oxidative drug metabolism
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scholarly journals Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds

2020 ◽  
Vol 11 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Phillip R. Lazzara ◽  
Terry W. Moore
Keyword(s):  
Drug Metabolism ◽  
Aromatic Compounds ◽  
Medicinal Chemistry ◽  
Lead Optimization ◽  
Scaffold Hopping ◽  
Oxidative Drug Metabolism

Mitigating oxidative drug metabolism is an important component of lead optimization. This review focuses on scaffold-hopping strategies used in the recent medicinal chemistry literature to address metabolic liabilities of aromatic compounds.

Voltammetric and electrogeneration approaches for the assessment of the oxidative drug metabolism

2018 ◽  
Vol 410 (8) ◽  
pp. 2229-2239 ◽  
Author(s):  
Laura Rodríguez-Cid ◽  
Sonia Sentellas ◽  
Javier Saurina
Keyword(s):  
Drug Metabolism ◽  
Oxidative Drug Metabolism

Electrochemical Oxidation by Square-Wave Potential Pulses in the Imitation of Oxidative Drug Metabolism

2011 ◽  
Vol 83 (14) ◽  
pp. 5519-5525 ◽  
Author(s):  
Eslam Nouri-Nigjeh ◽  
Hjalmar P. Permentier ◽  
Rainer Bischoff ◽  
Andries P. Bruins
Keyword(s):  
Drug Metabolism ◽  
Electrochemical Oxidation ◽  
Square Wave ◽  
Wave Potential ◽  
Oxidative Drug Metabolism

Electrochemistry in the Mimicry of Oxidative Drug Metabolism by Cytochrome P450s

2011 ◽  
Vol 12 (4) ◽  
pp. 359-371 ◽  
Author(s):  
Eslam Nouri-Nigjeh ◽  
Rainer Bischoff ◽  
Andries P. Bruins ◽  
Hjalmar P. Permentier
Keyword(s):  
Drug Metabolism ◽  
Cytochrome P450s ◽  
Oxidative Drug Metabolism

Lidocaine Oxidation by Electrogenerated Reactive Oxygen Species in the Light of Oxidative Drug Metabolism

2010 ◽  
Vol 82 (18) ◽  
pp. 7625-7633 ◽  
Author(s):  
Eslam Nouri-Nigjeh ◽  
Hjalmar P. Permentier ◽  
Rainer Bischoff ◽  
Andries P. Bruins
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Metabolism ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Oxidative Drug Metabolism
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