Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

2021 ◽  
Author(s):  
Yang Zhu ◽  
Wenyu Wang ◽  
Junjie Cheng ◽  
Chao Zhao ◽  
Yi Dai ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Cascade Reactions ◽  
Single Atom ◽  
Stimuli Responsive

scholarly journals Tumor Therapy: Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies (Adv. Mater. 29/2021)

2021 ◽  
Vol 33 (29) ◽  
pp. 2170227
Author(s):  
Fangxue Du ◽  
Luchang Liu ◽  
Zihe Wu ◽  
Zhenyang Zhao ◽  
Wei Geng ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Single Atom

Flower‐Like Nanozymes with Large Accessibility of Single Atom Catalysis Sites for ROS Generation Boosted Tumor Therapy

2021 ◽  
pp. 2111171
Author(s):  
Yuxin Xing ◽  
Lu Wang ◽  
Liucan Wang ◽  
Jixi Huang ◽  
Shuai Wang ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Single Atom ◽  
Ros Generation

MiRNA Delivery System Based on Stimuli-Responsive Gold Nanoparticle Aggregates for Multimodal Tumor Therapy

2019 ◽  
Vol 2 (7) ◽  
pp. 2833-2839 ◽  
Author(s):  
Xiangdong Wang ◽  
Nuo Jin ◽  
Qiao Wang ◽  
Tao Liu ◽  
Kangcan Liu ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Delivery System ◽  
Tumor Therapy ◽  
Stimuli Responsive ◽  
Nanoparticle Aggregates

Nanocatalytic Tumor Therapy by Single-Atom Catalysts

ACS Nano ◽  
2019 ◽  
Author(s):  
Minfeng Huo ◽  
Liying Wang ◽  
Youwei Wang ◽  
Yu Chen ◽  
Jianlin Shi
Keyword(s):  
Tumor Therapy ◽  
Single Atom

Endowing Nanozymes High Biocatalytic Selectivity by Substrates Channeling and Screening

2020 ◽  
Author(s):  
Qing Zhou ◽  
Hong Yang ◽  
Xinghua Chen ◽  
Yuan Xu ◽  
Dan Han ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Disease Diagnosis ◽  
Cascade Reactions ◽  
Substrate Selectivity ◽  
Confined Space ◽  
Early Disease ◽  
Nitrogen Doped ◽  
The Poor ◽  
Prussian Blue Nanoparticles ◽  
Nitrogen Doped Carbon

As an alternative to surmount the weakness of natural enzymes, nanozymes have recently attracted extensive attention from early disease diagnosis to tumor therapy. However, due to the lack of enzyme-like molecular recognition units, the poor substrate selectivity of nanozyme-catalyzed reaction significantly restricts their widespread applications. By biomimicking the ingenuity of metabolism process in living, herein we report a multiple-nanozymes system capable of improving the substrate selectivity via cascade reactions in a confined space. As a showcase, the nitrogen-doped carbon nanocages (NCNC) and Prussian blue nanoparticles (PB NPs) were successfully coupled in a microfluidic device to highly selective oxidation and detection of ascorbic acid (AA, an important electron donor and catalyst for alleviation of oxidative stress) against other interferences. It was revealed that the products of the prior nanozymatic reaction were effectively <a></a><a>screened</a> as the reactants of the next one, thus stepwise improving the overall selectivity of the all-nanozyme system. This work may open a new door to improve the selectivity of all-nanozyme-system for prospect applications.

A tumor-targeted nanoplatform with stimuli-responsive cascaded activities for multiple model tumor therapy

2020 ◽  
Vol 8 (7) ◽  
pp. 1865-1874 ◽  
Author(s):  
Ronghua Jin ◽  
Jirong Xie ◽  
Xiaoshan Yang ◽  
Yu Tian ◽  
Pingyun Yuan ◽  
...  
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Drug Efflux ◽  
Multiple Model ◽  
Stimuli Responsive ◽  
Tumor Treatment ◽  
Model Tumor

A rambutan-like nanocomplex was designed to achieve low-drug-efflux chemotherapy and low-temperature photothermal therapy for effective and accurate tumor treatment.

Poly(N-isopropylacrylamide) derived nanogels demonstrated thermosensitive self-assembly and GSH-triggered drug release for efficient tumor Therapy

2019 ◽  
Vol 10 (29) ◽  
pp. 4031-4041 ◽  
Author(s):  
Jiaojiao Chen ◽  
Ming Wu ◽  
Hanitrarimalala Veroniaina ◽  
Subhankar Mukhopadhyay ◽  
Juequan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Triggered Drug Release

Recently, interest in stimuli-responsive core–shell nanogels as drug delivery systems for tumor therapy has increased.

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