A renal and hepatic toxicity analysis of remdesivir formulations: Does what is on the inside really count?

It has been postulated that the injectable solution formulation of remdesivir could be more nephrotoxic than the lyophilized powder since it contains twice as much sulfobutylether-β-cyclodextrin (SBECD). Therefore, we evaluated 1000 hospitalized patients with SARS-CoV-2 who received remdesivir lyophilized powder or solution. A logistic regression model accounting for baseline confounders identified that neither the use of the injectable solution (OR = 1.05; 95% CI = 0.49-2.29; P=0.901) nor a Creatinine Clearance < 30ml/min at the time of remdesivir initiation (OR = 1.39; 95% CI = 0.51-3.5; P=0.499) were significantly associated with acute kidney injury. Regarding hepatoxicity, there was no significant difference in early discontinuation of remdesivir due to abnormal Liver Function Tests between patients who received the lyophilized powder versus solution (0.9% vs 2.3%, P= 0.09).

Solid-state versus solution investigation of a luminescent chiral BINOL-derived bisphosphate single-molecule magnet

The enantiopure coordination polymer [Dy(hfac)3((S/R)-L)]n ([(S/R)-1]n) involving a BINOL-derived bisphosphate ligand (S/R)-L is investigated both in solution and solid-state.

Surface versus solution chemistry: manipulating nanoparticle shape and composition through metal–thiolate interactions

The introduction of organic additives to seeded growth strategies is allowing for high quality nanoparticles to be achieved. Here, thiophenol derivatives are introduced to simultaneously control nanoparticle symmetry and composition.

Spectrophotometric Determination of Chromium Using Indigo Carmine -Application in Various Samples

A rapid, simple and sensitive spectrophotometric method for the determination of trace amounts of chromium is studied. The method is based on the interaction of chromium with indigo carmine dye in acidic medium and the presence of oxalates as a catalyst for interaction, and after studying the absorption spectrum of the solution resulting observed decrease in the intensity of the absorption. As happened (Bleaching) for color dye, this palace and directly proportional to the chromium (VI) amount was measured intensity of the absorption versus solution was figurehead at a wavelength of 610 nm. A plot of absorbance with chromium (VI) concentration gives a straight line indicating that Beer’s law has been obeyed over the range of 0.5 -70 µg /25 ml, i.e., 0.02- 2.8 ppm with a molar absorptivity of chromium (VI) 1.71? 104 l.mol-1.cm-1, Sandell’s sensitivity index of 0.0030 µg.cm-2 .The detection limit of chromium was (DL) 0.0012 µg.mL-1 and a relative standard deviation of ? (0.70 -1.86)% depended on the concentration level. The method is developed for the determination of chromium(III) and has been successfully applied to the determination of chromium in various water samples, Pharmaceutical preparations ,standard rock sample of (MRG-1).