Preparation of imatinib base loaded human serum albumin for application in the treatment of glioblastoma

IMTb loaded HSA nanoparticles were prepared using a desolvation method at different pH and the encapsulation efficiency and drug loading capacity were tested.

Synthesis and Bioevaluation of Novel Imatinib Base Derivatives via 1,1′-Carbonyldiimidazole Catalyst

A series of eleven compounds were synthesized from 6-methyl-N′-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine with various substituted carboxylic acid under solvent-free conditions using 1,1′-carbonyldiimidazole (CDI) as a catalyst. The yields of compounds are more than 72%. All the compounds were characterized by physical, spectroscopic, and elemental analysis. Compound8bexhibited good inhibition towards antimicrobial activity compared to the other compounds.