sponge matrix
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2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Talal Al-Nahlawi ◽  
Maisour Ala Rachi ◽  
Amjad Abu Hasna

Endodontic perforations are common accidents that occasionally happen as a result of misuse or difficult anatomy of some teeth; it may lead to teeth loss unless a good management is provided. Bioceramic (silicate-based) cements like mineral trioxide aggregate have a big role in management of such accidents. This case report aimed to evaluate the ability of five mineral oxides cement “5MO” in sealing two root canal perforations (furcation and postdrill perforations) and inducing clinical and radiographic healing in the periodontal tissues with/without the use of collagen sponge matrix. A 58-year-old healthy female was referred to our dental office complaining of severe pain in the upper left premolars’ region. Periapical radiographic examination revealed unsatisfactory root canal treatment of the teeth #24 and #25 with a furcation perforation and a postdrill perforation, respectively. Cone-beam computed tomography “CBCT” scans confirmed the findings of the periapical radiography and revealed the presence of radiolucent lesions surrounding the apex of both teeth #24 and #25. The treatment plan was a nonsurgical root canal retreatment by endodontic access through the full-ceramic crowns. After three years of follow-up, CBCT scans revealed a complete healing and bone formation on both premolars. This case report indicates the use of 5MO cement for endodontic perforations management.


2016 ◽  
Vol 70 (9) ◽  
Author(s):  
Mária Hnátová ◽  
Dušan Bakoš ◽  
L’udmila Černáková ◽  
Monika Michliková

AbstractBiocompatible polymer sponge materials based on biodegradable natural polymer chitosan, which can be loaded with clinician-selected drugs are still in the centre of interest for their wide use in clinical practice. This study shows possibilities of the technology which combines simple addition of β-cyclodextrin (β-CD), with dialdehyde starch (DAS) as a cross-linking agent of chitosan, to chitosan solutions for subsequent formation of sponge matrix. The advantage of such system is in avoiding chemical modifications and working only with natural substances. It is shown that, in matrix formation during lyophilisation, β-CD molecules tend to accumulate on the surface of the porous matrix structure. This was confirmed by a study of the known inclusion complex of β-CD and salicylic acid (SA) in heptane. The same study was applied to berberine (BER) which can also form an inclusion complex with β-CD in a water solution. Moreover, adsorption of drugs on the surface of the porous structure has to be also taken into account. This enables the production of sponge topical medical preparations useful for sustained release of BER.


2015 ◽  
Vol 96 (7) ◽  
pp. 2410-2417 ◽  
Author(s):  
Camila Ortiz Martinez ◽  
Suelen Pereira Ruiz ◽  
Vanderson Carvalho Fenelon ◽  
Gutierrez Rodrigues de Morais ◽  
Mauro Luciano Baesso ◽  
...  
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Author(s):  
Manijeh Goldberg ◽  
Aaron Manzi ◽  
Erkin Aydin ◽  
Gurtej Singh ◽  
Payam Khoshkenar ◽  
...  

The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix. CSM is intended to be administered topically and locally to mucosal tissues, with its initial indication being oral cancer (OC). Currently, intravenous (IV) administered CDDP is the gold standard chemotherapeutic agent used in the treatment of OC. However, its clinical use has been limited by its renal and hemotoxicity profile. We aim to locally administer CDDP via encapsulation in CS NPs and deliver them directly to the oral cavity with CSM. It is hypothesized that such a delivery device will greatly reduce any systemic toxicity and increase antitumor efficacy. This paper describes the methods for developing CSM and maintaining the integrity of CDDP NPs embedded in the CSM.


2012 ◽  
Vol 36 (1) ◽  
pp. 383-388 ◽  
Author(s):  
Suchitra Banerjee ◽  
Sailendra Singh ◽  
Harshita Pandey ◽  
Pallavi Pandey ◽  
Laiq ur Rahman

2010 ◽  
Vol 64 (5) ◽  
pp. 352-358 ◽  
Author(s):  
Nobuhito Shibata ◽  
Asako Nishumura ◽  
Kazumasa Naruhashi ◽  
Yurie Nakao ◽  
Rieko Miura

2001 ◽  
Vol 7 (4) ◽  
pp. 415-427 ◽  
Author(s):  
Takashi Moriyama ◽  
Izumi Asahina ◽  
Masatoshi Ishii ◽  
Mitsuo Oda ◽  
Yoshimasa Ishii ◽  
...  

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