Pindborg tumour: A case report

The calcifying epithelial odontogenic tumor (CEOT) is a benign epithelial odontogenic lesion that accounts for less than 1% of all odontogenic tumors. CEOT is usually asymptomatic and an incidental radiological finding, often presenting as a mandibular radiolucency with flecks of calcified material. We report a case of CEOT in the right posterior maxilla of a 24-year-old female that was associated with an ectopic unerupted tooth. The tumour in this case caused mild pain and appeared radiographically similar to an odontoma or Ameloblastic fibro-odontome, due to its dense calcified contents. Diagnosis was confirmed through histopathology. This case report highlights the unusual clinical and radiographic appearence of Pindborg tumor.

Pindborg tumour: A case report

The calcifying epithelial odontogenic tumor (CEOT) is a benign epithelial odontogenic lesion that accounts for less than 1% of all odontogenic tumors. CEOT is usually asymptomatic and an incidental radiological finding, often presenting as a mandibular radiolucency with flecks of calcified material. We report a case of CEOT in the right posterior maxilla of a 24-year-old female that was associated with an ectopic unerupted tooth. The tumour in this case caused mild pain and appeared radiographically similar to an odontoma or Ameloblastic fibro-odontome, due to its dense calcified contents. Diagnosis was confirmed through histopathology. This case report highlights the unusual clinical and radiographic appearence of Pindborg tumor.

Case report and review of calcifying epithelial odontogenic tumor

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. CEOT accounts for less than 1% of all odontogenic tumors. This article reports two cases of CEOT with different mode of presentation clinically, radiologically and histologically.

Squamous Odontogenic Tumor of Posterior Maxilla-A Report of a New Unusual Case & Literature Review

Squamous odontogenic tumor is a benign epithelial odontogenic tumor that is very unusual in the maxilla & mandible. Mostly, these are present as single lesions, but rarely they can be multifocal lesions. The nature of maxillary lesions is more aggressive. Because of their benign nature, these lesions are frequently treated with conservative surgical techniques that include curettage and surgical enucleation. We will discuss the instance of a 29-year-old lady who was misdiagnosed and treated conservatively by us. This case was examined in the light of current knowledge of the prevalence, genesis, diagnosis, and treatment of squamous odontogenic tumors, as well as a literature review.

αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion

Ameloblastoma (AB) is the most common benign epithelial odontogenic tumor occurring in the jawbone. AB is a slowly growing tumor but sometimes shows a locally invasive and an aggressive growth pattern with a marked bone resorption. In addition, the local recurrence and distant metastasis of AB also sometimes occurs, which resembles one of the typical malignant potentials. From these points of view, to understand better the mechanisms of AB cell migration or invasion is necessary for the better clinical therapy and improvements of the patients’ quality of life. Microtubules in eukaryotic cells reveal the shape of hollow cylinders made up of polymerized alpha (α)- and beta (β)-tubulin dimers and form the cytoskeleton together with microfilaments and intermediate filaments. Microtubules play important roles in cell migration by undergoing assembly and disassembly with post-translational modifications. Stability of microtubules caused by their acetylation is involved in cell migration. In this study, we investigated the expression and distribution of acetylated α-tubulin and alpha-tubulin N-acetyltransferase 1 (αTAT1), an enzyme which acetylates Lys-40 in α-tubulin, in AB specimens, and analyzed how tubulin was acetylated by αTAT1 activation in a human AB cell line, AM-1. Finally, we clarified that TGF-β-activated kinase1 (TAK1) was phosphorylated by TGF-β stimulation, then, induced tubulin acetylation via αTAT1 activation, which subsequently activated the migration and invasion of AB cells.

Differences between calcifying epithelial odontogenic tumor and calcifying odontogenic cyst through panoramic radiograph: a scoping review

Objectives: This review article is aimed to describe the radiographic features of CEOT and COC to determine the differences between the two lesions on panoramic radiographs. Review: This research is a descriptive study using scoping review method based on the Preferred Reporting Items for Systematic Review and Meta-analysis for Scoping Review (PRISMA-Scr). This study examines English and Indonesian articles of CEOT and COC with panoramic radiography as a diagnostic tool published in 2015 – 2021. Relevant articles were obtained from searches using keywords and inclusion criteria on PubMed, PMC NCBI, and hand searching techniques. A total of 32 articles were identified at initial study identification. Duplication, title and abstract, and full-text inspection consecutively excluded 1, 3, and 8 articles. A total of 20 eligible articles were included in this study, 10 cases of Calcifying Epithelial Odontogenic Tumor and 10 cases of Calcifying Odontogenic Cyst. Conclusion: The differences between COC and CEOT on panoramic radiographs are COC is more commonly found in the anterior region than CEOT and COC tends to occur in the periapical or lateral part of adjacent teeth and causes root resorption, whereas CEOT tends to be located at the crown of impacted teeth. There aren’t any pathognomonic radiographic findings from the CEOT and COC, so a definitive diagnosis still requires histopathological analysis.

An Aggressive Calcifying Epithelial Odontogenic Tumor: A Rare Case Report

Calcifying epithelial odontogenic tumor is an epithelial origin locally aggressive benign odontogenic tumor. It is an extremely rare neoplasm comprise of <1 % of all odontogenic tumors. It manifests clinically as asymptomatic, slow-growing, and locally aggressive lesion which causes expansion of the affected bone. About 400 cases of CEOT (calcifying epithelial odontogenic tumor) are reported in the literature. This article reported a case 18 years old female with a locally aggressive calcifying epithelial odontogenic tumor involving the mandible, without much disfigurement of the face. Aim: The aim of this article to put a drop of water in the ocean of literature. Report a case with aggressive nature.