Postural freezing foretells startle-potentiation in a human fear-conditioning paradigm

Freezing to impending threat is a core defensive response. It has been studied primarily using fear-conditioning in non-human animals, thwarting advances in translational human anxiety-research. Here we examine postural freezing as a human conditioning-index for translational anxiety-research. We show (n=28) that human freezing is highly sensitive to fear-conditioning, generalizes to ambiguous contexts, and amplifies with threat-imminence. Intriguingly, stronger parasympathetically-driven freezing under threat, but not sympathetically-mediated skin conductance, predicts subsequent startle magnitude. These results demonstrate that humans show fear-conditioned animal-like freezing responses, known to aid in active preparation for unexpected attack, and that freezing captures real-life anxiety-expression. Conditioned freezing offers a promising new, non-invasive, and continuous, readout for human fear-conditioning, paving the way for future translational studies into human fear and anxiety.

Birth Preparedness and Complication Readiness among Antenatal Women in a Tribal Area of a Central District, Kerala

Background: Obstetric complications and maternal deaths following childbirth becomes a burden on many women and their families. Birth preparedness and complication readiness is a comprehensive package which aims at promoting timely access to skilled maternal and neonatal services. It focuses on the active preparation and decision making process in the delivery of pregnant ladies and their families. Objective: To assess birth preparedness and complication readiness among antenatal women in a tribal area, central zone Kerala. Methodology: This was a community based cross-sectional study carried out in a tribal area during January – June 2019 among 60 tribal antenatal women using a questionnaire based interview

Sustained visual priming effects can emerge from attentional oscillation and temporal expectation

Priming refers to the influence that a previously encountered object exerts on future responses to similar objects. For many years, visual priming has been known as a facilitation and sometimes an inhibition effect that lasts for an extended period of time. It contrasts with the recent finding of an oscillated priming effect where facilitation and inhibition alternate over time periodically. Here we developed a computational model of visual priming that combines rhythmic sampling of the environment (attentional oscillation) with active preparation for future events (temporal expectation). Counterintuitively, it shows both the sustained and oscillated priming effects can emerge from an interaction between attentional oscillation and temporal expectation. The interaction also leads to novel predictions such as the change of visual priming effects with temporal expectation and attentional oscillation. Reanalysis of two published datasets and the results of two new experiments of visual priming tasks with male and female human participants provide support for the model’s relevance to human behavior. More generally, our model offers a new perspective that may unify the increasing findings of behavioral and neural oscillations with the classic findings in visual perception and attention.Significance StatementThere is increasing behavioral and neural evidence that visual attention is a periodic process that sequentially samples different alternatives in the theta frequency range. It contrasts with the classic findings of sustained facilitatory or inhibitory attention effects. How can an oscillatory perceptual process give rise to sustained attention effects? Here we make this connection by proposing a computational model for a “fruit fly” visual priming task and showing both the sustained and oscillated priming effects can have the same origin: an interaction between rhythmic sampling of the environment and active preparation for future events. One unique contribution of our model is to predict how temporal contexts affects priming. It also opens up the possibility of reinterpreting other attention-related classic phenomena.

The interplay of crossmodal attentional preparation and modality compatibility in cued task switching

Two experiments examined the influence of preparation on modality compatibility effects in task switching. The term modality compatibility refers to the similarity between the stimulus modality and the modality of response-related sensory consequences. Previous research showed evidence for modality compatibility benefits in task switching when participants switched either between two modality compatible tasks (auditory-vocal and visual-manual) or between two modality incompatible tasks (auditory-manual and visual-vocal). In this study, we investigated the influence of active preparation on modality compatibility effects in task switching. To this end, in Experiment 1, we introduced unimodal modality cues, whereas in Experiment 2, bimodal abstract cues were used. In both experiments, the cue-stimulus interval (CSI) was manipulated while holding the response-stimulus interval (RSI) constant. In both experiments, we found not only decreased switch costs with long CSI but also the elimination of the residual switch costs. More importantly, this preparation effect did not modulate the modality compatibility effect in task switching. To account for this data pattern, we assume that cue-based preparation of switches by modality mappings was highly effective and produced no residual reaction time (RT) costs with long CSI.

Structure of the deactive state of mammalian respiratory complex I

Complex I (NADH:ubiquinone oxidoreductase) is central to energy metabolism in mammalian mitochondria. It couples NADH oxidation by ubiquinone to proton transport across the energy-conserving inner membrane, catalyzing respiration and driving ATP synthesis. In the absence of substrates, ‘active’ complex I gradually enters a pronounced resting or ‘deactive’ state. The active-deactive transition occurs during ischemia and is crucial for controlling how respiration recovers upon reperfusion. Here, we set a highly-active preparation of Bos taurus complex I into the biochemically-defined deactive state, and used single-particle electron cryomicroscopy to determine its structure to 4.1 Å resolution. The deactive state arises when critical structural elements that form the ubiquinone-binding site become disordered, and we propose reactivation is induced when substrate binding templates their reordering. Our structure both rationalizes biochemical data on the deactive state, and offers new insights into its physiological and cellular roles.

Involvement of male in birth preparedness in Tulsipur municipality of Dang district, Nepal

Male in patriarchal societies of developing countries are identified as decision makers in all aspects of life. Every pregnant woman faces risk of life-threatening obstetric complications. A birth-preparedness package promotes active preparation and assists in decision-making for healthcare seeking in case of such complications. The present study attempted to assess the involvement of male in birth preparedness in Tulsipur Municipality of Dang District. A Descriptive Cross Sectional Study was conducted among 125 male including husbands of pregnant women and fathers of under one children in 2011, to assess the involvement of male in birth preparedness. Purposively record was reviewed from the Rapti Zonal Hospital as well as Municipality office, and respondent were identified using snowball sampling from community. More than half 52.8% of the respondents heard about Birth Preparedness. Nearly half 44.36% of the respondents plan for preparedness of birth, more than half 56.8% had thought to plan if emergency situation or complication arises during pregnancy and childbirth. Most 69.6% of the respondent has planned the place for giving birth to their child. Nearly half 51.8 % of respondent have plan for visiting their wives to Skill Birth Attendants. Only few 12.5% of the husbands had planned for transportation facility and identified Blood Donors if required’. About half 48% of the husbands are accompanying their wife for Antenatal Care. Most 88% of the husbands help their wives in household activities during pregnancy and childbirth. It shows that about half of the male were involved in Birth Preparedness.

Mental and Active Preparation: Examining Variations in Women’s Processes of Preparing to Leave Abusive Relationships

Although the process of leaving abusive relationships has received increased research attention, preparing to leave is still largely understudied. Despite an emphasis on safety planning, not all women take active steps to prepare, and the characteristics and experiences of those who do or do not actively prepare are unknown. We address this gap with a secondary data analysis of interviews with 25 abused mothers in the process of leaving. All women initially engaged in mental planning, where they had emotionally disconnected from their partners. Using constructivist grounded theory techniques, we identified two distinct groups: those whose mental planning led to active planning ( n = 11), and those who moved directly from mental planning to leaving ( n = 14) with little time or need to actively plan. The groups differed on several individual, relationship, and child factors, which may have impacted the ability or decisions to prepare. This study supports the feminist view that survivors are not helpless victims but active agents who strategize for safety. Those who engage solely in mental planning still prepare to leave, even if they do not engage in active planning. Practitioners should consider factors affecting preparations and acknowledge mental planning as a necessary effort in leaving.