Flower‐Like Nanozymes with Large Accessibility of Single Atom Catalysis Sites for ROS Generation Boosted Tumor Therapy

2021 ◽  
pp. 2111171
Author(s):  
Yuxin Xing ◽  
Lu Wang ◽  
Liucan Wang ◽  
Jixi Huang ◽  
Shuai Wang ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Single Atom ◽  
Ros Generation

scholarly journals Tumor Therapy: Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies (Adv. Mater. 29/2021)

2021 ◽  
Vol 33 (29) ◽  
pp. 2170227
Author(s):  
Fangxue Du ◽  
Luchang Liu ◽  
Zihe Wu ◽  
Zhenyang Zhao ◽  
Wei Geng ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Single Atom

scholarly journals Mitochondria-acting carrier-free nanoplatform self-assembled by α-tocopheryl succinate carrying cisplatin for combinational tumor therapy

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Heng Mei ◽  
Jing Li ◽  
Shengsheng Cai ◽  
Xuequan Zhang ◽  
Wenqiang Shi ◽  
...  
Keyword(s):  
Drug Loading ◽  
Tumor Therapy ◽  
Ros Generation ◽  
Drug Conjugates ◽  
Tocopheryl Succinate ◽  
Carrier Free ◽  
Negative Surface ◽  
Inert Carrier ◽  
Self Assembled

Abstract Unsatisfactory drug loading capability, potential toxicity of the inert carrier and the limited therapeutic effect of a single chemotherapy drug are all vital inhibitory factors of carrier-assisted drug delivery systems for chemotherapy. To address the above obstacles, a series of carrier-free nanoplatforms self-assembled by dual-drug conjugates was constructed to reinforce chemotherapy against tumors by simultaneously disrupting intratumoral DNA activity and inhibiting mitochondria function. In this nanoplatform, the mitochondria-targeting small-molecular drug, α-tocopheryl succinate (TOS), firstly self-assembled into nanoparticles, which then were used as the carrier to conjugate cisplatin (CDDP). Systematic characterization results showed that this nanoplatform exhibited suitable particle size and a negative surface charge with good stability in physicochemical environments, as well as pH-sensitive drug release and efficient cellular uptake. Due to the combined effects of reactive oxygen species (ROS) generation by TOS and DNA damage by CDDP, the developed nanoplatform could induce mitochondrial dysfunction and elevated cell apoptosis, resulting in highly efficient anti-tumor outcomes in vitro. Collectively, the combined design principles adopted for carrier-free nanodrugs construction in this study aimed at targeting different intracellular organelles for facilitating ROS production and DNA disruption can be extended to other carrier-free nanodrugs-dependent therapeutic systems.

A metal–semiconductor nanocomposite as an efficient oxygen-independent photosensitizer for photodynamic tumor therapy

2017 ◽  
Vol 2 (6) ◽  
pp. 349-355 ◽  
Author(s):  
Jin-Xuan Fan ◽  
Miao-Deng Liu ◽  
Chu-Xin Li ◽  
Sheng Hong ◽  
Di-Wei Zheng ◽  
...  
Keyword(s):  
Water Splitting ◽  
Tumor Therapy ◽  
Ros Generation ◽  
Cds Nanorods ◽  
Semiconductor Nanocomposite

Metal (Au) deposition on CdSe-seeded/CdS nanorods significantly improves the efficiency of water splitting for ROS generation without oxygen participation, and the composites were further applied as an oxygen-independent photosensitizer for tumor PDT treatment.

A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

2021 ◽  
Vol 9 (39) ◽  
pp. 8253-8262
Author(s):  
Yali Chen ◽  
Yujun Cai ◽  
Xingsu Yu ◽  
Hong Xiao ◽  
Haozhe He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

Nanocatalytic Tumor Therapy by Single-Atom Catalysts

ACS Nano ◽  
2019 ◽  
Author(s):  
Minfeng Huo ◽  
Liying Wang ◽  
Youwei Wang ◽  
Yu Chen ◽  
Jianlin Shi
Keyword(s):  
Tumor Therapy ◽  
Single Atom

Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

2021 ◽  
Author(s):  
Yang Zhu ◽  
Wenyu Wang ◽  
Junjie Cheng ◽  
Chao Zhao ◽  
Yi Dai ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Cascade Reactions ◽  
Single Atom ◽  
Stimuli Responsive

