scholarly journals Prospects on the Hyphenated Electrochemistry and Mass Spectrometry as a Practical Analytical Technique in the Assessment of Oxidative Drug Metabolism

ADMET & DMPK ◽  
2014 ◽  
Vol 2 (3) ◽  
Author(s):  
Eslam Nigjeh
Keyword(s):  
Mass Spectrometry ◽  
Drug Metabolism ◽  
Analytical Technique ◽  
Oxidative Drug Metabolism

Inorganic mass spectrometry

2018 ◽  
Vol 4 (3) ◽  
Author(s):  
Josefina Pérez-Arantegui ◽  
Francisco Laborda
Keyword(s):  
Mass Spectrometry ◽  
High Precision ◽  
Mass Spectrometric ◽  
Sample Introduction ◽  
Mass Separation ◽  
Analytical Technique ◽  
Good Spatial Resolution ◽  
Icp Ms ◽  
Analytical Properties ◽  
Mass Spectrometric Techniques

Abstract Inorganic mass spectrometry has been used as a well-known analytical technique to determine elemental/isotopic composition of very diverse materials, based on the different mass-to-charge ratios of the ions produced in a specific source. In this case, two mass spectrometric techniques are explained and their analytical properties discussed: inductively coupled plasma mass spectrometry (ICP-MS) and thermal ionisation mass spectrometry (TIMS), since they are the most used in art and archaeological material studies. Both techniques combine advantageous analytical properties, like low detection limits, low interferences and high precision. The use of laser ablation as sample introduction system in ICP-MS allows to avoid sample preparation and to perform good spatial-resolution analysis. The development of new instruments, improving the mass separation and the detection of the ions, specially multicollection detectors, results in high-precision isotopic analysis. A summary of the important applications of these mass spectrometric techniques to the analysis of art and archaeological materials is also highlighted.

scholarly journals Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7185
Author(s):  
Oliver Gould ◽  
Natalia Drabińska ◽  
Norman Ratcliffe ◽  
Ben de Lacy Costello
Keyword(s):  
Mass Spectrometry ◽  
Volatile Compounds ◽  
Real Time ◽  
Qualitative Data ◽  
Method Development ◽  
Complex Matrices ◽  
Analytical Technique ◽  
Monitoring Drug ◽  
Highly Sensitive ◽  
Insight Into

Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has resulted in numerous variations of the technique being developed over the years, which can be divided into hyphenated and real-time MS techniques. Hyphenated chromatographic techniques coupled with MS offer unparalleled qualitative analysis and high accuracy and sensitivity, even when analysing complex matrices (breath, urine, stool, etc.). However, these benefits are traded for a significantly longer analysis time and a greater need for sample preparation and method development. On the other hand, real-time MS techniques offer highly sensitive quantitative data. Additionally, real-time techniques can provide results in a matter of minutes or even seconds, without altering the sample in any way. However, real-time MS can only offer tentative qualitative data and suffers from molecular weight overlap in complex matrices. This review compares hyphenated and real-time MS methods and provides examples of applications for each technique for the detection of VCs from humans.

Sign in / Sign up

Export Citation Format

Share Document