in vitro intestinal permeability
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2019 ◽  
Vol 99 (7) ◽  
pp. 3481-3489 ◽  
Author(s):  
Gabriela Vazquez‐Olivo ◽  
Marilena Antunes‐Ricardo ◽  
Janet A Gutiérrez‐Uribe ◽  
Tomás Osuna‐Enciso ◽  
Josefina León‐Félix ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sajal Kumar Jha ◽  
Roopa Karki ◽  
Venkatesh Dinnekere Puttegowda ◽  
D. Harinarayana

The absolute bioavailability of famotidine after oral administration is about 40–45% and absorbance only in the initial part of small intestine may be due to low intestinal permeability. Hence, an olive oil based microemulsion formulation with Tween-80 as surfactant and PEG-400 as cosurfactant was developed by using water titration method with the aim of enhancing the intestinal permeability as well as oral bioavailability. In vitro drug permeation in intestine after 8 h for all formulations varied from 30.42% to 78.39% and most of the formulations showed enhanced permeation compared to pure drug (48.92%). Famotidine microemulsion exhibited the higher absorption and Cmax⁡ achieved from the optimized famotidine formulation (456.20 ng·h/ml) was higher than the standard (126.80 ng·h/mL). It was found that AUC0–24 h obtained from the optimized famotidine test formulation (3023.5 ng·h/mL) was significantly higher than the standard famotidine (1663.3 ng·h/mL). F-1 demonstrated a longer (6 h) Tmax⁡ compared with standard drug (2 h) and sustained the release of drug over 24 h. The bioavailability of F-1 formulation was about 1.8-fold higher than that of standard drug. This enhanced bioavailability of famotidine loaded in microemulsion system might be due to increased intestinal permeability.


PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109939 ◽  
Author(s):  
Sofie Trier ◽  
Lars Linderoth ◽  
Simon Bjerregaard ◽  
Thomas Lars Andresen ◽  
Ulrik Lytt Rahbek

2011 ◽  
Vol 13 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Jadel M. Kratz ◽  
Marina R. Teixeira ◽  
Karine Ferronato ◽  
Helder F. Teixeira ◽  
Letícia S. Koester ◽  
...  

1995 ◽  
Vol 108 (3) ◽  
pp. 687-696 ◽  
Author(s):  
Pieter B. Bijlsma ◽  
Roger A. Peeters ◽  
Jack A. Groot ◽  
Pieter R. Dekker ◽  
Jan A.J.M. Taminiau ◽  
...  

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