Therapy of coronavirus infection

Background: The computer apparatus for electro-acupuncture diagnostics and medicated testing "IMEDIS-EXPERT" made in Russia was used for the purposes of this work to detect SARS-CoV-2 (COVID-19) or to prove its absence, and to select homoeopathic preparations, nosodes, and their relevant doses. The methods of the system-nosological approach (SNA) were used for the therapy of patients, which included recording and appliance of relevant control signals (C.S.) of homoeopathic preparations, both native and informational (electronic) copies. Aims: 1. Develop an algorithm to select preparations from the group of nosodes and homoeopathy to prevent the development of SARS-CoV-2 (COVID-19); 2. Evaluate the possibility of preventing treatment and therapy of coronavirus infection employing an "electronic vaccine" produced employing coronavirus C.S. Methodology: The electronic preventing "immunization" was made for patients as the preventing treatment of COVID-19, which was an adaptation to coronavirus C.S. conducted in accordance with a special algorithm. The three-block scheme of SNA therapy was used for the therapy of ill patients, which was composed of three preparations, which were used sequentially: 1. Control signal of coronavirus targeted on a patient's CMH; 2. Cerebral response (C.R.) with a patient's cumulative impact of: C.S. of coronavirus and the sum of target organs (blood-forming system, lymphatic systems, lungs, bronchus, gastrointestinal system) and test-indicators of immune regulation targeted on the second CMH marker amplification; 3. Drainages in the form of homeopathic preparations were used (after the impact of two previous preparations), which were: Arsenicum, Arsenicum iod, Carbo vegetabilis, Spongia, Drosera, Naya, Rhus Toxicodendron, and Ferrum met. The preparations were selected to compensate the third impact of CMH. Results: At present, 175 people have asked for help due to COVID-19, an electronic preventing vaccine ("immunization") made for 112 people on the SNA algorithm. According to the diagnostic testing results made for 63 ill patients and who asked for treatment: 47 people tested coronavirus infection, 16 people tested ARVI, and 12 people tested pneumonia caused by a virus. The coincidence of VRT tests (vegetative resonance tests) and PCR was found ranged from 68 to 75%. 4 people got ill by coronavirus among those who got preventing immunization (112 people) by "the electronic sensibilization method" (that was proved by VRT and PCR tests). The illness had the light form among 2 of them, and two people had moderate severity of illness without hospital admission. Conclusion: An algorithm is developed, which allows to select C.S. of therapeutic nosodes and homoeopathic preparations to prevent the development of SARS-CoV-2. The efficiency of applying the electronic immunization method according to the algorithms of SNA using coronavirus C.S. is 95%.

Использование современных препаратов в комплексном лечении и профилактика воспалительных заболеваний пародонта у детей

In the study process participated schoolсhildren with diagnosis of chronic catarrhal gingivitis (HKG) and chronic periodontitis light form (HPLC). In total 103 patient, 67 patient with chronic catarrhal gingivitis and 36 patient with chro nic periodontitis light form. The laboratory results showed that in the process of conducting treatment and preventive measures during the use of the drug Loroben the functional activity of the local immune factors were significantly restored. If we pay attention to indicators after professional hygiene and local application of a solution of digluconate of chlorhexidine, after treatment with Loroben values significantly increased . Solution of Loroben improves trophic of the periodontal tissues, promotes the elimination of bleeding gums and inflammation, and these promotes positive treatment outcome.

Creating Red Light-Controlled Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity

Protein dimerization systems that can be controlled by red light with increased tissue penetration depth are a highly needed optogenetic tool for clinical applications such as cell and gene therapies. However, existing red light-induced dimerization systems are all based on phytochrome photoreceptors and naturally occurring binding partners with complex structures and suboptimal in vivo performance, limiting mammalian applications. Here, we introduce an efficient, generalizable method (COMBINES-LID) for creating highly specific light-induced dimerization systems. Proof-of-principle was provided by creating nanobody-based, red light-induced dimerization (nanoReD) systems comprising a truncated bacterial phytochrome sensory module using a mammalian endogenous chromophore, biliverdin, and light-form specific nanobodies. Selected nanoReD systems were biochemically characterized and exhibited low dark activity and high induction specificity for in vivo activation of gene expression. Overall, COMBINES-LID opens new opportunities for creating genetically encoded actuators for the optical manipulation of biological processes.

SYNTOPIC ELYMNIAS AGONDAS ARUANA FEMALE FORMS MIMIC DIFFERENT TAENARIS MODEL SPECIES (PAPILIONOIDEA: NYMPHALIDAE: SATYRINAE) ON ARU, INDONESIA

Wing patterns of female Elymnias agondas (Boisduval, 1832) butterflies are highly variable, presumably to mimic different Taenaris species throughout New Guinea and surrounding islands. Labels on most E. agondas museum specimens lack precise locality information, complicating efforts to match E. agondas female wing patterns with presumed Taenaris model species. This paucity of data also makes it impossible to determine where different forms occur and whether they are strictly allopatric. During fieldwork on the Aru Archipelago, we found two distinct forms of E. agondas females occurring syntopically. The “light form” resembles T. catops, while the “dark form” seems to mimic T. myops and T. artemis. We discuss the significance of this finding and illustrate species in the Taenaris mimicry ring encountered on Aru.

