benzophenanthridine alkaloid
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2021 ◽  
Vol 18 (9/10) ◽  
pp. 823
Author(s):  
S.V. Lutsenko ◽  
S.N. Orekhov ◽  
N.E. Sedyakina ◽  
L.I. Salitrinnik ◽  
T.I. Gromovykh ◽  
...  

2020 ◽  
Vol 8 ◽  
Author(s):  
Marzuq A. Ungogo ◽  
Godwin U. Ebiloma ◽  
Nahandoo Ichoron ◽  
John O. Igoli ◽  
Harry P. de Koning ◽  
...  

The West African country Nigeria features highly diverse vegetation and climatic conditions that range from rain forest bordering the Atlantic Ocean in the South to the Desert (Sahara) at the Northern extreme. Based on data from the World Conservation Monitoring Center of the United Nations Environmental Protection, Nigeria, with ~5,000 documented vascular plants, ranks amongst the top 50 countries in terms of biodiversity. Such a rich biodiversity implies that the country is rich in diverse secondary metabolites—natural products/unique chemicals produced by the plant kingdom to confer selective advantages to them. Like many tropical countries, Nigeria is also endemic to numerous infectious diseases particularly those caused by parasitic pathogens. These phytochemicals have been exploited for the treatment of diseases and as a result, a new branch of chemistry, natural product chemistry, has evolved, to try to reproduce and improve the therapeutic qualities of particular phytochemicals. In this review, we have compiled a compendium of natural products, isolated from Nigerian flora, that have been reported to be effective against certain protozoan parasites with the aim that it will stimulate interests for further investigations, and give impetus to the development of the natural products into registered drugs. In total 93 structurally characterized natural compounds have been identified with various levels of anti-parasite activity mainly from Nigerian plants. The synthesis protocol and molecular target for some of these natural anti-parasite agents have been established. For instance, the anti-plasmodial compound fagaronine (7), a benzophenanthridine alkaloid from Fagara zanthoxyloides has been successfully synthesized in the laboratory, and the anti-trypanosomal compound azaanthraquinone (55) elicits its effect by inhibiting mitochondrial electron transfer in trypanosomes. This review also discusses the barriers to developing approved drugs from phytochemicals, and the steps that should be taken in order to accelerate the development of new antiparasitics from the highlighted compounds.


Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1261
Author(s):  
Andrea Balažová ◽  
Júlia Urdová ◽  
Vladimír Forman ◽  
Pavel Mučaji

Macarpine is a minor benzophenanthridine alkaloid with interesting biological activities, which is produced in only a few species of the Papaveraceae family, including Eschscholzia californica. Our present study was focused on the enhancement of macarpine production in E. californica suspension cultures using three elicitation models: salicylic acid (SA) (4; 6; 8 mg/L) elicitation, and simultaneous or sequential combinations of SA and L-tyrosine (1 mmol/L). Sanguinarine production was assessed along with macarpine formation in elicited suspension cultures. Alkaloid production was evaluated after 24, 48 and 72 h of elicitation. Among the tested elicitation models, the SA (4 mg/L), supported by L-tyrosine, stimulated sanguinarine and macarpine production the most efficiently. While sequential treatment led to a peak accumulation of sanguinarine at 24 h and macarpine at 48 h, simultaneous treatment resulted in maximum sanguinarine accumulation at 48 h and macarpine at 72 h. The effect of SA elicitation and precursor supplementation was evaluated also based on the gene expression of 4′-OMT, CYP719A2, and CYP719A3. The gene expression of investigated enzymes was increased at all used elicitation models and their changes correlated with sanguinarine but not macarpine accumulation.


2018 ◽  
Vol 15 (4/5) ◽  
pp. 280
Author(s):  
N.B. Feldman ◽  
V.N. Kuryakov ◽  
N.E. Sedyakina ◽  
T.I. Gromovykh ◽  
S.V. Lutsenko

Phytomedicine ◽  
2017 ◽  
Vol 34 ◽  
pp. 143-153 ◽  
Author(s):  
Sehamuddin Galadari ◽  
Anees Rahman ◽  
Siraj Pallichankandy ◽  
Faisal Thayyullathil

2017 ◽  
Vol 12 (3) ◽  
pp. 1934578X1701200
Author(s):  
Jabar B.P.A.A. Agbo ◽  
James D.S. Mpetga ◽  
Raphael Bikanga ◽  
Roland T. Tchuenguem ◽  
Rolande B.N. Tsafack ◽  
...  

Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL ( Candida albicans) and dihydrochelerythrine (2) [MIC = 32 ( C. albicans and C. parapsilosis), and 128 μg/mL ( C. krusei)] had moderate to weak antifungal activity.


Fitoterapia ◽  
2016 ◽  
Vol 109 ◽  
pp. 196-200 ◽  
Author(s):  
Helle Wangensteen ◽  
Giang Thanh Thi Ho ◽  
Margey Tadesse ◽  
Christopher O. Miles ◽  
Nastaran Moussavi ◽  
...  

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