Synthesizing, Characterizing and Studying the Biological Activity of Some New Schiff-Bases Derivatives Containing the Monosaccharide Moiety

A new series of ?-D-glucose as Schiff bases derivatives is synthesized and characterized with studying their bioactivity. Hydroxyl groups at C (1,2&5,6) sugar moiety are converted into acetal form through a reaction with dry acetone using phosphoric acid and anhydrous zinc chloride as catalysts producing 1,2:5,6-di-O-isopropyledine ?-D-glucofuranose(I). The five memberd ring acetal of C(5,6) is hydrolyzed with acetic acid (65%)and a reaction of the new product with sodium periodate is carried on to get an aldehyde moiety which is used to produce a new series of Schiff bases through reacting with different amino compounds such as 4-amino antipyrene . The suggested chemical structures of the prepared compounds are confirmed by using UV., FT-IR and1 H-NMR spectra .Most of the prepared compounds show antibacterial activity.

Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity

Thiazolidin-4-one is a versatile lead molecule for designing potential bioactive agents. An expeditious method for preparation of 4-thiazolidinones 7(a-h) are an important class of heterocycles, having potential biological importance due to their unique features. The process of convert of imine (Schiff’s base) to 4-thiazolidinone through an intermediate of THF mercapto acetic acid with anhydrous zinc chloride is important synthetic method for preparation of 4-thiazolidinone. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, 13C NMR and Mass spectral studies. The compounds were screened for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Esherichia coli and Pseudomonas aeruginosa was determined by disc diffusion technique. All the synthesized compounds exhibited promising antimicrobial activity against the studied set of microorganisms.

Crystal structure of a mixed-ligand dinuclear Ba—Zn complex with 2-methoxyethanol having triphenylacetate and chloride bridges

The dinuclear barium–zinc complex, μ-chlorido-1:2κ2Cl:Cl-chlorido-2κCl-bis(2-methoxyethanol-1κO)bis(2-methoxyethanol-1κ2O,O′)bis(μ-triphenylacetato-1:2κ2O:O′)bariumzinc, [BaZn(C20H15O2)2Cl2(C3H8O2)4], has been synthesized by the reaction of barium triphenylacetate, anhydrous zinc chloride and 2-methoxyethanol in the presence of toluene. The barium and zinc metal cations in the dinuclear complex are linkedviaone chloride anion and carboxylate O atoms of the triphenylacetate ligands, giving a Ba...Zn separation of 3.9335 (11) Å. The irregular nine-coordinate BaO8Cl coordination centres comprise eight O-atom donors, six of them from 2-methoxyethanol ligands (four from two bidentateO,O′-chelate interactions and two from monodentate interactions), two from bridging triphenylacetate ligands and one from a bridging Cl donor. The distorted tetrahedral coordination sphere of zinc comprises two O-atom donors from the triphenylacetate ligands and two Cl donors (one bridging and one terminal). In the crystal, O—H...Cl, O—H...O and C—H...Cl intermolecular interactions form a layered structure, lying parallel to (001).

Reaction of anhydrous zinc chloride with 2,3-thiophenedicarbaldehyde bis(semicarbazone) (2,3BSTCH2) and bis(thiosemicarbazone) (2,3BTSTCH2): Crystal structure of {[C6H5N2S]+[ZnCl3(C6H4N2S)]−} complex

The reaction of anhydrous zinc chloride with 2,3-thiophenedicarbaldehyde bis(semicarbazone) or 2,3-bis(thiosemicarbazone) leads to the formation of compound {[C

Synthesis of Symmetrical N,N′-Alkylidene Bisamides Using Zinc Chloride as a Lewis Acid Catalyst

N,N-alkylidene bisamides were synthesized with good to excellent yields from aliphatic or aromatic aldehydes and amides in the presence of 2 mol % of anhydrous zinc chloride. The synthesis successfully employed Lewis acid as catalyst.

Chloromethylation Research of LX-1180 Macroporous Adsorption Resin in Ultrasonic Environment

This work performed the chloromethylation study of LX1180 in an ultrasonic environment, and presented a novel method to realize high chloromethylation degree for high crosslinking MARs. During this process, Monochloromethyl ether and anhydrous zinc chloride was adopted as chloromethylation reagent and catalyst respectively, the influences of conditions on the chloromethylation degree were investigated and optimized systemically. The sample prepared under the optimization conditions possessed the chloromethylation degree of 2.87 mmol/g.