FUNCTIONAL RECOVERY OF VOICE FUNCTION IN PATIENTS WITH LARYNGEAL DYSFUNCTION: OBSERVATIONAL STUDY

Introduction: Functional recovery of voice function in patients with laryngeal dysfunction is a slow and lengthy process that is associated with changes in social and economic living conditions. The serious functional damage can also lead to disorders in swallowing and respiratory function. It is believed that paresis passes into definitive if continues for more than 10-12 months due to irreversible changes in the tissues. According to literature data, spontaneous recovery in unilateral vocal cord paralysis is observed in 40% of cases. Low frequency currents with adjustable parameters are frequently used in the practice of electro diagnostics and electrical stimulation in damage of the neuromuscular system and in particular in laryngeal paresis and paralysis. In recent decades, an increase in the number of patients suffering from diseases associated with laryngeal dysfunction was noted by many authors. Interruption of nervous pulsation to laryngeal structures leads to sensory and motor disorders and development of subsequent paralysis of the muscles. Treatment depends on the cause, the severity of the symptoms and time of onset of the disease. It includes non-operative and operative treatment. Non-operative treatment is with good results and should precede surgery. Purpose: The purpose of this study is to objectify the therapeutic options of neuromuscular elektro-phonatory stimulation /NMEPS/ in patients with laryngeal dysfunction. Materials and methods: The study included 21 patients with unilateral dysfunction of n. laryngeus recurens after surgery of the thyroid gland. Patients with complete denervation were excluded from the study. Procedures are preceded by electro-diagnostic in direct laryngoscopy to establish the extent of damage of the nerve and to determin the coefficient of accommodation (ACC) and variable parameters for stimulus currents. Therapeutic session is implemented in two stages: (1) 'heating' with galvanic current, and (2) real NMEPS selective stimulation of the damaged muscle, leaving untreated antagonists or neighboring healthy muscles, accompanied by active and targeted implementation of Förster phonatoric exercises, coughing and breathing. Treatment is organized in courses for 10 days, 20 procedures per course. Results: The results before and after completion of therapeutic course by assessing changes in the coefficient of accommodation(ACC), voice quality, degree of hoarseness, coughing efficiency, presence of dysphagia are reported. After statistical processing of the obtained results a statistical dependence in relation to dysphonia before and after NMEPS therapy was established (p=0.0001), which is expressed in improvement of medium to mild dysphonia. In relation to dysphagia we found improvement from average-heavy to light form of dysphagia and absence of any symptoms of it after treatment, but there are patients with no change observed (44.4%) and statistical dependence (p=0.005) Patients with dysfunction regarding the effectiveness when coughing, before treatment they were: 16.7%, with severe dysfunction, 50.0% with moderate to severe and 33.3% with light. After NMEPS therapy improvement in the condition of patients with moderate-heavy to light form was observed. The non-parametric analysis proved statistical dependence (Z=3.58 ;p=0.0001). All patients were asked to assess the quality of their voice according to the Linkert five-point rating scale. In the beginning of the therapy 44.4% of the patients ranked their voice quality as poor, 50.0% as moderate and 5.6% as good. After treatment improvement in self-assessment of voice quality from moderate to very good and statistical dependence (p=0.0001) was observed. Conclusion: The results of the observational study prove that NMEPS therapy is effective for functional recovery in complex treatment of laryngeal dysfunction. Because of the small number of patients included in the study for better objectifying of the effects of the neuro muscular elektro-phonatory stimulation, the studies should continue.

Jyotirliṅga Tradition: Pilgrimage, Myth, and Art

A jyotirliṅga (“liṅga of light”) is one of the foremost ways that the deity Śiva has been represented in mythology and art. It is an important sub-type of the deity’s liṅga (mark, sign, phallus). A well-known example is the network of twelve pilgrimage sites spread across the Indian subcontinent. In their related mythology each site accounts for a theophany of Śiva in light form, descending from heaven and remaining at the pilgrimage center in the form of a liṅga. The development and growth of this pilgrimage network within the sacred topographies of Śiva is relatively understudied, but new scholarship in the Purāṇas and Śaivadharma traditions as well as the archaeology of individual sites connected to these texts are helping to alleviate this paucity. Beginning in roughly the 10th century, fire and light imagery is integrated into different forms of Śaiva ritual, myth, and art as part of a strategy to popularize Śaivism. While the theme ‘God is light’ (numen lumen) is ubiquitous across religious traditions, its integration within Śaivism occurred for particular historical, theological, and sectarian reasons. One is the development of mythic themes related to light and fire as seen through the liṅgodbhavamūrti (form arising from the liṅga) and Devadāruvana (Pine Forest) mythemes. The earliest example of the liṅgodbhavamūrti likely dates to the 7th century, while the Devadāruvana can be traced to the Mahābhārata (Book 10.17). A second reason for the development of fire and light imagery is seen through the Śaiva encounter with Gupta period images of the Buddha’s fiery form and Buddhist commentarial literature. In addition, Śaiva encounters with universalizing tendencies within Islam, especially seen through the rise of Viśveśvara (Lord of the Universe) in Vārāṇasī, informed this developing tradition. Scholarship and sources about jyotirliṅgas can be structured around three major categories: the network of twelve jyotirliṅgas, the liṅgodbhavamūrti, and the Devadāruvana. Each of these categories has a diverse body of textual, inscriptional, art historical, and archaeological sources.