Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature

Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstruction symptoms and was subjected to a transurethral prostatic resection (TURP). Histologically, there is a diffuse proliferation of epithelioid and spindle cells that showed rare atypical mitotic figures. Immunohistochemically, the neoplastic cells express diffusely CD34 and focally progesterone whereas no immunoreactivity was seen for cytocheratin, desmin, S-100, Bcl-2, chromogranin, CD117, and actin smooth muscle. A final diagnosis of low-grade prostatic stromal sarcoma (LG-PS) was made. This is a really rare neoplasm; in the literature, in fact, to our knowledge, only 6 cases are described and all of these were alive and free of disease at followup. Our patient too is free of disease at 15 months from the diagnosis.

Fine Needle Aspiration Cytology of Prostatic Lesions with Histologic Correlation

Cytologic diagnosis by fine needle aspiration of the prostate was compared to histological diagnosis by either core biopsy or transurethral prostatic resection in 58 patients suspected to have prostatic lesion by rectal examination.The diagnostic accuracy between cytological and histological diagnosis was 93% and the false negative rate was 3.03% for fine needle aspiration. Inadequate cytological samples occurred only in two cases. This study was conducted during the period of April 2003 to February 2004. Fine needle aspiration cytology of prostatic lesions is a recently introduced procedure in Bangladesh. Our results indicate that fine needle aspiration is an easily performed, diagnostically reliable outpatient procedure with minimal complication. Ibrahim Med. Coll. J. 2007; 1(1): 7-10 Key words : FNAC, Franzen, Papaniculaou doi: 10.3329/imcj.v1i1.2888