Single‐Atom Catalysts for Nanocatalytic Tumor Therapy

Small ◽  
2021 ◽  
pp. 2004467
Author(s):  
Xiangyu Lu ◽  
Shanshan Gao ◽  
Han Lin ◽  
Jianlin Shi
Keyword(s):  
Tumor Therapy ◽  
Single Atom

scholarly journals Evaluation of Graphene Oxide Induced Cellular Toxicity and Transcriptome Analysis in Human Embryonic Kidney Cells

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 969 ◽  
Author(s):  
Sangiliyandi Gurunathan ◽  
Muhammad Arsalan Iqbal ◽  
Muhammad Qasim ◽  
Chan Hyeok Park ◽  
Hyunjin Yoo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Molecular Mechanisms ◽  
Cellular Responses ◽  
Hek293 Cells ◽  
Single Atom ◽  
Ros Generation ◽  
Human Embryonic Kidney ◽  
Human Embryonic Kidney Cells ◽  
In Vitro Investigation

Graphene, a two-dimensional carbon sheet with single-atom thickness, shows immense promise in several nanoscientific and nanotechnological applications, including in sensors, catalysis, and biomedicine. Although several studies have shown the cytotoxicity of graphene oxide in different cell types, there are no comprehensive studies on human embryonic kidney (HEK293) cells that include transcriptomic analysis and an in vitro investigation into the mechanisms of cytotoxicity following exposure to graphene oxide. Therefore, we exposed HEK293 cells to different concentrations of graphene oxide for 24 h and performed several cellular assays. Cell viability and proliferation assays revealed a significant dose-dependent cytotoxic effect on HEK293 cells. Cytotoxicity assays showed increased lactate dehydrogenase (LDH) leakage and reactive oxygen species (ROS) generation, and decreased levels of reduced glutathione (GSH) and increased level of oxidized glutathione indicative of oxidative stress. This detailed mechanistic approach showed that graphene oxide exposure elicits significant decreases in mitochondrial membrane potential and ATP synthesis, as well as in DNA damage and caspase 3 activity. Furthermore, our RNA-Seq analysis revealed that HEK293 cells exposed to graphene oxide significantly altered the expression of genes involved in multiple apoptosis-related biological pathways. Moreover, graphene oxide exposure perturbed the expression of key transcription factors, promoting these apoptosis-related pathways by regulating their downstream genes. Our analysis provides mechanistic insights into how exposure to graphene oxide induces changes in cellular responses and massive cell death in HEK293 cells. To our knowledge, this is the first study describing a combination of cellular responses and transcriptome in HEK293 cells exposed to graphene oxide nanoparticles, providing a foundation for understanding the molecular mechanisms of graphene oxide-induced cytotoxicity and for the development of new therapeutic strategies.

Single Atom Image Contrast in Fixed Beam Dark Field Electron Microscopy

1974 ◽  
Vol 32 ◽  
pp. 366-367
Author(s):  
Wah Chi
Keyword(s):  
Scattering Amplitude ◽  
Present Report ◽  
Dark Field ◽  
Image Contrast ◽  
Single Atom ◽  
Optical Theorem ◽  
Hartree Fock ◽  
Heavy Atoms ◽  
Beam Stop ◽  
Fixed Beam

Resolution and contrast are the important factors to determine the feasibility of imaging single heavy atoms on a thin substrate in an electron microscope. The present report compares the atom image characteristics in different modes of fixed beam dark field microscopy including the ideal beam stop (IBS), a wire beam stop (WBS), tilted illumination (Tl) and a displaced aperture (DA). Image contrast between one Hg and a column of linearly aligned carbon atoms (representing the substrate), are also discussed. The assumptions in the present calculations are perfectly coherent illumination, atom object is represented by spherically symmetric potential derived from Relativistic Hartree Fock Slater wave functions, phase grating approximation is used to evaluate the complex scattering amplitude, inelastic scattering is ignored, phase distortion is solely due to defocus and spherical abberation, and total elastic scattering cross section is evaluated by the Optical Theorem. The atom image intensities are presented in a Z-modulation display, and the details of calculation are described elsewhere.

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