Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver

Statin treatment is a major prevention treatment for hypercholesterolemia and the management of patients with increased risk of cardiovascular disease (CVD) due to its protective effects. However, its long-term safety was questioned regarding its potential role in new-onset type 2 diabetes mellitus, and its effect on gene regulation in the liver is not yet fully understood. By reanalyzing the transcriptome of the livers of patients with obesity and hypercholesterolemia, this study shows a multiple module organization that is related to various clinical metabolic parameters and identified an expression hierarchical network involving cholesterol and fatty acid syntheses in the liver of statin-treated patients. The key genes of the network were validated by QPCR in the hepatocytes upon statin treatment. The upregulation of the key enzymes involving the synthesis of Acetyl-CoA and the induction of gentle global acetylation of pan-protein and histone H4 in hepatocytes were observed. The study provides an overall view of the statin effect on transcriptional and post-transcriptional regulation of genes in the liver.

Cooperative Control for Multi-Module Charging Systems of Ultracapacitors

Ultracapacitors have recently received great attention for energy storage due to their small pollution, high power density, and long lifetime. In many applications, ultracapacitors need to be charged with a high current, where a multi-module charging system is typically adopted. Although the classical decentralized control method can control the charging process of ultracapacitors, there exists a problem that the charging current may be imbalanced among charging modules. In this paper, a cooperative cascade charging method is proposed for the multi-module charging system to reduce the current imbalance among charging modules. First, the state-space averaging method and graph theory are used to model the multiple-module charging system. Second, an effective cooperative cascade control is proposed, where the outer voltage loop stabilizes the output voltage to the desired voltage and the inner current loop guarantees the current of each charger to follow the target current. The block diagram is used to establish the closed-loop model of the charging system. In order to evaluate the proposed charging method, a laboratory prototype was established. Compared with the classical decentralized method, this method can effectively suppress the current imbalance, which is proved by simulation and experimental results.