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Author(s):  
Sunish Shah ◽  
Tyler W. Ackley ◽  
Jeffrey E. Topal

It has been postulated that the injectable solution formulation of remdesivir could be more nephrotoxic than the lyophilized powder since it contains twice as much sulfobutylether-β-cyclodextrin (SBECD). Therefore, we evaluated 1000 hospitalized patients with SARS-CoV-2 who received remdesivir lyophilized powder or solution. A logistic regression model accounting for baseline confounders identified that neither the use of the injectable solution (OR = 1.05; 95% CI = 0.49-2.29; P=0.901) nor a Creatinine Clearance < 30ml/min at the time of remdesivir initiation (OR = 1.39; 95% CI = 0.51-3.5; P=0.499) were significantly associated with acute kidney injury. Regarding hepatoxicity, there was no significant difference in early discontinuation of remdesivir due to abnormal Liver Function Tests between patients who received the lyophilized powder versus solution (0.9% vs 2.3%, P= 0.09).


Author(s):  
Carlo Andrea Mattei ◽  
Vincent Montigaud ◽  
Frédéric Gendron ◽  
Sandrine Denis-Quanquin ◽  
Vincent Dorcet ◽  
...  

The enantiopure coordination polymer [Dy(hfac)3((S/R)-L)]n ([(S/R)-1]n) involving a BINOL-derived bisphosphate ligand (S/R)-L is investigated both in solution and solid-state.


2020 ◽  
Vol 2020 (45) ◽  
pp. 7051-7061
Author(s):  
Michaela Wernik ◽  
Peter E. Hartmann ◽  
Gellért Sipos ◽  
Ferenc Darvas ◽  
A. Daniel Boese ◽  
...  

Nanoscale ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 512-519 ◽  
Author(s):  
Joshua D. Smith ◽  
Connor M. Bunch ◽  
Yuda Li ◽  
Kallum M. Koczkur ◽  
Sara E. Skrabalak

The introduction of organic additives to seeded growth strategies is allowing for high quality nanoparticles to be achieved. Here, thiophenol derivatives are introduced to simultaneously control nanoparticle symmetry and composition.


2017 ◽  
Vol 56 (22) ◽  
pp. 13697-13708 ◽  
Author(s):  
Santiago Rodríguez-Jiménez ◽  
Sally Brooker

2016 ◽  
Vol 13 (3) ◽  
pp. 556-567
Author(s):  
Baghdad Science Journal

A rapid, simple and sensitive spectrophotometric method for the determination of trace amounts of chromium is studied. The method is based on the interaction of chromium with indigo carmine dye in acidic medium and the presence of oxalates as a catalyst for interaction, and after studying the absorption spectrum of the solution resulting observed decrease in the intensity of the absorption. As happened (Bleaching) for color dye, this palace and directly proportional to the chromium (VI) amount was measured intensity of the absorption versus solution was figurehead at a wavelength of 610 nm. A plot of absorbance with chromium (VI) concentration gives a straight line indicating that Beer’s law has been obeyed over the range of 0.5 -70 µg /25 ml, i.e., 0.02- 2.8 ppm with a molar absorptivity of chromium (VI) 1.71? 104 l.mol-1.cm-1, Sandell’s sensitivity index of 0.0030 µg.cm-2 .The detection limit of chromium was (DL) 0.0012 µg.mL-1 and a relative standard deviation of ? (0.70 -1.86)% depended on the concentration level. The method is developed for the determination of chromium(III) and has been successfully applied to the determination of chromium in various water samples, Pharmaceutical preparations ,standard rock sample of (MRG-1).


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