A metal–semiconductor nanocomposite as an efficient oxygen-independent photosensitizer for photodynamic tumor therapy

2017 ◽  
Vol 2 (6) ◽  
pp. 349-355 ◽  
Author(s):  
Jin-Xuan Fan ◽  
Miao-Deng Liu ◽  
Chu-Xin Li ◽  
Sheng Hong ◽  
Di-Wei Zheng ◽  
...  
Keyword(s):  
Water Splitting ◽  
Tumor Therapy ◽  
Ros Generation ◽  
Cds Nanorods ◽  
Semiconductor Nanocomposite

Metal (Au) deposition on CdSe-seeded/CdS nanorods significantly improves the efficiency of water splitting for ROS generation without oxygen participation, and the composites were further applied as an oxygen-independent photosensitizer for tumor PDT treatment.

scholarly journals Mitochondria-acting carrier-free nanoplatform self-assembled by α-tocopheryl succinate carrying cisplatin for combinational tumor therapy

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Heng Mei ◽  
Jing Li ◽  
Shengsheng Cai ◽  
Xuequan Zhang ◽  
Wenqiang Shi ◽  
...  
Keyword(s):  
Drug Loading ◽  
Tumor Therapy ◽  
Ros Generation ◽  
Drug Conjugates ◽  
Tocopheryl Succinate ◽  
Carrier Free ◽  
Negative Surface ◽  
Inert Carrier ◽  
Self Assembled

Abstract Unsatisfactory drug loading capability, potential toxicity of the inert carrier and the limited therapeutic effect of a single chemotherapy drug are all vital inhibitory factors of carrier-assisted drug delivery systems for chemotherapy. To address the above obstacles, a series of carrier-free nanoplatforms self-assembled by dual-drug conjugates was constructed to reinforce chemotherapy against tumors by simultaneously disrupting intratumoral DNA activity and inhibiting mitochondria function. In this nanoplatform, the mitochondria-targeting small-molecular drug, α-tocopheryl succinate (TOS), firstly self-assembled into nanoparticles, which then were used as the carrier to conjugate cisplatin (CDDP). Systematic characterization results showed that this nanoplatform exhibited suitable particle size and a negative surface charge with good stability in physicochemical environments, as well as pH-sensitive drug release and efficient cellular uptake. Due to the combined effects of reactive oxygen species (ROS) generation by TOS and DNA damage by CDDP, the developed nanoplatform could induce mitochondrial dysfunction and elevated cell apoptosis, resulting in highly efficient anti-tumor outcomes in vitro. Collectively, the combined design principles adopted for carrier-free nanodrugs construction in this study aimed at targeting different intracellular organelles for facilitating ROS production and DNA disruption can be extended to other carrier-free nanodrugs-dependent therapeutic systems.

All-in-one visible-light-driven water splitting by combining nanoparticulate and molecular co-catalysts on CdS nanorods

Nature Energy ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 862-869 ◽  
Author(s):  
Christian M. Wolff ◽  
Peter D. Frischmann ◽  
Marcus Schulze ◽  
Bernhard J. Bohn ◽  
Robin Wein ◽  
...  
Keyword(s):  
Visible Light ◽  
Water Splitting ◽  
Co Catalysts ◽  
Cds Nanorods ◽  
Visible Light Driven

A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy

2021 ◽  
Vol 9 (39) ◽  
pp. 8253-8262
Author(s):  
Yali Chen ◽  
Yujun Cai ◽  
Xingsu Yu ◽  
Hong Xiao ◽  
Haozhe He ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Therapy Strategies

Reactive oxygen species (ROS) mediated tumor therapy strategies have exhibited great prospects and attracted increasing attention, among which photodynamic therapy (PDT) has been well-established.

Flower‐Like Nanozymes with Large Accessibility of Single Atom Catalysis Sites for ROS Generation Boosted Tumor Therapy

2021 ◽  
pp. 2111171
Author(s):  
Yuxin Xing ◽  
Lu Wang ◽  
Liucan Wang ◽  
Jixi Huang ◽  
Shuai Wang ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Single Atom ◽  
Ros Generation

Small molecular amine mediated synthesis of hydrophilic CdS nanorods and their photoelectrochemical water splitting performance

2015 ◽  
Vol 44 (3) ◽  
pp. 1465-1472 ◽  
Author(s):  
Chunlin Bao ◽  
Guoxing Zhu ◽  
Jing Yang ◽  
Miaomiao Liu ◽  
Rongxian Zhang ◽  
...  
Keyword(s):  
Water Splitting ◽  
Elemental Sulfur ◽  
Photoelectrochemical Water Splitting ◽  
Photoelectrochemical Properties ◽  
High Quality ◽  
Cds Nanocrystals ◽  
Cds Nanorods

Small molecular amine was selected as the activation agent for elemental sulfur and as a mediator for the formation of hydrophilic CdS nanocrystals with high quality, which exhibit efficient photoelectrochemical properties for water splitting.

