The oxidative reactivity of three manganese (III) porphyrin complexes with hydrogen peroxide and nitrite towards catalytic nitration of protein tyrosine

Understanding the toxicological properties of MnIII-porphyrins (MnTPPS, MnTMPyP or MnTBAP) can provide important biochemical rationales in developing them as the therapeutic drugs against protein tyrosine nitration induced inflammation diseases. Here, we present a comprehensive understanding of the pH-dependent redox behaviors of these MnIII-porphyrins and their structural effects on catalyzing bovine serum albumin (BSA) nitration in the presence of H2O2 and NO2−. It was found that both MnTPPS and MnTBAP stand out in catalyzing BSA nitration at physiologically close condition (pH 8), yet they are less effective at pH 6 and 10. MnTMPyP was shown no ability to catalyze BSA nitration under all tested pHs (pH 6, 8 and 10). The kinetics and active intermediate determination through electrochemistry method revealed that both the pH-dependent redox behavior of the central metal cation and the antioxidant capability of porphin derivative contribute to the catalytic activities of three MnIII-porphyrins in BSA nitration in the presence of H2O2/NO2−. These comprehensive studies on the oxidative reactivity of MnIII-porphyrins towards BSA nitration may provide new clues for searching the manganese based therapeutic drugs against the inflammation related diseases.

Fe- and Mn-modified SO42-/ZrO2 conjoined O2-Ac2O as composite catalytic system for highly selective nitration of 1-nitronaphthalene with NO2 to valuable 1,5-dinitronaphthalene

In present study, a mild and efficient method for highly selective preparation of 1,5-dinitronaphthalene from the catalytic nitration of 1-nitronaphthalene with NO2 promoted by O2-Ac2O over Fe- and Mn-modified SO42-/ZrO2...

Practical catalytic nitration directly with commercial nitric acid for the preparation of aliphatic nitroesters

To pursue a sustainable and efficient approach for aliphatic nitroester preparation from alcohol, europium-triflate-catalyzed nitration, which involves the direct use of commercial nitric acid, has been successfully developed.

H3PW12O40 synergized with MCM-41 for the catalytic nitration of benzene with NO2 to nitrobenzene

In this work, NO2 as a nitration agent and the supported HPW/MCM-41 as a synergistic catalyst to replace traditional nitric acid and sulfuric acids were employed to catalyze benzene nitration to nitrobenzene.