scholarly journals Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents

2014 ◽  
Vol 5 (4) ◽  
Author(s):  
Manijeh Goldberg ◽  
Aaron Manzi ◽  
Erkin Aydin ◽  
Gurtej Singh ◽  
Payam Khoshkenar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Standard ◽  
Chemotherapeutic Agent ◽  
Chemotherapeutic Agents ◽  
Local Administration ◽  
Clinical Use ◽  
Delivery Device ◽  
Mucosal Tissues ◽  
The Matrix ◽  
Sponge Matrix

The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix. CSM is intended to be administered topically and locally to mucosal tissues, with its initial indication being oral cancer (OC). Currently, intravenous (IV) administered CDDP is the gold standard chemotherapeutic agent used in the treatment of OC. However, its clinical use has been limited by its renal and hemotoxicity profile. We aim to locally administer CDDP via encapsulation in CS NPs and deliver them directly to the oral cavity with CSM. It is hypothesized that such a delivery device will greatly reduce any systemic toxicity and increase antitumor efficacy. This paper describes the methods for developing CSM and maintaining the integrity of CDDP NPs embedded in the CSM.

Molecular Imprinted Hydrogels in Drug Delivery Applications

2015 ◽  
Vol 1797 ◽  
Author(s):  
Jeffrey S. Bates ◽  
Luke R. Whitson ◽  
Kelan M. Albertson ◽  
Nathan S. Hickerson ◽  
Patrick E. Nichols ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Binding Sites ◽  
Covalent Bonding ◽  
Van Der Waals Interactions ◽  
Delivery Device ◽  
Glaucoma Medication ◽  
Reversible Binding ◽  
Drug Delivery Device ◽  
Vis Spectroscopy ◽  
The Matrix

ABSTRACTMolecular imprinting is the process by which molecules are imprinted into the matrix of a material through non-covalent bonding, including hydrogen bonding and van der Waals interactions. In this study hydrogels were imprinted with glaucoma medication with the purpose of creating a reusable ocular drug delivery device with reversible binding sites. The material was synthesized and tested with UV-Vis spectroscopy to determine the concentration of the released drug after twelve hours in distilled water. Modifications were made to the polymer to explore methods required for the proper delivery of the drug over an adequate period of time.

scholarly journals Improved i.p. drug delivery with bioadhesive nanoparticles

2016 ◽  
Vol 113 (41) ◽  
pp. 11453-11458 ◽  
Author(s):  
Yang Deng ◽  
Fan Yang ◽  
Emiliano Cocco ◽  
Eric Song ◽  
Junwei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Chemotherapeutic Agent ◽  
Abdominal Cavity ◽  
Lymphatic Drainage ◽  
Chemotherapeutic Agents ◽  
Serous Carcinoma ◽  
Epothilone B ◽  
Peritoneal Space ◽  
Uterine Serous Carcinoma

The i.p. administration of chemotherapy in ovarian and uterine serous carcinoma patients by biodegradable nanoparticles may represent a highly effective way to suppress peritoneal carcinomatosis. However, the efficacy of nanoparticles loaded with chemotherapeutic agents is currently hampered by their fast clearance by lymphatic drainage. Here, we show that a unique formulation of bioadhesive nanoparticles (BNPs) can interact with mesothelial cells in the abdominal cavity and significantly extend the retention of the nanoparticles in the peritoneal space. BNPs loaded with a potent chemotherapeutic agent [epothilone B (EB)] showed significantly lower systemic toxicity and higher therapeutic efficacy against i.p. chemotherapy-resistant uterine serous carcinoma-derived xenografts compared with free EB and non-BNPs loaded with EB.

scholarly journals Trends in Nanotechnology for the Treatment of Breast Cancer

2020 ◽  
pp. 42-57
Author(s):  
Sonali B. Diwate ◽  
Ziyaurrahmam Ataurrahman ◽  
Kiran S. Bhise
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Chemotherapeutic Agent ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Innovative Drug ◽  
Nanodrug Delivery

Breast cancer is the most common and progressively increased form of cancer mostly among women. Various therapies have been tried to cure this cancer but none of them is without side effect. These might be attributed to the indiscriminate destruction of normal cells along with cancer cells or other systemic effects of the chemotherapeutic agent. These difficulties initiate the urge to develop targeted drug delivery systems. Nanotechnology deals with formulation of nanostructures for innovative drug delivery. Nanodrug delivery systems are being used for targeting in the treatment of various diseases, hence this concept is also applicable to the treatment of breast cancer. Nanoparticles have an additional effect of improvement in the solubility of drugs such as paclitaxel, reduction in dose and toxicity, increased cellular uptake etc. Owing to smaller size these are easily taken by tumor cells and effectively encapsulate the hydrophobic drugs. This review is aimed to summarize the various management therapies majorly focusing on the recent nanodrug delivery systems to target chemotherapeutic agents in the breast cancer cells. Various nanodrug systems are in clinical trials and few of them are already in the market. These are promising tools for future cancer treatment and research.

