SYNTHESIS, CHARACTERIZATION OF SOME SUBSTITUTED BIPHENYL-2- AMINOTHIAZOL DERIVATIVES

The synthesis explored to serve novel functional group extended Anti-microbial bio-active molecules of substituted Aminothiazoles. It reveals from overall available up to date literature feedback of Aminothiazoles, it is difcult to synthesis of substituted biphenyl-2-aminothiazoles from Suzuki coupling reaction of 5-(4-bromophenyl) thiazol-2-amine with substituted Boronic acids in presence of Palladium (II) acetate catalyst and in 5% aqueous Isopropyl alcohol used as a solvent. This is a shortest pathway to synthesis of biphenyl derivatives of Aminothaizoles by Suzuki coupling method.

Intermolecular Interaction of Glycyrrhizin with Cholesterol

The 1:1 molecular complex of licorice triterpene glycoside glycyrrhizic acid (in the form of monoammonium salt) with cholesterol was obtained in 80% aqueous isopropyl alcohol for the first time. The complexation was studied by 13C NMR, UV, and ATR IR-Fourier spectroscopy. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex.

Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

The 1:1 molecular complex of ivy triterpene glycoside hederasaponin C (HedC) with cholesterol (Chol) was obtained in aqueous isopropyl alcohol. The stability constant of (3.3 ± 0.7)∙106 (mol/L)–1 was calculated for the complex. The complexation was studied by UV- and ATR IR-Fourier spectroscopy, and method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex.

INVESTIGATION IMIDAZOLINE DERIVATIVES OBTAINED FROM SYNTHETIC PETROLEUM ACIDS AS CORROSION INHIBITOR

Imidazoline derivatives have been synthesized based on the synthetic petroleum acids (SPA) and diethylentriamine. Complexes were prepared from these compounds and HCl in ratio 1:1, 1:2, 1:3. 20% solution of the complexes were prepared in aqueous isopropyl alcohol. The kinetic effect of steel corrosion in 1% NaCl solution saturated with CO2 were studied ACM Gill AC potentiometer. It was found that, the imidazoline derivatives complexes based on the SPA and DETA with HCl in molar ratio 1:1 of 25 ppm concentration protection from corrosion is 83,5%, 100 ppm concentration – 97,1%; the proportion of 1:2 complex of 25 ppm – 82,8%, 100 ppm concentration – 97,3%, but in the case of the 1:3 complex shows the best result - 94 and 98,8%.