ERP Indicators of Self-Pain and Other Pain Reductions due to Placebo Analgesia Responding: The Moderating Role of the Fight-Flight-Freeze System

This study evaluates the modulation of phasic pain and empathy for pain induced by placebo analgesia during pain and empathy for pain tasks. Because pain can be conceptualized as a dangerous stimulus that generates avoidance, we evaluated how approach and avoidance personality traits modulate pain and empathy for pain responses. We induced placebo analgesia to test whether this also reduces self-pain and other pain. Amplitude measures of the N1, P2, and P3 ERPs components, elicited by electric stimulations, were obtained during a painful control, as well as during a placebo treatment expected to induce placebo analgesia. The placebo treatment produced a reduction in pain and unpleasantness perceived, whereas we observed a decrease in the empathy unpleasantness alone during the empathy pain condition. The moderator effects of the fight-flight-freeze system (FFFS) in the relationships linking P2 and P3 amplitude changes with pain reduction were both significant among low to moderate FFFS values. These observations are consistent with the idea that lower FFFS (active avoidance) scores can predict placebo-induced pain reduction. Finally, in line with the revised Reinforcement Sensitivity Theory (r-RST), we can assume that phasic pain is an aversive stimulus activating the active-avoidance behavior to bring the system back to homeostasis.

A Comparison of Reinforcement Sensitivity Theory Measures: Unique Associations With Social Interaction Anxiety and Social Observation Anxiety

Evidence suggests that the behavior inhibition system (BIS) and fight-flight-freeze system play a role in the individual differences seen in social anxiety disorder; however, findings concerning the role of the behavior approach system (BAS) have been mixed. To date, the role of revised reinforcement sensitivity theory (RST) subsystems underlying social anxiety has been measured with scales designed for the original RST. This study examined how the BIS, BAS, and fight, flight, freeze components of the fight-flight-freeze system uniquely relate to social interaction anxiety and social observation anxiety using both a measure specifically designed for the revised RST and a commonly used original RST measure. Comparison of regression analyses with the Jackson-5 and the commonly used BIS/BAS Scales revealed important differences in the relationships between RST subsystems and social anxiety depending on how RST was assessed. Limitations and future directions for revised RST measurement are discussed.

Discussion on ‘Automatic and Controlled Processes in Behavioural Control: Implications for Personality Psychology’ by Corr

This comment critiques Corr's (2010) characterization of the personality traits associated with the elements of Gray's conceptual nervous system: The behavioural inhibition system (BIS), the behavioural approach system (BAS) and the fight–flight–freeze system (FFFS). Most attention is paid to the FFFS because least is known about its manifestation in personality. Additionally, I suggest that Corr's framework for understanding automatic and controlled processing is useful for developing theories of the biological systems underlying traits that are not directly related to BIS, BAS and FFFS. Copyright © 2010 John Wiley & Sons, Ltd.

Differentiating defensive and predatory aggression: Neuropsychological systems and personality in sex differences

We draw a distinction between defensive and predatory forms of aggression, and how these forms relate to basic neuropsychological systems, especially the Fight-Flight-Freeze-System (FFFS; putatively related to defensive aggression), and the Behavioural Approach System (BAS; putatively related to predatory aggression). These systems may help further to account for proximal brain processes and personality influences in the context of sex differences.