Dynamic Coercivity of Tempered Ferritic Steel Subjected to Creep-Fatigue for Nondestructive Evaluation by Reversible Permeability

This study aims to characterize nondestructively the creep-fatigue damage of tempered ferritic steel by dynamic coercivity measured by reversible permeability. The creep-fatigue test was achieved under load control with a hold time of 60 s and 600 s. The dynamic coercivity based on the reversible magnetic permeability profiles was successfully obtained on top of the test specimen. Based on these results, we attempted to evaluate the creep-fatigue of tempered ferritic steel with the support of microstructural evaluation such as dislocations and precipitates. The dynamic coercivity decreases with fatigue life fraction and closely related to the number of Cr23C6 precipitates with N0.8 and the dislocation density with ρ0.4 In addition, Vickers’s hardness continuously decreased up to the failure deducing the softening of mechanical strength. In conclusion, it can nondestructively characterize the influence of the precipitates and dislocation density on the dynamic coercivity of ferritic steel during creep-fatigue.

Transient and sustained increases in glomerular permeability following ANP infusion in rats

The present study was performed to investigate the effects of systemic atrial natriuretic peptide (ANP) infusion on the glomerular permeability to macromolecules in rats. In anesthetized Wistar rats (250–280 g), the left urether was cannulated for urine collection while simultaneously blood access was achieved. Rats were continuously infused intravenously with ANP [30 ng·kg−1·min−1 (Lo-ANP; n = 8) or 800 ng·kg−1·min−1 (Hi-ANP; n = 10)] or 0.9% NaCl (SHAM; n = 16), respectively, and with polydisperse FITC-Ficoll-70/400 (molecular radius 13–90 Å) and 51Cr-EDTA for 2 h. Plasma and urine samples were taken at 5, 15, 30, 60, and 120 min of ANP infusion and analyzed by high-performance size-exclusion chromatography (HPLC) for determination of glomerular sieving coefficients (θ) for Ficoll. GFR was also assessed (51Cr-EDTA). In Hi-ANP, there was a rapid (within 5 min), but bimodal, increase in glomerular permeability. θ to high-molecular-weight Ficoll thus reached a maximum at 15 min, after which θ returned to near control at 30 min, to again increase moderately at 60 and 120 min. In Lo-ANP, there was also a rapid, reversible increase in glomerular θ, returning to near control at 30 min, followed by just a tendency of a sustained increase in permeability, but with a significant increase in “large-pore” radius. In conclusion, in Hi-ANP there was a rapid increase in glomerular permeability, with an early, partly reversible permeability peak, followed by a (moderate) sustained increase in permeability. In Lo-ANP animals, only the initial permeability peak was evident. In both Lo-ANP and Hi-ANP, the glomerular sieving pattern observed was found to mainly reflect an increase in the number and radius of large pores in the glomerular filter.