hair cell innervation
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eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Thomas M Coate ◽  
Nathalie A Spita ◽  
Kaidi D Zhang ◽  
Kevin T Isgrig ◽  
Matthew W Kelley

Auditory function is dependent on the formation of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs). In particular, type I SGNs must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs). The factors that mediate these patterning events are largely unknown. Using sparse-labeling and time-lapse imaging, we visualized for the first time the behaviors of developing SGNs including active retraction of processes from OHCs, suggesting that some type I SGNs contact OHCs before forming synapses with IHCs. In addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs. These results suggest a model in which cochlear innervation patterns by type I SGNs are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes processes from extending beyond the IHC region.


1988 ◽  
Vol 105 (5-6) ◽  
pp. 398-402 ◽  
Author(s):  
Mireille Lavigne-Rebillard ◽  
Rémy Pujol

Science ◽  
1982 ◽  
Vol 217 (4555) ◽  
pp. 175-177 ◽  
Author(s):  
N. Kiang ◽  
J. Rho ◽  
C. Northrop ◽  
M. Liberman ◽  
D. Ryugo

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