“Nano-lymphatic” photocatalytic water-splitting for relieving tumor interstitial fluid pressure and achieving hydrodynamic therapy

2020 ◽  
Vol 7 (12) ◽  
pp. 3266-3274
Author(s):  
Cong Cong ◽  
Cheng Rao ◽  
Zhenhe Ma ◽  
Menghan Yu ◽  
Yaqian He ◽  
...  
Keyword(s):  
Water Splitting ◽  
Interstitial Fluid ◽  
Tumor Therapy ◽  
Fluid Pressure ◽  
Interstitial Fluid Pressure ◽  
Deep Penetration ◽  
Photocatalytic Water Splitting ◽  
Tumor Interstitial Fluid

The “nano-lymphatic” mediated hydrodynamics therapy for reducing tumor interstitial fluid pressure, effective deep penetration and anti-tumor therapy.

A 2D/1D TiO2 nanosheet/CdS nanorods heterostructure with enhanced photocatalytic water splitting performance for H2 evolution

2018 ◽  
Vol 43 (15) ◽  
pp. 7388-7396 ◽  
Author(s):  
Junmei Wang ◽  
Zhijian Wang ◽  
Peng Qu ◽  
Qinchao Xu ◽  
Jianfeng Zheng ◽  
...  
Keyword(s):  
Water Splitting ◽  
H2 Evolution ◽  
Photocatalytic Water Splitting ◽  
Cds Nanorods

Photocatalytic Hydrogen Production from Water Splitting on CdS and Cd0.8Zn0.2S Nanorods: Influence of Ni(OH)2 Modification

2013 ◽  
Vol 805-806 ◽  
pp. 1291-1296 ◽  
Author(s):  
Juan Li ◽  
Xin Jun Li
Keyword(s):  
Hydrogen Production ◽  
Water Splitting ◽  
Solar Irradiation ◽  
Precipitation Method ◽  
X Ray Diffraction ◽  
Visible Absorption ◽  
Cds Nanorods ◽  
Transmission Electron ◽  
Composite Photocatalysts ◽  
Simulated Solar Irradiation

The composite photocatalysts of Ni (OH)2modified Cd1-xZnxS (x=0, 0.2) nanorods were synthesized via a simple deposition-precipitation method using nanorods as support and Ni (NO3)2as nickel hydroxide precursor. The structures, morphologies and optical properties of the catalysts were characterized by X-ray diffraction, scanning electron microscopy, high resolution transmission electron spectroscopy and UV-visible absorption spectroscopy. The photoactivities of the catalysts were examined toward hydrogen production by water splitting under simulated solar irradiation. Results show that the catalyst of Ni (OH)2-Cd0.8Zn0.2S nanorods exhibits a significantly enhanced H2-production activity in compared to the Ni (OH)2-CdS nanorods. The reason for the different effects of Ni (OH)2modification on the photoactivities of the two catalysts was discussed, and the possible mechanism related to the photocatalytic process was proposed.

scholarly journals Au/CdS Core-Shell Sensitized Actinomorphic Flower-Like ZnO Nanorods for Enhanced Photocatalytic Water Splitting Performance

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 233
Author(s):  
Ying Li ◽  
Tie Liu ◽  
Shuang Feng ◽  
Wenshu Yang ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Water Splitting ◽  
Zno Nanorods ◽  
Photogenerated Electron ◽  
Cds Nanoparticles ◽  
Electron Recombination ◽  
Ternary Composite ◽  
Photocatalytic Water Splitting ◽  
Co Catalysts ◽  
Cds Nanorods ◽  
Application Potential

Herein, a novel actinomorphic flower-like ZnO/Au/CdS nanorods ternary composite photocatalyst is prepared to extend the light-responsive range, reduce the photogenerated charge carriers recombination, and ultimately improve the water splitting performance. Flower-like ZnO nanorods are synthesized by a chemical bath method and the CdS nanoparticles are sensitized by successive ionic layer adsorption and reaction method. Then the Au nanoparticles as co-catalysts are introduced by the photodeposition method to modify the interface of ZnO/CdS for reducing the photogenerated electron recombination rate and further improving the performance of water splitting. Detailed characterizations and measurements are employed to analyse the crystallinity, morphology, composition, and optical properties of the flower-like ZnO/Au/CdS nanorods samples. As a result, the flower-like ZnO/Au/CdS nanorod samples present significantly enhanced water splitting performance with a high gas evolution rate of 502.2 μmol/g/h, which is about 22.5 and 1.5 times higher than that of the pure ZnO sample and ZnO/CdS sample. The results demonstrate that the flower-like ZnO/Au/CdS nanorods ternary composite materials have great application potential in photocatalytic water splitting for the hydrogen evolution field.

Sign in / Sign up

Export Citation Format

Share Document