copolymer microgels
Recently Published Documents


TOTAL DOCUMENTS

33
(FIVE YEARS 2)

H-INDEX

18
(FIVE YEARS 0)

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3181
Author(s):  
Maxim Dirksen ◽  
Timo Alexander Kinder ◽  
Timo Brändel ◽  
Thomas Hellweg

CBD is a promising candidate for treatment of many diseases and plays a major role in the growing trend to produce high-end drugs from natural, renewable resources. In the present work, we demonstrate a way to incorporate the anti-inflammatory drug CBD into smart microgel particles. The copolymer microgels that we chose as carrier systems exhibit a volume phase transition temperature of 39 ∘C, which is just above normal body temperature and makes them ideal candidates for hyperthermia treatment. While a simple loading route of CBD was not successful due to the enormous hydrophobicity of CBD, an alternative route was developed by immersing the microgels in ethanol. Despite the expected loss of thermoresponsive behaviour of the microgel matrix due to the solvent exchange, a temperature-dependent release of CBD was detected by the material, creating an interesting question of interactions between CBD and the microgel particles in ethanol. Furthermore, the method developed for loading of the microgel particles with CBD in ethanol was further improved by a subsequent transfer of the loaded particles into water, which proves to be an even more promising approach due to the successful temperature-dependent release of the drug above the collapse temperature of the microgels.


Soft Matter ◽  
2021 ◽  
Author(s):  
Johannes Bookhold ◽  
Lars Wiehemeier ◽  
Maxim Dirksen ◽  
Sebastian Knust ◽  
Dario Anselmetti ◽  
...  

Poly(N-isopropylacrylamide) (pNIPAM) based copolymer microgels were used to create free-standing, transferable, thermoresponsive membranes. The microgels were synthesized by copolymerization of NIPAM with N-benzylhydrylacrylamide (NBHAM). Monolayers of these colloidal gels were...


2020 ◽  
Vol 11 (2) ◽  
pp. 315-325 ◽  
Author(s):  
Sabine Schneider ◽  
Falco Jung ◽  
Olga Mergel ◽  
Janik Lammertz ◽  
Anne C. Nickel ◽  
...  

Modelling and synthesis go hand in hand to efficiently engineer copolymer microgels with various architectures: core–shell structures (with ferrocene mainly in the core or in the shell) and also microgels with homogeneous comonomer distribution.


RSC Advances ◽  
2020 ◽  
Vol 10 (70) ◽  
pp. 42718-42732
Author(s):  
A. D. Drozdov ◽  
J. deClaville Christiansen

A model is developed for equilibrium swelling of thermo-responsive copolymer gels and is applied to predict the effect of molar fraction of comonomers on the volume phase transition temperature of macroscopic gels and microgels.


2019 ◽  
Vol 572 ◽  
pp. 480-488 ◽  
Author(s):  
Yusak Hartanto ◽  
Masoumeh Zargar ◽  
Xiaolin Cui ◽  
Bo Jin ◽  
Sheng Dai

Soft Matter ◽  
2019 ◽  
Vol 15 (28) ◽  
pp. 5673-5684 ◽  
Author(s):  
Lars Wiehemeier ◽  
Timo Brändel ◽  
Yvonne Hannappel ◽  
Tilman Kottke ◽  
Thomas Hellweg

Surfactant-assisted precipitation polymerization of N-isopropylacrylamide (NIPAM) and acrylic acid (AAc) is used to make thermo- and pH-responsive copolymer microgels. The type of surfactant is found to have an impact on the particle properties.


2018 ◽  
Vol 10 (24) ◽  
pp. 20869-20875 ◽  
Author(s):  
Mohammad Vatankhah-Varnosfaderani ◽  
Xiaobo Hu ◽  
Qiaoxi Li ◽  
Hossein Adelnia ◽  
Maria Ina ◽  
...  
Keyword(s):  

Polymer ◽  
2017 ◽  
Vol 125 ◽  
pp. 110-116 ◽  
Author(s):  
Timo Brändel ◽  
Lars Wiehemeier ◽  
Tilman Kottke ◽  
Thomas Hellweg

2016 ◽  
Vol 518 ◽  
pp. 273-281 ◽  
Author(s):  
Yusak Hartanto ◽  
Masoumeh Zargar ◽  
Xiaolin Cui ◽  
Yinghua Shen ◽  
Bo Jin ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document