This chapter suggests, contrary to views such as those expressed in Terry Eagleton’s Heathcliff and the Great Hunger (1995), that political economy was not ‘a gross, materialist language, heavy with biological ballast’, but rather a set of abstractions based on moral judgement and laissez-faire approaches to wealth and well-being. Looking at the major works that pioneered dietetics, gut physiology, and hunger therapeutics, it sets out how scientists, surgeons, and doctors offered an alternative narrative of hunger as unnecessary, unjust, and unnatural. Comparing understandings of famine and sickness during the Irish Hunger against the ill-assumed confidence of statisticians, Chapter 1 also studies how science developed a critically sophisticated, multi-textured mode of exploring the meanings, languages, and repercussions of hunger.