serum free thyroxine
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2020 ◽  
Vol 11 ◽  
Author(s):  
Salvatore Benvenga

Pharmacological interference on L-thyroxine (L-T4) therapy can be exerted at several levels, namely from the hypothalamus/pituitary through the intestine, where the absorption of exogenous L-T4 takes place. A number of medications interfere with L-T4 therapy, some of them also being the cause of hypothyroidism. The clinician should be aware that some medications simply affect thyroid function tests with no need of modifying the dose of L-T4 that the patient was taking prior to their prescription. Usually, the topic of pharmacological interference on L-T4 therapy addresses the patient with primary hypothyroidism, in whom periodic measurement of serum thyrotropin (TSH) is the biochemical target. However, this minireview also addresses the patient with central hypothyroidism, in whom the biochemical target is serum free thyroxine (FT4). This minireview also addresses two additional topics. One is the costs associated with frequent monitoring of the biochemical target when L-T4 is taken simultaneously with the interfering drug. The second topic is the issue of metabolic/cardiovascular complications associated with undertreated hypothyroidism.


2020 ◽  
pp. 088307382096292 ◽  
Author(s):  
Bahareh Michelle Schweiger ◽  
Aaron-James Lao ◽  
Jane Tavyev

Many medications can impact thyroid function. Antiseizure medications have been shown to disrupt thyroid function in adults, but information is limited about how antiseizure medications may affect thyroid function in children. Oxcarbazepine is an analog of carbamazepine designed to minimize effects from the hepatic P450 metabolic enzymes. We have found that in the pediatric population, serum free thyroxine is reduced and thyroid-stimulating hormone concentrations are unchanged in patients taking oxcarbazepine with the mechanism thus being central hypothyroidism.


2020 ◽  
Vol 125 (8) ◽  
pp. 1162-1169 ◽  
Author(s):  
Patrick Müller ◽  
Johannes W. Dietrich ◽  
Tina Lin ◽  
Alexandru Bejinariu ◽  
Stephan Binnebößel ◽  
...  

2020 ◽  
Vol 35 (1) ◽  
pp. 106 ◽  
Author(s):  
Mijin Kim ◽  
Bo Hyun Kim ◽  
Hyungi Lee ◽  
Min Hee Jang ◽  
Jeong Mi Kim ◽  
...  

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8163
Author(s):  
Haoyu Wang ◽  
Aihua Liu ◽  
Yingying Zhou ◽  
Yue Xiao ◽  
Yumeng Yan ◽  
...  

Thyroid ◽  
2017 ◽  
Vol 27 (7) ◽  
pp. 886-893 ◽  
Author(s):  
Ladan Mehran ◽  
Atieh Amouzegar ◽  
Mahmood Bakhtiyari ◽  
Mohammad Ali Mansournia ◽  
Parnian Kheirkhah Rahimabad ◽  
...  

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