Hybrid nanotechnology and peptide nucleic acid could improve the effectiveness of gene therapy by increasing its cell permeability

The utilization of nanoparticles and carbon nanotubes in PNA-based technologies has opened the way for the application of nanotechnology in oligonucleotide compilation. It is possible that further study may offer insight into how to improve the effectiveness of oligonucleotides by increasing their cell permeability. Because PNA accumulates within the cell when it is transported by a lipid-based carrier, it has insufficient cytosolic dispersion, which greatly limits its medicinal potential. This finding suggests that nanoparticles and nanostructures that are similar in appearance to carbon nanotubes can be employed to efficiently disseminate PNA. Innovative ways of intracellular delivery of PNA, such as the use of viruses and nutrients, will require significant and in-depth exploration before they can reach their full potential.

Coarse-grained nucleic acid–protein model for hybrid nanotechnology

A coarse-grained model for analysis and design of hybrid DNA-protein nanoscale structures.