ccnd1 g870a
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Medicine ◽  
2017 ◽  
Vol 96 (42) ◽  
pp. e8269 ◽  
Author(s):  
Mei Xie ◽  
Fen Zhao ◽  
Xiaoling Zou ◽  
Shuai Jin ◽  
Shaoquan Xiong

Oncotarget ◽  
2016 ◽  
Vol 7 (40) ◽  
pp. 66109-66118 ◽  
Author(s):  
Yafei Zhang ◽  
Xianling Zeng ◽  
Hongwei Lu ◽  
Hong Ji ◽  
Enfa Zhao ◽  
...  

2016 ◽  
Vol 5 (2) ◽  
pp. 157
Author(s):  
Samia Ebeid ◽  
Nadia Abd El Moneim ◽  
Taha Hewala ◽  
Moustafa Ramadan ◽  
Gehan Shehata ◽  
...  

Aim: To investigate the influence of the polymorphic variants of CCND1 (G870A) and p73 (G4C14- to- A4T14) on the susceptibility to breast cancer development, also, to figure out their diagnostic and prognostic roles.Subjects and Methods: Blood samples were obtained from breast cancer patients and controls. Genotyping of CCND1 and p73 genes were carried out by PCR-RFLP and PCR-CTPP; respectively.Results: In comparison with the control group, CCND1 (G870A) GA and AA genotypes frequencies were significantly higher in breast cancer patients (p=0.035 and p=0.002; respectively), whereas CCND1 (G870A) GG genotype frequency was significantly lower (p< 0.001). The CCND1 GA and AA genotypes significantly increased the risk for developing breast cancer compared with the GG genotype. The CCND1 (GA+AA) genotypes were significantly correlated with disease-free survival (DFS) of breast cancer patients. In comparison with the control group, p73 (G4C14/A4T14) GC/AT and AT/AT genotypes frequencies were significantly higher in breast cancer patients (p=0.013 and p=0.04; respectively), whereas p73 (G4C14/A4T14) GC/GC genotype frequency was significantly lower (p= 0.004).  Compared with the GC/GC genotype, the p73 GC/AT and AT/AT genotypes significantly increased the risk for developing breast cancer. Beside being significantly correlated with DFS, p73 [(GC/AT)+ (AT/AT)] genotypes were indirectly correlated with tumor size, tumor pathological grade, patient's clinical stage, number of axillary lymph node involvement and Her2/neu expression.Conclusion: The GA and AA genotypes of CCND1 (G870A) polymorphism and the GC/AT and AT/AT genotypes of p73 (G4C14- to- A4T14) polymorphism can be used as diagnostic markers in breast cancer patients. The presence of the CCND1 (G870A) GA and AA genotypes and the GC/AT and AT/AT genotypes of p73 (G4C14- to- A4T14) polymorphism can increase the susceptibility to breast cancer incidence. Both of CCND1 (G870A) and p73 (G4C14- to- A4T14) polymorphisms can be used for prognosis of breast cancer patients. 


2016 ◽  
Vol 4 (6) ◽  
pp. 1078-1084 ◽  
Author(s):  
XIAO-MING XU ◽  
XIAO-BING NI ◽  
GONG-LI YANG ◽  
ZHI-GUO LUO ◽  
YU-MING NIU ◽  
...  

2015 ◽  
Vol 10 (5) ◽  
pp. 3216-3222 ◽  
Author(s):  
MOHD NIZAM ZAHARY ◽  
ABDUL AZIZ AHMAD AIZAT ◽  
GURJEET KAUR ◽  
LEE YEONG YEH ◽  
MAYA MAZUWIN ◽  
...  

Tumor Biology ◽  
2015 ◽  
Vol 36 (9) ◽  
pp. 6891-6900 ◽  
Author(s):  
Zhenzhen Zeng ◽  
Jing Tu ◽  
Jin Cheng ◽  
Mingjie Yao ◽  
Yali Wu ◽  
...  

2014 ◽  
Vol 15 (16) ◽  
pp. 6923-6928 ◽  
Author(s):  
Ling-Yan Qin ◽  
Li-Gang Zhao ◽  
Xu Chen ◽  
Zheng Yang ◽  
Wu-Ning Mo

2014 ◽  
Vol 15 (8) ◽  
pp. 3607-3612 ◽  
Author(s):  
Ling-Yan Qin ◽  
Li-Gang Zhao ◽  
Xu Chen ◽  
Ping Li ◽  
Zheng Yang ◽  
...  

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