Layer-Specific Residual Deformations and Their Variation Along the Human Aorta

This study described the regional distribution of layer-specific residual deformations in fifteen human aortas collected during autopsy. Circumferentially- and axially-cut strips of standardized dimensions from the anterior quadrant of nine consecutive aortic levels were photographed to obtain the zero-stress state for the intact wall. The strips were then dissected into layers that were also photographed to obtain their zero-stress state. Changes in layer-specific opening angle, residual stretches, and thickness at each aortic level and direction were determined via image analysis. The circumferential and axial opening angles of the intima were ~240° and ~30°, respectively, throughout the aorta; those of the adventitia were ~150° and -20° to 70°. The opening angles of the intact wall and media were similar in either direction. The circumferential residual stretches of the intima and the axial residual stretches of the media showed high values in the aortic arch, decreasing in the descending thoracic aorta and increasing toward the iliac artery bifurcation, while the axial residual stretches of the adventitia increased distally. The remaining residual stretches did not vary significantly with aortic level, suggesting an intimal role in determining circumferential, as well as medial and adventitial roles in determining axial residual stretches. We conclude that the tensile residual stretches released in the intima and media upon separation, and the compressive residual stretches released in the adventitia may moderate the inverse transmural stress gradients under physiologic loads, resulting from the >180° circumferential opening angle of the intact wall.

Wave generation characteristic analysis of piston and flap type wave maker with rotary-valve-control vibrator

Wave maker is one of the most important experimental equipment in marine engineering. To meet the demands of simulation of higher wave amplitude and compare the effect of piston and flap type wave generation, a new wave generation device was proposed and a new piston and flap type wave maker with a rotary-valve-control vibrator was developed. A mathematical model of the new wave maker was established and analysed by Simulink, and a series of experiments were conducted on the wave maker to analyze wave generation characteristics. The results show that the wave maker can adjust the distance of wave paddle and generate different regular waves. The bigger the axial opening size of the valve port, the larger the wave paddle amplitude and the wave amplitude; the higher the pressure, the higher the wave paddle amplitude and the wave amplitude. High frequency wave making is more efficient than the lower one, and piston type wave making is more efficient than those wave makers that generate waves by flap type.

Variation of Axial Residual Strains Along the Course and Circumference of Human Aorta Considering Age and Gender

Our understanding of aortic biomechanics is customarily limited by lack of information on the axial residual stretches of the vessel in both humans and experimental animals that would facilitate the identification of its actual zero-stress state. The aim of this study was thus to acquire hitherto unreported quantitative knowledge of axial opening angle and residual stretches in different segments and quadrants of the human aorta according to age and gender. Twenty-three aortas were harvested during autopsy from the aortic root to the iliac bifurcation and were divided into ≥12 segments and 4 quadrants. Morphometric measurements were taken in the excised/curled configuration of rectangular strips considered to be under zero-stress using image-analysis software to study the axial/circumferential variation of axial opening angle, internal/external residual stretch, and thickness of the aortic wall. The measured data demonstrated: (1) an axial opening angle peak at the arch branches, decreasing toward the ascending and to a near-constant value in the descending thoracic aorta, and increasing in the abdominal aorta; (2) the variation of residual stretches resembled that of opening angle, but axial differences in external residual stretch were more prominent; (3) wall thickness showed a progressive diminution along the vessel; (4) the highest opening angle/residual stretches were found in the inner quadrant and the lowest in the outer quadrant; (5) the anterior was the thinnest quadrant throughout the aorta; (6) age caused thickening but greatly reduced axial opening angle/residual stretches, without differences between males and females.