NITROSYL FERREDOXINES MIMETICS AS PHOSPHODIESTERASE INHIBITORS: SYNTHESIS, STRUCTURE AND ACTIVITY IN VITRO

The paper presents and discusses experimental data on the synthesis, study of the structure and properties in the solid phase and in solutions of new low-molecular-weight iron dinitrosyl complexes with N,S-ligands of the 1,2,4 -1-H-triazole N,S-ligands of the“g = 2.03” family, nitric oxide (NO) donors, and effective inhibitors of cGMP phosphodiesterases.

ДИНИТРОЗИЛЬНЫЕ КОМПЛЕКСЫ ЖЕЛЕЗА C ТИОЛСОДЕРЖАЩИМИ ЛИГАНДАМИ ПРЕДСТАВЛЕНЫ В ЖИВЫХ ОРГАНИЗМАХ В ОСНОВНОМ ИХ БИЯДЕРНОЙ ФОРМОЙ

The number of mononitrosyl iron complexes with diethyldithiocarbamate, formed in the liver of mice in vivo and in vitro after intraperitoneal injection of binuclear dinitrosyl iron complexes with N-acetyl-L-cysteine or glutathione, S-nitrosoglutathione, sodium nitrite or the vasodilating drug Isoket® was assessed by electron paramagnetic resonance (EPR). The number of the said complexes, in contrast to the complexes, formed after nitrite or Isoket administration, the level of which sharply increased after treatment of liver preparations with a strong reducing agent - dithionite, did not change in the presence of dithionite. It was concluded that, in the first case, EPR-detectable mononitrosyl iron complexes with diethyldithiocarbamate in the absence and presence of dithionite appeared as a result of the reaction of NO formed from nitrite with Fe2+-dieth- yldithiocarbamate and Fe3+-diethyldithiocarbamate complexes, respectively. In the second case, mononitrosyl iron complexes with diethyldithiocarbamate appeared as a result of the transition of iron-mononitosyl fragments from ready-made iron-dinitrosyl groups of binuclear dinitrosyl complexes, which is three to four times higher than the content of the mononuclear form of these complexes in the tissue...

Structures and Properties of Dinitrosyl Iron and Cobalt Complexes Ligated by Bis(3,5-diisopropyl-1-pyrazolyl)methane

Two dinitrosyl iron and cobalt complexes [Fe(NO)2(L1”)](BF4) and [Co(NO)2(L1”)](BF4) are synthesized and characterized, supported by a less hindered bidentate nitrogen ligand bis(3,5-diisopropyl-1-pyrazolyl)methane (denoted as L1”), are surprisingly stable under argon atmosphere. X-ray structural analysis shows a distorted tetrahedral geometry. Spectroscopic and structural parameters of the dinitrosyl iron and cobalt complexes are consistent with the previous reported {Fe(NO)2}9 and {Co(NO)2}10. Two N–O and M–N(O) stretching frequencies and their magnetic properties are also consistent with the above electronic structural assignments. We explored the dioxygen reactivities of the obtained dinitrosyl complexes. Moreover, the related [FeCl2(L1”)], [Co(NO3)2(L1”)], and [Co(NO2)2(L1”)] complexes are also characterized in detail.