh ◽  
Effat Ghasemi ◽  
Mustafa Aghazadeh
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Drug Release ◽  
Anticancer Drug ◽  
Amide Bond ◽  
Cancer Drug ◽  
Core Shell ◽  
Magnetic Stimulus ◽  
Systemic Spread ◽  
Ester Formation

Background:: Drug delivery technologies adjust drug release profile, absorption, distribution, and elimination for benefiting to the improvement of product efficacy, effectiveness, and safety. The IONPs release drugs via enzymatic activity, changes in physiological conditions such as pH, osmolality radiation, or temperature. In the case of nanoparticles that respond to the magnetic stimulus, the drug directs its action towards the site of a detected magnetic field. Objective:: In this study, the synthesis of a specific drug-delivery system based on magnetic nanocarrier for teniposide as an anticancer drug is reported. The iron oxide@SiO2 core-shell nanoparticles were functionalized with APTS as a spacer then coupling to the DOTA molecules. Anticancer drug of teniposide conjugated to the acidic group of DOTA via an amide bond. Multi-purpose magnetic nanoparticles were synthesized for targeted delivery of teniposide. Methods: Iron oxide nanoparticles were firstly coated with silica and their surface was then modified with aminopropyltriethoxysilane (APTES) through an in situ method. DOTA-NHS was also coupled to Fe3O4@SiO2-APTES via an amide bond formation. In the final step, teniposide as an anti-cancer drug was conjugated with DOTA through ester bonds, and the final compound of Fe3O4@SiO2- APTES-DOTA-Teniposide was obtained. The obtained nanocarrier was evaluated by various analyses. Results:: The multifunctional Fe3O4@SiO2-APTES-DOTA nanocarriers were successfully synthesized and characterized by XRD, FTIR, TGA, and UV-vis techniques. The silica-coated magnetic nanoparticle functionalized with aminopropyl triethoxysilane (APTES) was reacted with an acid group of DOTA, and teniposide was then coupled to DOTA through ester formation bonds. Drug release experiments showed that most of the conjugated teniposide were released within the first 12h. Conclusion:: The fabricated nano-carriers exhibited pH-sensitive drug release behavior, which can minimize the non-specific systemic spread of toxic drugs during circulation whilst maximizing the efficiency of tumor-targeted anticancer drug delivery for this purpose. The prepared teniposidegrafted Fe3O4@SiO2-APTES-DOTA core–shell structure nanoparticles showed a magnetic property with exposure to magnetic fields, indicating a great potential application in the treatment of cancer using magnetic targeting drug-delivery technology and multimodal imaging techniques.

scholarly journals pH-Dependent Anticancer Drug Release from Silk Nanoparticles

2013 ◽  
Vol 2 (12) ◽  
pp. 1606-1611 ◽  
Author(s):  
F. Philipp Seib ◽  
Gregory T. Jones ◽  
Jelena Rnjak-Kovacina ◽  
Yinan Lin ◽  
David L. Kaplan
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Ph Dependent
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