Emodin Enhances the Chemosensitivity of Endometrial Cancer by Inhibiting ROS-Mediated Cisplatin-resistance

2018 ◽  
Vol 18 (7) ◽  
pp. 1054-1063 ◽  
Author(s):  
Ning Ding ◽  
Hong Zhang ◽  
Shan Su ◽  
Yumei Ding ◽  
Xiaohui Yu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Endometrial Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Agent ◽  
Annexin V ◽  
Chemotherapeutic Agents ◽  
Endometrial Cancer Cell ◽  
Animal Survival ◽  
Apoptosis Level

Background: Endometrial cancer is a common cause of death in gynecological malignancies. Cisplatin is a clinically chemotherapeutic agent. However, drug-resistance is the primary cause of treatment failure. Objective: Emodin is commonly used clinically to increase the sensitivity of chemotherapeutic agents, yet whether Emodin promotes the role of Cisplatin in the treatment of endometrial cancer has not been studied. Method: CCK-8 kit was utilized to determine the growth of two endometrial cancer cell lines, Ishikawa and HEC-IB. The apoptosis level of Ishikawa and HEC-IB cells was detected by Annexin V / propidium iodide double-staining assay. ROS level was detected by DCFH-DA and NADPH oxidase expression. Expressions of drug-resistant genes were examined by real-time PCR and Western blotting. Results: Emodin combined with Cisplatin reduced cell growth and increased the apoptosis of endometrial cancer cells. Co-treatment of Emodin and Cisplatin increased chemosensitivity by inhibiting the expression of drugresistant genes through reducing the ROS levels in endometrial cancer cells. In an endometrial cancer xenograft murine model, the tumor size was reduced and animal survival time was increased by co-treatment of Emodin and Cisplatin. Conclusion: This study demonstrates that Emodin enhances the chemosensitivity of Cisplatin on endometrial cancer by inhibiting ROS-mediated expression of drug-resistance genes.

scholarly journals Preparation and sterilization of an implantable drug-delivery microdevice for clinical use

MethodsX ◽  
2021 ◽  
pp. 101382
Author(s):  
Christine Dominas ◽  
Kyle Deans ◽  
Robert Packard ◽  
Oliver Jonas
Keyword(s):  
Drug Delivery ◽  
Clinical Use

scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

scholarly journals Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

2003 ◽  
Vol 51 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Masako Kajihara ◽  
Toshihiko Sugie ◽  
Hiroo Maeda ◽  
Akihiko Sano ◽  
Keiji Fujioka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Water Soluble ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Novel Drug

scholarly journals Synthesis of mucoadhesive thiol-bearing microgels from 2-(acetylthio)ethylacrylate and 2-hydroxyethylmethacrylate: novel drug delivery systems for chemotherapeutic agents to the bladder

2015 ◽  
Vol 3 (32) ◽  
pp. 6599-6604 ◽  
Author(s):  
M. T. Cook ◽  
S. A. Schmidt ◽  
E. Lee ◽  
W. Samprasit ◽  
P. Opanasopit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Novel Drug

Thiol-bearing microgels have been synthesised from copolymerisation of 2-(acetylthio)ethylacrylate and 2-hydroxyethylmethacrylate, and subsequent deprotection using sodium thiomethoxide.

Aerosol drug delivery: developments in device design and clinical use

The Lancet ◽  
2011 ◽  
Vol 378 (9795) ◽  
pp. 981-982 ◽  
Author(s):  
Bart Rottier ◽  
Floris Grasmeijer ◽  
Paul Hagedoorn ◽  
Anne Haaije de Boer
Keyword(s):  
Drug Delivery ◽  
Clinical Use ◽  
Device Design
Sign in / Sign up

Export Citation Format

Share Document