scholarly journals CCND1 G870A polymorphism and colorectal cancer risk: An updated meta-analysis

2016 ◽  
Vol 4 (6) ◽  
pp. 1078-1084 ◽  
Author(s):  
XIAO-MING XU ◽  
XIAO-BING NI ◽  
GONG-LI YANG ◽  
ZHI-GUO LUO ◽  
YU-MING NIU ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Ccnd1 G870a ◽  
Ccnd1 G870a Polymorphism

scholarly journals The association between CCND1 G870A polymorphism and colorectal cancer risk

Medicine ◽  
2017 ◽  
Vol 96 (42) ◽  
pp. e8269 ◽  
Author(s):  
Mei Xie ◽  
Fen Zhao ◽  
Xiaoling Zou ◽  
Shuai Jin ◽  
Shaoquan Xiong
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Colorectal Cancer Risk ◽  
Ccnd1 G870a ◽  
Ccnd1 G870a Polymorphism

scholarly journals Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 83306-83314 ◽  
Author(s):  
Zhanwei Zhao ◽  
Quanxin Feng ◽  
Zifang Yin ◽  
Jianbo Shuang ◽  
Bin Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Meat Consumption ◽  
Colorectal Cancer Risk ◽  
Processed Meat ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

scholarly journals Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

2019 ◽  
Author(s):  
Lin Zhang ◽  
Huachun Zou ◽  
Yang Zhao ◽  
Chunlei Hu ◽  
Adejare (Jay) Atanda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Asian Population ◽  
Colorectal Cancer Risk ◽  
Asian Countries ◽  
Case Control Studies ◽  
Vitamin D Levels

ABSTRACTObjectivesTo assess the association between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population.DesignThis is a systematic review and dose-response meta-analysis of observational studies that investigated the relationship between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population.Data SourcesRelevant studies were identified through a literature search in MEDLINE, EMBASE, and Web of Science from January 1980 to 31 January 2019. Eligibility criteria: original studies published in peer-reviewed journals investigating the association between blood circulating Vitamin D levels and the risk of colorectal cancer and/or adenoma in Asian countries.Data extraction and synthesisTwo authors independently extracted data and assessed the quality of included studies. Study-specific ORs were pooled using a random-effects model. A dose-response meta-analysis was performed with generalized least squares regression. We applied the Newcastle-Ottawa Scale quality assessment to evaluate the quality of the selected studies.ResultsThe eight included studies encompassed a total of 2,916 cases and 6,678 controls. The pooled ORs of colorectal cancer for the highest versus lowest categories of blood circulating Vitamin D levels was 0.75 [95% CI, 0.58-0.97] up to 36.5 ng/mL in the Asian population. There was heterogeneity among the studies (I2=53.9%, Pheterogeneity=0.034). The dose-response meta-analysis indicated a significant linear relationship (Pnon-linearity=0.11). An increment of 16 ng/mL in blood circulating Vitamin D level corresponded to an OR of 0.79 [95% CI, 0.64-0.97].ConclusionsThe results of this meta□analysis indicate that blood circulating Vitamin D level is associated with decreased risk of colorectal cancer in Asian countries. The dose-response meta-analysis shows that the strength of this association among the Asian population is similar to that among the Western population. Our study suggests that the Asian population should improve nutritional status and maintain a higher level of blood circulating Vitamin D.Strengths and limitations of this studyOur study seeks to extend previous work by including a number of new studies and by distinguishing the Asian population explicitly.The number of included studies is not sufficient to provide a robust estimate, so the results should be interpreted in the context of the limitations of the available data.Heterogeneous definitions of blood circulating Vitamin D categories were used across studies. The variability in definitions could limit comparability between studies.Our study included seven case-control studies; the study design implies that the measurement of blood circulating Vitamin D is measured in individuals already diagnosed with colorectal cancer. Results from case-control studies need to be interpreted cautiously because of the potential for reverse causation.Time of blood sampling in relation to outcome ascertainment also varied among studies. Such cross-sectional measurements may not accurately reflect an individual’s Vitamin D status across time.

XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis

Tumor Biology ◽  
2015 ◽  
Vol 36 (2) ◽  
pp. 461-466 ◽  
Author(s):  
Chang-Jiang Qin ◽  
Kai-Wu Xu ◽  
Zhi-Hui Chen ◽  
Er-Tao Zhai ◽  
Yu-Long He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Colorectal Cancer Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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